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Date publication
janvier 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ZUBER Guy
Tous les auteurs :
Hallouard F, Anton N, Zuber G, Choquet P, Li X, Arntz Y, Aubertin G, Constantinesco A, Vandamme TF
Résumé
The context of the this research is the development of nanoparticulate systems exhibiting long circulation times in the blood pool, loaded with X-ray contrasting compounds, to be used as blood pool contrast agents in computed tomography. This study presents an original, new and simple formulation of radiopaque nano-emulsions composed of iodinated oil, formed by a spontaneous emulsification method. As a result, extremely monodisperse, iodinated nano-droplets were generated, ranging in size from 20 to 190 nm, presenting an iodine concentration of around 85 mg I/mL, and coated with a polyethylene glycol shell which ensured their stealth properties against the immune system in the blood stream. In vivo assays demonstrated a significant contrast effect, along with a long residence in the blood pool. This study highlights novel nano-formulations used as efficient contrast agents for preclinical X-ray imaging applications, along with simple and efficient alternatives for the generation of iodinated nano-emulsions.
Référence
. 2011;1(5):792-801.
