Fiche publication
Date publication
avril 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FEUGIER Pierre
Tous les auteurs :
Kridel R, Xerri L, Gelas-Dore B, Tan K, Feugier P, Vawda A, Canioni D, Farinha P, Boussetta S, Moccia AA, Brice P, Chavez EA, Kyle AH, Scott DW, Sanders A, Fabiani B, Slack G, Minchinton AI, Haioun C, Connors JM, Sehn L, Steidl C, Gascoyne RD, Salles G
Lien Pubmed
Résumé
PURPOSE: We aimed to assess the prognostic significance of follicular lymphoma (FL)-associated macrophages in the era of rituximab treatment and maintenance. EXPERIMENTAL DESIGN: We applied IHC for CD68 and CD163 to two large tissue microarrays (TMAs). The first TMA included samples from 186 patients from the BC Cancer Agency (BCCA) who had been treated with first line systemic treatment including rituximab, cyclophosphamide, vincristine and prednisone. The second contained 395 samples from PRIMA trial patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, and randomized to rituximab maintenance or observation. Macrophage infiltration was assessed using Aperio image analysis. Each of the two cohorts was randomly split into training/validation sets. RESULTS: An increased CD163 positive pixel count was predictive of adverse outcome in the BCCA dataset (5-year progression-free survival (PFS) 38% v 72%, respectively, P=0.004 in the training cohort and 5-year PFS 29% v 61%, respectively, P=0.004 in the validation cohort). In the PRIMA trial, an increased CD163 pixel count was associated with favourable outcome (5-year PFS 60% v 44%, respectively, P=0.011 in the training cohort and 5-year PFS 55% v 37%, respectively, P=0.030 in the validation cohort). CONCLUSION: CD163-positive macrophages predict outcome in FL but their prognostic impact is highly dependent on treatment received.
Référence
Clin Cancer Res. 2015 Apr 13. pii: clincanres.3253.2014.
