Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.

Date publication

novembre 2010

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FOURNEL Sylvie

Tous les auteurs :
Gorska K, Beyrath J, Fournel S, Guichard G, Winssinger N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/20852806

Résumé

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.

Référence

Chem Commun (Camb). 2010 Nov 7;46(41):7742-4