Fiche publication
Date publication
octobre 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NOEL Georges
Tous les auteurs :
Noel G, Mazeron JJ
Lien Pubmed
Résumé
The purpose of this review was to analyze data available on reirradiation for high-grade glioma or brain metastasis. This reirradiation can be 3D conformal or stereotactic. There are no randomized trials. No definitive recommendations can be given but solutions can be proposed. In high-grade gliomas, results of 3D conformal irradiation are fair. Stereotactic irradiation produces more encouraging survival rates but the range of doses delivered is too large for allowing recommendations. However, fractions less than 5Gy seem better tolerated. In brain metastases, total brain irradiation seems useful if metastases are multiple and the patient in good condition. With radiosurgery, local control rates are high and survival encouraging. In a retrospective study, bifractionated irradiation looked interesting when compared to radiosurgery. Overall prospective trials seem to be necessary.
Référence
Cancer Radiother. 2010 Oct;14(6-7):421-37
