Fiche publication
Date publication
septembre 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANSELME Karine
Tous les auteurs :
Giljean S, Ponche A, Bigerelle M, Anselme K
Lien Pubmed
Résumé
Our objective in this work was to determine statistically the relative influence of surface topography and surface chemistry of metallic substrates on long-term adhesion of human bone cell quantified by the adhesion power (AP). Pure titanium, titanium alloy, and stainless steel substrates were processed with electro-erosion, sandblasting, or polishing giving various morphologies and amplitudes. The surface chemistry was characterized by X-ray photoelectron spectroscopy (XPS) associated with an extensive analysis of surface topography. The statistical analysis demonstrated that the effect on AP of the material composition was not significant. More, no correlation was found between AP and the surface element concentrations determined by XPS demonstrating that the surface chemistry was not an influencing parameter for long-term adhesion. In the same way, the roughness amplitude, independently of the process, had no influence on AP, meaning that roughness amplitude is not an intrinsic parameter of long-term adhesion. On the contrary, the elaboration process alone had a significant effect on AP. For a same surface elaboration process, the number of inflexion points, or G parameter, was the most pertinent roughness parameter for describing the topography influence on long-term adhesion. Thus, more the inflexion points, more the discontinuities, higher the long-term adhesion.
Référence
J Biomed Mater Res A. 2010 Sep 15;94(4):1111-23.
