Fiche publication
Date publication
août 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard
Tous les auteurs :
Slodkowska EA, Cribier B, Peltre B, Jones DM, Carlson JA
Lien Pubmed
Résumé
BACKGROUND: Carcinoma-associated calcifications (Ca(2+)) are a common phenomenon. In the skin, basal cell carcinomas (BCC) can be associated with Ca(2+). OBJECTIVE: To examine the prevalence, characteristics, and clinicopathologic correlations of BCC associated with Ca(2+). MATERIAL AND METHODS: Eighty-three BCC with Ca(2+) were retrieved, 27 (11.1%) of which were identified from a review of 243 consecutive BCC. Ca(2+) were classified into 4 types: type 1, Ca(2+) within BCC epithelium; type 2, Ca(2+) in BCC keratocysts; type 3, BCC tumor necrosis with Ca(2+); and type 4, free Ca(2+) adjacent to BCC. Clinical and pathologic features were assessed and compared with BCC without Ca(2+). Expression of hair-associated proteins (hair keratins (K31, K32, and K35) and matrical transcription factors (LEF1, HOXC13, and beta-catenin) were examined in a subset of BCC with Ca(2+) and compared with matched controls without Ca(2+). RESULTS: Compared with BCC without Ca(2+), BCC with Ca(2+) were significantly more likely to show a nodular keratinizing phenotype with keratocyst formation, background solar elastosis, active regression, and areas of tumor necrosis (all P
Référence
Am J Dermatopathol. 2010 Aug;32(6):557-64.
