Fiche publication
Date publication
août 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NUZILLARD Jean-Marc
Tous les auteurs :
Mulholland DA, Langat MK, Crouch NR, Coley HM, Mutambi EM, Nuzillard JM
Lien Pubmed
Résumé
The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-ol ide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.
Référence
Phytochemistry. 2010 Aug;71(11-12):1381-6
