Fiche publication
Date publication
juin 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VANDERESSE Régis
Tous les auteurs :
Chiewpattanakul P, Covis R, Vanderesse R, Thanomsub B, Marie E, Durand A
Résumé
Dextran-covered nanoparticles were produced by two different processes: emulsion/solvent evaporation and nanoprecipitation for the encapsulation of monomyristin. The inner core was formed by poly(lactic acid) or by a hydrophobically modified dextran (carrying n-decyl chains). According to the core materials and/or to the process, the average size of nanoparticles as well as the extent of aggregate formation was modulated. It was shown that the presence of monomyristin induced significant modifications on the characteristics of the resulting suspension (size and aggregate formation). Varying the matrix polymer as well as the amount of monomyristin in the feed allowed obtaining nanoparticles with convenient size. The use of hydrophobically modified dextran as the matrix material appeared promising.
Référence
Colloid Polym Sci. 2010 Jun;288(9):959-67
