fr

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fr

EN DE

Dr ENNIFAR Eric

Fiche personne

coordonnées

IBMC
2 allée Conrad Roentgen
67084 STRASBOURG

03 88 41 70 01

e.ennifar@unistra.fr

Territoire

Alsace

Statut

Chercheur

affiliation

IBMC - Institut de biologie moléculaire et cellulaire (IBMC)

équipes/plateformes

Equipe CNRS UPR 9002 - Equipe "Architecture et réactivité de l'ARN / Structure, dynamique et ciblage des machines biomoléculaires"

Plateforme Molecular Biophysics Facility Strasbourg

Recherche

Mots clés : Biologie moléculaire,Biologie structurale,Biophysique

Thématique de recherche :

Structure et dynamique des machines biomoléculaires

Publications

Structural analysis of neomycin B and kanamycin A binding Aminoglycosides Modifying Enzymes (AME) and bacterial ribosomal RNA.

Revillo Imbernon J, Weibel JM, Ennifar E, Prévost G, Kellenberger E

Mol Inform. 2024 06 10;:e202300339

Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism.

D'Agostino M, Simonetti A, Motta S, Wolff P, Romagnoli A, Piccinini A, Spinozzi F, Di Marino D, La Teana A, Ennifar E

Structure. 2024 03 27;:

Characterization of SLA RNA promoter from dengue virus and its interaction with the viral non-structural NS5 protein.

Brillet K, Janczuk-Richter M, Poon A, Laukart-Bradley J, Ennifar E, Lebars I

Biochimie. 2024 02 24;:

Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.

Patel AKM, Vilela P, Shaik TB, McEwen AG, Hazemann I, Brillet K, Ennifar E, Hamiche A, Markov GV, Laudet V, Moras D, Klaholz BP, Billas IML

Nucleic Acids Res. 2023 07 28;:

CspA stimulates translation in the cold of its own mRNA by promoting ribosome progression.

Giuliodori AM, Belardinelli R, Duval M, Garofalo R, Schenckbecher E, Hauryliuk V, Ennifar E, Marzi S

Front Microbiol. 2023 02 9;14:1118329

Efficient production of protein complexes in mammalian cells using a poxvirus vector.

Drillien R, Pradeau-Aubreton K, Batisse J, Mezher J, Schenckbecher E, Marguin J, Ennifar E, Ruff M

PLoS One. 2022 12 15;17(12):e0279038

Safe and easy in vitro evaluation of tmRNA-SmpB-mediated trans-translation from ESKAPE pathogenic bacteria.

Thepaut M, Campos-Silva R, Renard E, Barloy-Hubler F, Ennifar E, Boujard D, Gillet R

RNA. 2021 Aug 5;:

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination.

Ramos-Morales E, Bayam E, Del-Pozo-Rodríguez J, Salinas-Giegé T, Marek M, Tilly P, Wolff P, Troesch E, Ennifar E, Drouard L, Godin JD, Romier C

Nucleic Acids Res. 2021 May 31;:

Impact of 3-deazapurine nucleobases on RNA properties.

Bereiter R, Himmelstoß M, Renard E, Mairhofer E, Egger M, Breuker K, Kreutz C, Ennifar E, Micura R

Nucleic Acids Res. 2021 Apr 15;:

Biophysical Studies of the Binding of Viral RNA with the 80S Ribosome Using switchSENSE.

Schenckbecher E, Bec G, Sakamoto T, Meyer B, Ennifar E

Methods Mol Biol. 2021 ;2263:341-350

switchSENSE Technology for Analysis of DNA Polymerase Kinetics.

Bec G, Ennifar E

Methods Mol Biol. 2021 ;2247:145-153

Deflating the RNA Mg bubble. Stereochemistry to the rescue!

Auffinger P, Ennifar E, D'Ascenzo L

RNA. 2020 Dec 2;:

2'--Trifluoromethylated RNA - a powerful modification for RNA chemistry and NMR spectroscopy.

Himmelstoß M, Erharter K, Renard E, Ennifar E, Kreutz C, Micura R

Chem Sci. 2020 Sep 24;11(41):11322-11330

Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA.

Brillet K, Martinez-Zapien D, Bec G, Ennifar E, Dock-Bregeon AC, Lebars I

RNA. 2020 May 19;:

Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.

Werner S, Schmidt L, Marchand V, Kemmer T, Falschlunger C, Sednev MV, Bec G, Ennifar E, Höbartner C, Micura R, Motorin Y, Hildebrandt A, Helm M

Nucleic Acids Res.. 2020 Feb 25;:

Thioguanosine conversion enables mRNA life-time evaluation by RNA sequencing via double metabolic labeling.

Gasser C, Delazer I, Neuner E, Pascher K, Brillet K, Klotz S, Trixl L, Himmelstoß M, Ennifar E, Rieder D, Lusser A, Micura R

Angew. Chem. Int. Ed. Engl.. 2020 Jan 30;:

Analysis of the HIV-1 Genomic RNA Dimerization Initiation Site Binding to Aminoglycoside Antibiotics Using Isothermal Titration Calorimetry.

Bernacchi S, Ennifar E

Methods Mol. Biol.. 2020 ;2113:237-250

Native Electrospray Ionization Mass Spectrometry of RNA-Ligand Complexes.

Wolff P, Ennifar E

Methods Mol. Biol.. 2020 ;2113:111-118

AFFINImeter: A software to analyze molecular recognition processes from experimental data.

Piñeiro Á, Muñoz E, Sabín J, Costas M, Bastos M, Velázquez-Campoy A, Garrido PF, Dumas P, Ennifar E, García-Río L, Rial J, Pérez D, Fraga P, Rodríguez A, Cotelo C

Anal. Biochem.. 2019 Mar 5;:

ITC Studies of Ribosome/Antibiotics Interactions.

Schenckbecher E, Meyer B, Ennifar E

Methods Mol. Biol.. 2019 ;1964:89-98

Thermodynamic and Kinetic Analysis of Isothermal Titration Calorimetry Experiments by Using KinITC in AFFINImeter.

Muñoz E, Sabín J, Rial J, Pérez D, Ennifar E, Dumas P, Piñeiro Á

Methods Mol. Biol.. 2019 ;1964:225-239

Thermodynamics of Molecular Machines Using Incremental ITC.

Meyer B, da Veiga C, Dumas P, Ennifar E

Methods Mol. Biol.. 2019 ;1964:129-140

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants.

Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos Morales E, Da Veiga C, Kalinin DV, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce R, Jung M, Sippl W, Romier C

J. Med. Chem.. 2018 Oct 22;:

Thermodynamic study of aptamers binding to their target proteins.

Sakamoto T, Ennifar E, Nakamura Y

Biochimie. 2018 Feb;145:91-97

Crystal structure and fluorescence properties of the iSpinach aptamer in complex with DFHBI.

Fernandez-Millan P, Autour A, Ennifar E, Westhof E, Ryckelynck M

RNA. 2017 12;23(12):1788-1795

Nucleic acid nanomaterials: Silver-wired DNA.

Auffinger P, Ennifar E

Nat Chem. 2017 Sep 22;9(10):932-934

Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine.

Riml C, Lusser A, Ennifar E, Micura R

J. Org. Chem.. 2017 Aug 4;82(15):7939-7945

Native ESI Mass Spectrometry Can Help to Avoid Wrong Interpretations from Isothermal Titration Calorimetry in Difficult Situations.

Wolff P, Da Veiga C, Ennifar E, Bec G, Guichard G, Burnouf D, Dumas P

J. Am. Soc. Mass Spectrom.. 2017 Feb;28(2):347-357

Multianalytical Study of the Binding between a Small Chiral Molecule and a DNA Aptamer: Evidence for Asymmetric Steric Effect upon 3'- versus 5'-End Sequence Modification.

Challier L, Miranda-Castro R, Barbe B, Fave C, Limoges B, Peyrin E, Ravelet C, Fiore E, Labbé P, Coche-Guérente L, Ennifar E, Bec G, Dumas P, Mavré F, Noël V

Anal. Chem.. 2016 Dec 6;88(23):11963-11971

Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

Latrick CM, Marek M, Ouararhni K, Papin C, Stoll I, Ignatyeva M, Obri A, Ennifar E, Dimitrov S, Romier C, Hamiche A

Nat. Struct. Mol. Biol.. 2016 Apr;23(4):309-16

Extending ITC to Kinetics with kinITC.

Dumas P, Ennifar E, Da Veiga C, Bec G, Palau W, Di Primo C, Piñeiro A, Sabin J, Muñoz E, Rial J

Meth. Enzymol.. 2016 ;567:157-80

Isothermal Titration Calorimetry: Assisted Crystallization of RNA-Ligand Complexes.

Da Veiga C, Mezher J, Dumas P, Ennifar E

Methods Mol. Biol.. 2016 ;1320:127-43

Quantitative and predictive model of kinetic regulation by E. coli TPP riboswitches.

Guedich S, Puffer-Enders B, Baltzinger M, Hoffmann G, Da Veiga C, Jossinet F, Thore S, Bec G, Ennifar E, Burnouf D, Dumas P

RNA Biol. 2016 ;13(4):373-90

Sodium and Potassium Interactions with Nucleic Acids.

Auffinger P, D'Ascenzo L, Ennifar E

Met Ions Life Sci. 2016 ;16:167-201

Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis.

Koch M, Flür S, Kreutz C, Ennifar E, Micura R, Polacek N

Proc. Natl. Acad. Sci. U.S.A.. 2015 May 19;112(20):E2561-8

kinITC: a new method for obtaining joint thermodynamic and kinetic data by isothermal titration calorimetry.

Burnouf D, Ennifar E, Guedich S, Puffer B, Hoffmann G, Bec G, Disdier F, Baltzinger M, Dumas P

J. Am. Chem. Soc.. 2012 Jan 11;134(1):559-65

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants.

Radi M, Maga G, Alongi M, Angeli L, Samuele A, Zanoli S, Bellucci L, Tafi A, Casaluce G, Giorgi G, Armand-Ugon M, Gonzalez E, Esté JA, Baltzinger M, Bec G, Dumas P, Ennifar E, Botta M

J. Med. Chem.. 2009 Feb 12;52(3):840-51

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