EN DE

Dr DUMORTIER Hélène

Fiche personne

coordonnées

IBMC
2 allée Konrad Roentgen
67084 STRASBOURG Cedex

03 88 61 70 22

h.dumortier@ibmc-cnrs.unistra.fr

Territoire

Alsace

Statut

Chercheur

affiliation

IBMC - Institut de biologie moléculaire et cellulaire (IBMC)

équipes/plateformes

Equipe CNRS UPR 3572 - Equipe "Immunologie, Immunopathologie et Chimie Thérapeutique (I2CT) / Mécanismes physiopathologiques et régulation thérapeutique des réponses auto-immunes"

Recherche

Thématique de recherche :

Mécanismes physiopathologiques et régulation thérapeutique des réponses auto-immunes

Publications

Efficacy of BAFF inhibition and B-cell depletion in non-obese diabetic mice as a spontaneous model for Sjögren's disease.

Felten R, Foray AP, Schneider P, Marquet C, Pecquet C, Monneaux F, Dumortier H, Sibilia J, Valette F, Chatenoud L, Gottenberg JE

RMD Open. 2024 08 28;10(3):

Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren's syndrome.

Kawka L, Felten R, Schleiss C, Fauny JD, Le Van Quyen P, Dumortier H, Monneaux F, Gottenberg JE

RMD Open. 2023 05;9(2):

Identification of new candidate drugs for primary Sjögren's syndrome using a drug repurposing transcriptomic approach.

Felten R, Ye T, Schleiss C, Schwikowski B, Sibilia J, Monneaux F, Dumortier H, Jonsson R, Lessard C, Ng F, Takeuchi T, Mariette X, Gottenberg JE

Rheumatology (Oxford). 2023 03 3;:

Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice.

Kraemer AN, Schäfer AL, Sprenger DTL, Sehnert B, Williams JP, Luo A, Riechert L, Al-Kayyal Q, Dumortier H, Fauny JD, Winter Z, Heim K, Hofmann M, Herrmann M, Heine G, Voll RE, Chevalier N

Front Immunol. 2022 11 24;13:933191

Variability in primary Sjögren's syndrome is driven by interferon alpha, and genetically associated with the class II HLA DQ locus.

Trutschel D, Bost P, Mariette X, Bondet V, Llibre A, Posseme C, Charbit B, Thorball CW, Jonsson R, Lessard CJ, Felten R, Ng WF, Chatenoud L, Dumortier H, Sibilia J, Fellay J, Brokstad KA, Appel S, Tarn Dr JR, Murci LQ, Mingueneau M, Meyer N, Duffy D, Schwikowski B, Gottenberg JE,

Arthritis Rheumatol. 2022 06 20;:

Selectins impair regulatory T cell function and contribute to systemic lupus erythematosus pathogenesis.

Scherlinger M, Guillotin V, Douchet I, Vacher P, Boizard-Moracchini A, Guegan JP, Garreau A, Merillon N, Vermorel A, Ribeiro E, Machelart I, Lazaro E, Couzi L, Duffau P, Barnetche T, Pellegrin JL, Viallard JF, Saleh M, Schaeverbeke T, Legembre P, Truchetet ME, Dumortier H, Contin-Bordes C, Sisirak V, Richez C, Blanco P

Sci Transl Med. 2021 Jun 30;13(600):

Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.

Murdamoothoo D, Sun Z, Yilmaz A, Riegel G, Abou-Faycal C, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Veber R, Dumortier H, Yuan J, Midwood KS, Loustau T, Orend G

EMBO Mol Med. 2021 May 14;:e13270

The "French Germinal Center Club" of the French Society for Immunology: a dynamic collaboration between researchers passionate about the germinal center reaction.

Amé P, Dumortier H, Espéli M, Milpied P, Fazilleau N

Eur J Immunol. 2021 Feb;51(2):270-271

High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease.

Aubergeon L, Sawaf M, Felten R, Gottenberg JE, Dumortier H, Monneaux F

Front Immunol. 2021 ;12:767099

Tenascin-C orchestrates an immune suppressive tumor microenvironment in oral squamous cell carcinoma.

Spenlé C, Loustau T, Murdamoothoo D, Erne W, Beghelli-de la Forest Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Crémel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuere F, Van Obberghen-Schilling E, Orend G

Cancer Immunol Res. 2020 Jul 14;:

Few Layer Graphene Does Not Affect Cellular Homeostasis of Mouse Macrophages.

Malanagahalli S, Murera D, Martín C, Lin H, Wadier N, Dumortier H, Vázquez E, Bianco A

Nanomaterials (Basel). 2020 Jan 28;10(2):

Few layer graphene does not affect the function and the autophagic activity of primary lymphocytes.

Murera D, Malaganahalli S, Martín C, Reina G, Fauny JD, Dumortier H, Vázquez E, Bianco A

Nanoscale. 2019 May 21;:

Defective BTLA functionality is rescued by restoring lipid metabolism in lupus CD4+ T cells.

Sawaf M, Fauny JD, Felten R, Sagez F, Gottenberg JE, Dumortier H, Monneaux F

JCI Insight. 2018 Jul 12;3(13):

Identification of autoreactive B cells with labeled nucleosomes.

Gies V, Wagner A, Seifert C, Guffroy A, Fauny JD, Knapp AM, Pasquali JL, Martin T, Dumortier H, Korganow AS, Soulas-Sprauel P

Sci Rep. 2017 Apr;7(1):602

Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?

Sawaf M, Dumortier H, Monneaux F

J Immunol Res. 2016 ;2016:5767106

OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.

Jacquemin C, Schmitt N, Contin-Bordes C, Liu Y, Narayanan P, Seneschal J, Maurouard T, Dougall D, Davizon ES, Dumortier H, Douchet I, Raffray L, Richez C, Lazaro E, Duffau P, Truchetet ME, Khoryati L, Mercié P, Couzi L, Merville P, Schaeverbeke T, Viallard JF, Pellegrin JL, Moreau JF, Muller S, Zurawski S, Coffman RL, Pascual V, Ueno H, Blanco P

Immunity. 2015 Jun;42(6):1159-70

Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells.

Russier J, Treossi E, Scarsi A, Perrozzi F, Dumortier H, Ottaviano L, Meneghetti M, Palermo V, Bianco A

Nanoscale. 2013 Nov 21;5(22):11234-47

Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons.

Lamanna G, Russier J, Dumortier H, Bianco A

Biomaterials. 2012 Aug;33(22):5610-7

Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes.

Lacerda L, Russier J, Pastorin G, Herrero MA, Venturelli E, Dumortier H, Al-Jamal KT, Prato M, Kostarelos K, Bianco A

Biomaterials. 2012 Apr;33(11):3334-43

Ex vivo impact of functionalized carbon nanotubes on human immune cells.

Delogu LG, Venturelli E, Manetti R, Pinna GA, Carru C, Madeddu R, Murgia L, Sgarrella F, Dumortier H, Bianco A

Nanomedicine (Lond). 2012 Feb;7(2):231-43

Carbon nanotube-coupled cell adhesion peptides are non-immunogenic: a promising step toward new biomedical devices.

Gaillard C, Duval M, Dumortier H, Bianco A

J. Pept. Sci.. 2011 Feb;17(2):139-42

Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection.

Habib M, Rivas MN, Chamekh M, Wieckowski S, Sun W, Bianco A, Trouche N, Chaloin O, Dumortier H, Goldman M, Guichard G, Fournel S, Vray B

J Immunol. 2007 Jun 1;178(11):6700-4.

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells.

Dumortier H, Lacotte S, Pastorin G, Marega R, Wu W, Bonifazi D, Briand JP, Prato M, Muller S, Bianco A

Nano Lett.. 2006 Jul;6(7):1522-8

C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.

Fournel S, Wieckowski S, Sun W, Trouche N, Dumortier H, Bianco A, Chaloin O, Habib M, Peter JC, Schneider P, Vray B, Toes RE, Offringa R, Melief CJ, Hoebeke J, Guichard G

Nat Chem Biol. 2005 Dec;1(7):377-82.