Détail - canceropole-wordpress

Identification of a novel DNA oxidative damage repair pathway, requiring the ubiquitination of the histone variant macroH2A1.1.

Ouararhni K, Mietton F, Sabir JSM, Ibrahim A, Molla A, Albheyri RS, Zari AT, Bahieldin A, Menoni H, Bronner C, Dimitrov S, Hamiche A

BMC Biol. 2024 09 2;22(1):188

UHRF1 poly-auto-ubiquitination induced by the anti-cancer drug, thymoquinone, is involved in the DNA repair machinery recruitment.

Almalki NAR, Sabir JSM, Ibrahim A, Alhosin M, Asseri AH, Albiheyri RS, Zari AT, Bahieldin A, Javed A, Mély Y, Hamiche A, Mousli M, Bronner C

Int J Biochem Cell Biol. 2024 04 20;:106582

Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.

Ignatyeva M, Patel AKM, Ibrahim A, Albiheyri RS, Zari AT, Bahieldin A, Bronner C, Sabir JSM, Hamiche A

Cells. 2024 02 1;13(3):

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.

Papin C, Ibrahim A, Sabir JSM, Le Gras S, Stoll I, Albiheyri RS, Zari AT, Bahieldin A, Bellacosa A, Bronner C, Hamiche A

J Exp Clin Cancer Res. 2023 11 14;42(1):301

Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1.

Ashraf W, Ahmad T, Reynoird N, Hamiche A, Mély Y, Bronner C, Mousli M

Molecules. 2023 08 10;28(16):

Tannin extract from maritime pine bark exhibits anticancer properties by targeting the epigenetic UHRF1/DNMT1 tandem leading to the re-expression of .

Ashraf W, Ahmad T, Almalki NAR, Krifa M, Zaayter L, Pizzi A, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Food Funct. 2021 Dec 13;:

TIP60 governs the auto‑ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex.

Ahmad T, Ashraf W, Ibrahim A, Zaayter L, Muller CD, Hamiche A, Mély Y, Bronner C, Mousli M

Int J Oncol. 2021 Nov;59(5):

MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion.

Ibrahim A, Papin C, Mohideen-Abdul K, Le Gras S, Stoll I, Bronner C, Dimitrov S, Klaholz BP, Hamiche A

Science. 2021 Jun 25;372(6549):

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex.

Abdullah O, Omran Z, Hosawi S, Hamiche A, Bronner C, Alhosin M

Genes (Basel). 2021 Apr 22;12(5):

ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the , MIF Immune Susceptibility Locus.

Yao J, Leng L, Fu W, Li J, Bronner C, Bucala R

Arthritis Rheumatol. 2021 Apr 12;:

CpG Islands Shape the Epigenome Landscape.

Papin C, Le Gras S, Ibrahim A, Salem H, Karimi MM, Stoll I, Ugrinova I, Schröder M, Fontaine-Pelletier E, Omran Z, Bronner C, Dimitrov S, Hamiche A

. 2020 Sep 30;:

A molecular tool targeting the base flipping activity of human UHRF1.

Zaayter L, Mori M, Ahmad T, Ashraf W, Boudier C, Kilin V, Gavvala K, Richert L, Eiler S, Ruff M, Botta M, Bronner C, Mousli M, Mely Y

Chemistry. 2019 Jul 19;:

Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns.

Bronner C, Alhosin M, Hamiche A, Mousli M

Genes (Basel). 2019 Jan 18;10(1):

Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line.

Hasan MN, Razvi SS, Choudhry H, Hassan MA, Moselhy SS, Kumosani TA, Zamzami MA, Abualnaja KO, Halwani MA, Al-Malki AL, Ragoussis J, Wu W, Bronner C, Asami T, Alhosin M

Anal Cell Pathol (Amst). 2019 ;2019:1598182

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells.

Ibrahim A, Alhosin M, Papin C, Ouararhni K, Omran Z, Zamzami MA, Al-Malki AL, Choudhry H, Mély Y, Hamiche A, Mousli M, Bronner C

Oncotarget. 2018 Jun 19;9(47):28599-28611

Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N-Erucoyl Spermidine.

Razvi SS, Choudhry H, Hasan MN, Hassan MA, Moselhy SS, Abualnaja KO, Zamzami MA, Kumosani TA, Al-Malki AL, Halwani MA, Ibrahim A, Hamiche A, Bronner C, Asami T, Alhosin M

Epigenet Insights. 2018 ;11:2516865718814543

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy.

Choudhry H, Zamzami MA, Omran Z, Wu W, Mousli M, Bronner C, Alhosin M

Oncol Lett. 2018 Jan;15(1):3-10

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell.

Ashraf W, Bronner C, Zaayter L, Ahmad T, Richert L, Alhosin M, Ibrahim A, Hamiche A, Mely Y, Mousli M

J. Exp. Clin. Cancer Res.. 2017 12 21;36(1):188

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.

Ashraf W, Ibrahim A, Alhosin M, Zaayter L, Ouararhni K, Papin C, Ahmad T, Hamiche A, Mély Y, Bronner C, Mousli M

Oncotarget. 2017 Aug;8(31):51946-51962

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer.

Ashraf W, Ibrahim A, Alhosin M, Zaayter L, Ouararhni K, Papin C, Ahmad T, Hamiche A, Mély Y, Bronner C, Mousli M

Oncotarget. 2017 Apr;:

Combinatorial DNA methylation codes at repetitive elements.

Papin C, Ibrahim A, Le Gras S, Velt A, Jost B, Stoll I, Menoni H, Bronner C, Dimitrov S, Hamiche A

Genome Res.. 2017 Mar;:

Dynamics of Methylated Cytosine Flipping by UHRF1.

Kilin V, Gavvala K, Barthes NP, Michel BY, Shin D, Boudier C, Mauffret O, Yashchuk V, Mousli M, Ruff M, Granger F, Eiler S, Bronner C, Tor Y, Burger A, Mély Y

J. Am. Chem. Soc.. 2017 Feb;139(6):2520-2528

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer.

Alhosin M, Omran Z, Zamzami MA, Al-Malki AL, Choudhry H, Mousli M, Bronner C

J. Exp. Clin. Cancer Res.. 2016 Nov;35(1):174

Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation.

Myrianthopoulos V, Cartron PF, Liutkevičiūtė Z, Klimašauskas S, Matulis D, Bronner C, Martinet N, Mikros E

Eur J Med Chem. 2016 May;114:390-6

Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

Greiner VJ, Kovalenko L, Humbert N, Richert L, Birck C, Ruff M, Zaporozhets OA, Dhe-Paganon S, Bronner C, Mely Y

Biochemistry. 2015 Sep 23.

CD47 activation-induced UHRF1 over-expression is associated with silencing of tumor suppressor gene p16INK4A in glioblastoma cells.

Boukhari A, Alhosin M, Bronner C, Sagini K, Truchot C, Sick E, Schini-Kerth VB, Andre P, Mely Y, Mousli M, Gies JP

Anticancer Res. 2015 Jan;35(1):149-57.

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis.

Bronner C, Krifa M, Mousli M

Biochem Pharmacol. 2013 Dec 15;86(12):1643-9

Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins.

Yu CY, Xing FY, Tang ZL, Bronner C, Lu XJ, Di JF, Zeng S, Liu J

Pharmacol Rep. 2013 Mar-apr;65(2):435-44.

Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins.

Yu C, Xing F, Tang Z, Bronner C, Lu X, Di J, Zeng S, Liu J

Pharmacol Rep. 2013;65(2):435-44.

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2013 Jan 4;430(1):208-12

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.

Krifa M, Alhosin M, Muller CD, Gies JP, Chekir-Ghedira L, Ghedira K, Mely Y, Bronner C, Mousli M

J Exp Clin Cancer Res. 2013 May 20;32:30

Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.

Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C

Biochem Biophys Res Commun. 2012 Jul 3.

Red wine polyphenols improve an established aging-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress.

Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB

Biochem Biophys Res Commun. 2012 Mar 9;419(2):381-7

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB

PLoS One. 2012;7(3):e32526

Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.

Nady N, Lemak A, Walker JR, Avvakumov GV, Kareta MS, Achour M, Xue S, Duan S, Allali-Hassani A, Zuo X, Wang YX, Bronner C, Chedin F, Arrowsmith CH, Dhe-Paganon S

J Biol Chem. 2011 Jul 8;286(27):24300-11

Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.

Sharif T, Auger C, Bronner C, Alhosin M, Klein T, Etienne-Selloum N, Schini-Kerth VB, Fuhrmann G

Invest New Drugs. 2011 Apr;29(2):239-47

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase.

Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB

Biochem Biophys Res Commun. 2011 Jan 14;404(2):743-9

Control of DNMT1 abundance in epigenetic inheritance by acetylation, ubiquitylation, and the histone code.

Bronner C

Sci Signal. 2011 Jan 25;4(157):pe3.

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C

Cell Signal. 2011 Jan;23(1):152-60

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties.

Alhosin M, Sharif T, Mousli M, Etienne-Selloum N, Fuhrmann G, Schini-Kerth VB, Bronner C

J Exp Clin Cancer Res. 2011 Apr 15;30:41.

Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.

Walter A, Etienne-Selloum N, Brasse D, Khallouf H, Bronner C, Rio MC, Beretz A, Schini-Kerth VB

FASEB J. 2010 Sep;24(9):3360-9

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, Peluso J, Chataigneau T, Lugnier C, Schini-Kerth VB, Bronner C, Fuhrmann G

Biochem Pharmacol. 2010 May 1;79(9):1251-60

Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats.

Dal-Ros S, Oswald-Mammosser M, Pestrikova T, Schott C, Boehm N, Bronner C, Chataigneau T, Geny B, Schini-Kerth VB

Gastroenterology. 2010 Apr;138(4):1574-84

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.

Sharif T, Auger C, Alhosin M, Ebel C, Achour M, Etienne-Selloum N, Fuhrmann G, Bronner C, Schini-Kerth VB

Eur J Cancer. 2010 Mar;46(5):983-94

Dipyrrin based luminescent cyclometallated palladium and platinum complexes

Bronner C, Baudron SA, Hosseini MW, Strassert CA, Guenet A, De Cola L

Dalton Trans. 2010 Jan 7;(1):180-4

UHRF1 Links the Histone code and DNA Methylation to ensure Faithful Epigenetic Memory Inheritance.

Bronner C, Fuhrmann G, Chédin FL, Macaluso M, Dhe-Paganon S

Genet Epigenet. 2010 Jan;2009(2):29-36

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity.

Achour M, Fuhrmann G, Alhosin M, Ronde P, Chataigneau T, Mousli M, Schini-Kerth VB, Bronner C

Biochem Biophys Res Commun. 2009 Dec 18;390(3):523-8

Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.

Zerr-Fouineau M, Jourdain M, Boesch C, Hecker M, Bronner C, Schini-Kerth VB

Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):586-93

Crataegus special extract WS 1442 causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of endothelial NO synthase but not via activation of estrogen receptors.

Anselm E, Socorro VF, Dal-Ros S, Schott C, Bronner C, Schini-Kerth VB

J Cardiovasc Pharmacol. 2009 Mar;53(3):253-60.

Angiotensin II-induced hypertension is associated with a selective inhibition of endothelium-derived hyperpolarizing factor-mediated responses in the rat mesenteric artery.

Dal-Ros S, Bronner C, Schott C, Kane MO, Chataigneau M, Schini-Kerth VB, Chataigneau T

J Pharmacol Exp Ther. 2009 Feb;328(2):478-86

ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells.

Fang Z, Xing F, Bronner C, Teng Z, Guo Z

Cell Immunol. 2009;257(1-2):80-7

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.

Avvakumov GV, Walker JR, Xue S, Li Y, Duan S, Bronner C, Arrowsmith CH, Dhe-Paganon S

Nature. 2008 Oct 9;455(7214):822-5

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression.

Achour M, Jacq X, Ronde P, Alhosin M, Charlot C, Chataigneau T, Jeanblanc M, Macaluso M, Giordano A, Hughes AD, Schini-Kerth VB, Bronner C

Oncogene. 2008 Apr 3;27(15):2187-97

A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.

Unoki M, Bronner C, Mousli M

Radiat Res. 2008 Feb;169(2):240-4.

The UHRF family: oncogenes that are drugable targets for cancer therapy in the near future?

Bronner C, Achour M, Arima Y, Chataigneau T, Saya H, Schini-Kerth VB

Pharmacol Ther. 2007 Sep;115(3):419-34

Epigenetic modulation of estrogen receptor-alpha by pRb family proteins: a novel mechanism in breast cancer.

Macaluso M, Montanari M, Noto PB, Gregorio V, Bronner C, Giordano A

Cancer Res. 2007 Aug 15;67(16):7731-7.

The "epigenetic, code replication machinery", ECREM: A promising drugable target of the epigenetic cell memory

Bronner C, Chataigneau T, Schini-Kerth VB, Landry Y

Curr Med Chem. 2007;14(25):2629-41.

Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity.

Un F, Qi C, Prosser M, Wang N, Zhou B, Bronner C, Yen Y

Anticancer Res. 2006 Jul-Aug;26(4B):2761-7.

The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle.

Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, Abbady AQ, Siffert JC, Mathieu E, Muller CD, Bronner C

Oncogene. 2005 Nov 10;24(49):7337-45.

Cell cycle and/or proliferation markers: what is the best method to discriminate cervical high-grade lesions?

Lorenzato M, Caudroy S, Bronner C, Evrard G, Simon M, Durlach A, Birembaut P, Clavel C

Hum Pathol. 2005 Oct;36(10):1101-7.

Is the upregulation of bradykinin B2 receptors by TGF-beta1 one of the missing pieces in the "airway hyperresponsiveness" puzzle?

Bronner C

Am J Physiol Lung Cell Mol Physiol. 2005 Oct;289(4):L509-10.

Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression.

Hopfner R, Mousli M, Garnier JM, Redon R, du Manoir S, Chatton B, Ghyselinck N, Oudet P, Bronner C

Gene. 2001 Mar 21;266(1-2):15-23.

Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression.

Hopfner R, Mousli M, Oudet P, Bronner C

Anticancer Res.. ;22(6A):3165-70

Dr BRONNER Christian

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