Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.
Fiche publication
Date publication
décembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline
Tous les auteurs :
Secret E, Maynadier M, Gallud A, Chaix A, Bouffard E, Gary-Bobo M, Marcotte N, Mongin O, El Cheikh K, Hugues V, Auffan M, Frochot C, Morere A, Maillard P, Blanchard-Desce M, Sailor MJ, Garcia M, Durand JO, Cunin F
Lien Pubmed
Résumé
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
Référence
Adv Mater. 2014 Dec 3;26(45):7643-8