Overall Survival Prediction and Usefulness of Second-Line Chemotherapy in Advanced Pancreatic Adenocarcinoma.

Fiche publication


Date publication

avril 2017

Journal

Journal of the National Cancer Institute

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Pr BOUCHE Olivier, Dr FEIN Francine, Pr HEYD Bruno, Dr VERNEREY Dewi, Dr VIENOT Angélique, Dr LAKKIS Zaher, Mme MEURISSE Aurélia


Tous les auteurs :
Vienot A, Beinse G, Louvet C, de Mestier L, Meurisse A, Fein F, Heyd B, Cleau D, d'Engremont C, Dupont-Gossart AC, Lakkis Z, Tournigand C, Bouché O, Rousseau B, Neuzillet C, Bonnetain F, Borg C, Vernerey D

Résumé

In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning of L2 and to assess the benefit from chemotherapy among the identified risk groups.

Mots clés

Age Factors, Aged, Antineoplastic Combined Chemotherapy Protocols, therapeutic use, Ascites, etiology, Camptothecin, administration & dosage, Cancer Pain, etiology, Carcinoma, Pancreatic Ductal, drug therapy, Deoxycytidine, administration & dosage, Disease-Free Survival, Female, Fluorouracil, administration & dosage, Health Status, Humans, Irinotecan, Jaundice, etiology, Liver Neoplasms, secondary, Male, Middle Aged, Multivariate Analysis, Nomograms, Organoplatinum Compounds, administration & dosage, Oxaliplatin, Pancreatic Neoplasms, drug therapy, Proportional Hazards Models, Prospective Studies, Retreatment, Risk Factors, Smoking, Survival Rate

Référence

J. Natl. Cancer Inst.. 2017 Apr;: