Estimation of screening test (Hemoccult) sensitivity in colorectal cancer mass screening.
Fiche publication
Date publication
juin 2001
Journal
British journal of cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DANCOURT Vincent, Dr JOUVE Jean-Louis
Tous les auteurs :
Jouve JL, Remontet L, Dancourt V, Lejeune C, Benhamiche AM, Faivre J, Esteve J
Lien Pubmed
Résumé
3 controlled cohorts of mass-screening for colorectal cancer using a biennial faecal occult blood (HemoccultII test on well-defined European populations have demonstrated a 14% to 18% reduction in specific mortality. We aimed to estimate the sensitivity (S) of this HemoccultII test and and also mean sojourn time (MST) from French colorectal mass-screening programme data. 6 biennial screening rounds were performed from 1988 to 1998 in 45 603 individuals aged 45-74 years in Saône-et-Loire (Burgundy, France). The prevalent/incidence ratio was calculated in order to obtain a direct estimate of the product S.MST. The analysis of the proportional incidence and its modelling was used to derive an indirect estimate of S and MST. The product S.MST was higher for males than females and higher for left colon than either the right colon or rectum. The analysis of the proportional incidence confirmed the result for subsites but no other significant differences were found. The sensitivity was estimated at 0.57 and the MST at 2.56 years. This study confirms that the sensitivity of the Hemoccult test is relatively low and that the relatively short sojourn time is in favour of annual screening.
Mots clés
Aged, Colorectal Neoplasms, diagnosis, False Negative Reactions, Female, Humans, Incidence, Male, Mass Screening, Middle Aged, Models, Statistical, Occult Blood, Sensitivity and Specificity, Time Factors
Référence
Br. J. Cancer. 2001 Jun;84(11):1477-81