Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation.
Fiche publication
Date publication
août 2018
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HARLE Alexandre, Pr MERLIN Jean-Louis, Pr PEIFFERT Didier
Tous les auteurs :
Vogin G, Merlin JL, Rousseau A, Peiffert D, Harlé A, Husson M, Hajj LE, Levitchi M, Simon T, Simon JM
Lien Pubmed
Résumé
454 patients with prostate adenocarcinoma were accidentally overexposed to radiation in Epinal hospital, France, between August 1999 and January 2007. We aimed toevaluate whether radiation-induced CD4 or CD8 T-lymphocyte apoptosis (RILA) correlates with the severity of radiation toxicity.
Mots clés
Epinal adverse event, individual radiation sensitivity, late radiation-induced toxicity, prostate cancer, radiation-induced lymphocyte apoptosis
Référence
Oncotarget. 2018 Aug 24;9(66):32680-32689