CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest.

Fiche publication


Date publication

décembre 2012

Journal

British journal of pharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DEDIEU Stéphane, Pr MARTINY Laurent


Tous les auteurs :
Sick E, Jeanne A, Schneider C, Dedieu S, Takeda K, Martiny L

Résumé

CD47 is a ubiquitous 50 kDa five-spanning membrane receptor that belongs to the immunoglobulin superfamily. This receptor, also known as integrin-associated protein, mediates cell-to-cell communication by ligation to transmembrane signal-regulatory proteins SIRPα and SIRPγ and interacts with integrins. CD47 is also implicated in cell-extracellular matrix interactions via ligation with thrombospondins. Furthermore, CD47 is involved in many and diverse cellular processes, including apoptosis, proliferation, adhesion and migration. It also plays a key role in many immune and cardiovascular responses. Thus, this multifaceted receptor might be a central actor in the tumour microenvironment. Solid tumours are composed of not only cancer cells that actively proliferate but also other cell types including immune cells and fibroblasts that make up the tumour microenvironment. Tumour cell proliferation is strongly sustained by continuous sprouting of new vessels, which also represents a gate for metastasis. Moreover, infiltration of inflammatory cells is observed in most neoplasms. Much evidence has accumulated indicating that infiltrating leukocytes promote cancer progression. Given its ubiquitous expression on all the different cell types that compose the tumour microenvironment, targeting CD47 could represent an original therapeutic strategy in the field of oncology. We present a current overview of the biological effects associated with CD47 on cancer cells and stromal cells.

Mots clés

Animals, Antigens, CD47, physiology, Humans, Neoplasms, metabolism, Stromal Cells, physiology, Tumor Microenvironment, physiology

Référence

Br. J. Pharmacol.. 2012 Dec;167(7):1415-30