Switching Multivalent DNA Complexation using Metal-Controlled Cationic Supramolecular Self-Assemblies.
Fiche publication
Date publication
février 2018
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LEHN Jean-Marie
Tous les auteurs :
Drożdż W, Bessin Y, Gervais V, Cao XY, Lehn JM, Stefankiewicz AR, Ulrich S
Lien Pubmed
Résumé
We provide a proof-of-principle that coordination chemistry drives the in situ self-assembly of an inactive ligand into a multivalent cluster capable of effectively complexing DNA. We show that metal coordination and scavenging can be used to switch the multivalency of the system. Thus, controlled DNA complexation and decomplexation could be achieved.
Mots clés
Binding Sites, Cations, chemistry, Coordination Complexes, chemistry, DNA, chemistry, Hydrazones, chemistry, Ligands, Metals, chemistry, Molecular Structure, Thermodynamics
Référence
Chemistry. 2018 Feb 1;24(7):1518-1521