The role of irradiated heart and left ventricular volumes in heart failure occurrence after childhood cancer.
Fiche publication
Date publication
décembre 2018
Journal
European journal of heart failure
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MUNZER Martine
Tous les auteurs :
Mansouri I, Allodji RS, Hill C, El-Fayech C, Pein F, Diallo S, Schwartz B, Vu-Bezin G, Veres C, Souchard V, Dumas A, Bolle S, Thomas-Teinturier C, Pacquement H, Munzer M, Bondiau PY, Berchery D, Fresneau B, Oberlin O, Diallo I, De Vathaire F, Haddy N
Lien Pubmed
Résumé
Paediatric cancer survivors have a high risk of developing cardiac diseases, and the most frequent cardiac disease is heart failure (HF). The radiation dose-volume effects in the heart and cardiac substructures have not been explored in childhood cancer survivors (CCS). Therefore, the role of irradiated heart volume in the occurrence of HF among this population remains unclear. The aims of this study were to determine the doses and irradiated volumes of the heart and left ventricle (LV) related to the risk of HF in CCS and to investigate the impact of anthracycline exposure on this risk.
Mots clés
Dose response, Heart failure, Heart radiation dose, Left ventricle, Volume histograms
Référence
Eur. J. Heart Fail.. 2018 Dec 27;: