Development of a bioactive glass-polymer composite for wound healing applications.
Fiche publication
Date publication
juillet 2017
Journal
Materials science & engineering. C, Materials for biological applications
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Moura D, Souza MT, Liverani L, Rella G, Luz GM, Mano JF, Boccaccini AR
Lien Pubmed
Résumé
This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(ε-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with AgO and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0.25%, 0.5% and 0.75wt%). The composite membranes were characterized in terms of morphology, fiber diameter, weight loss, mineralization potential and mechanical performance.
Mots clés
Bioactive glass, Electrospinning, Mineralization, PCL, Wound healing
Référence
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:224-232