WntD and Diedel: Two immunomodulatory cytokines in Drosophila immunity.
Fiche publication
Date publication
octobre 2016
Journal
Fly
Auteurs
Membres identifiés du Cancéropôle Est :
Pr IMLER Jean-Luc, Dr MEIGNIN Carine
Tous les auteurs :
Lamiable O, Meignin C, Imler JL
Lien Pubmed
Résumé
Remarkable progress has been made on the understanding of the basic mechanisms of innate immunity in flies, from sensing infection to production of effector molecules. However, how the immune response is orchestrated at the level of the organism remains poorly understood. While cytokines activating immune responses, such as Spaetzle or Unpaired-3, have been identified and characterized in Drosophila, much less is known regarding immunosuppressor cytokines. In a recent publication, we reported the identification of a novel cytokine, Diedel, which acts as systemic negative regulator of the IMD pathway. Here, we discuss the similarities between Diedel and WntD, another immunomodulatory cytokine and present evidence that the 2 molecules act independently from one another.
Mots clés
Adaptor Proteins, Signal Transducing, metabolism, Animals, Antigens, Differentiation, metabolism, Cytokines, immunology, Drosophila Proteins, immunology, Drosophila melanogaster, immunology, Immunity, Innate, Intracellular Signaling Peptides and Proteins, immunology, Receptors, Immunologic, metabolism
Référence
Fly (Austin). 2016 10;10(4):187-94