Medulloblastomas associated with APC germline pathogenic variant share the good prognosis of CTNNB1 mutated medulloblastomas.

Fiche publication


Date publication

août 2019

Journal

Neuro-oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LACOUR Brigitte


Tous les auteurs :
Surun A, Varlet P, Brugières L, Lacour B, Faure-Conter C, Leblond P, Bertozzi-Salomon AI, Berger C, André N, Sariban E, Raimbault S, Prieur F, Desseigne F, Zattara H, Guimbaud R, Polivka M, Delisle MB, Vasiljevic A, Maurage CA, Figarella-Branger D, Coulet F, Guerrini-Rousseau L, Alapetite C, Dufour C, Colas C, Doz F, Bourdeaut F

Résumé

Medulloblastomas may occur in a predisposition context, including familial adenomatosis polyposis. Medulloblastomas related to APC germline pathogenic variant remain rare and poorly described. Their similarities with sporadic WNT medulloblastomas still require to be described.

Mots clés

APC, Familial Adenomatosis Polyposis, Gardner, WNT, medulloblastoma

Référence

Neuro-oncology. 2019 Aug 23;: