Quantitative background parenchymal enhancement to predict recurrence after neoadjuvant chemotherapy for breast cancer.

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Date publication

décembre 2019

Journal

Scientific reports

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole, Dr NOBLET Vincent


Tous les auteurs :
Moliere S, Oddou I, Noblet V, Veillon F, Mathelin C

Résumé

Breast background parenchymal enhancement (BPE) is an increasingly studied MRI parameter that reflects the microvasculature of normal breast tissue, which has been shown to change during neoadjuvant chemotherapy (NAC) for breast cancer. We aimed at evaluating the BPE in patients undergoing NAC and its prognostic value to predict recurrence. MRI BPE was visually and quantitatively evaluated before and after NAC in a retrospective cohort of 102 women with unilateral biopsy-proven invasive breast cancer. Pre-therapeutic BPE was not predictive of pathological response or recurrence. Quantitative post-therapeutic BPE was significantly decreased compared to pre-therapeutic value. Post-therapeutic quantitative BPE significantly predicted recurrence (HR = 6.38 (0.71, 12.06), p < 0.05).

Référence

Sci Rep. 2019 Dec 16;9(1):19185