In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact.
Fiche publication
Date publication
août 2015
Journal
BMC cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GROETZ Jean-Emmanuel
Tous les auteurs :
Hamdi DH, Barbieri S, Chevalier F, Groetz JE, Legendre F, Demoor M, Galera P, Lefaix JL, Saintigny Y
Lien Pubmed
Résumé
The benefit of better ballistic and higher efficiency of carbon ions for cancer treatment (hadron-therapy) is asserted since decades, especially for unresectable or resistant tumors like sarcomas. However, hadron-therapy with carbon ions stays underused and raises some concerns about potential side effects for patients. Chondrosarcoma is a cartilaginous tumor, chemo- and radiation-resistant, that lacks reference models for basic and pre-clinical studies in radiation-biology. Most studies about cellular effects of ionizing radiation, including hadrons, were performed under growth conditions dramatically different from human homeostasis. Tridimensional in vitro models are a fair alternative to animal models to approach tissue and tumors microenvironment.
Mots clés
Animals, Cell Culture Techniques, Cell Line, Tumor, Cell Proliferation, radiation effects, Cell Survival, radiation effects, Chondrosarcoma, pathology, DNA Repair, Histones, metabolism, Humans, In Vitro Techniques, Mice, Radiation Dosage, Radiation, Ionizing, Radiotherapy, methods
Référence
BMC Cancer. 2015 Aug 8;15:579