Evasion before invasion: Pre-cancer immunosurveillance.
Fiche publication
Date publication
avril 2021
Journal
Oncoimmunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MASCAUX Céline
Tous les auteurs :
Angelova M, Mascaux C, Galon J
Lien Pubmed
Résumé
Early intervention and risk stratification solutions for lung cancer are limited by our understanding of how carcinogenesis transforms the pre-invasive epithelium and its microenvironment before the carcinoma stage. We describe the sequence of molecular and cellular changes leading to cancer formation and the co-evolution of the earliest immune response. We revealed that immune sensing, infiltration and activation of immune cells, immune escape, and microenvironment reorganization occur early in pre-cancer. These findings urge the need for broadening the scope of the established immunotherapy approaches toward prophylactic cancer treatment and preventive intervention. Leveraging the immune contexture and the mechanisms of immune modulation for individuals at risk of developing cancer and further to the general population will allow for early detection, chemoprevention, and risk stratification in the near future.
Mots clés
Preinvasive, cancer prevention, carcinogenesis, immune contexture, immune response, immunoprevention, immunotherapy, lung squamous cell carcinoma, microenvironment, prophylactic
Référence
Oncoimmunology. 2021 Apr 25;10(1):1912250