Left Ventricular Transmural Gradient in Mitochondrial Respiration Is Associated with Increased Sub-Endocardium Nitric Oxide and Reactive Oxygen Species Productions.
Fiche publication
Date publication
janvier 2016
Journal
Frontiers in physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GENY Bernard
Tous les auteurs :
Kindo M, Gerelli S, Bouitbir J, Hoang Minh T, Charles AL, Mazzucotelli JP, Zoll J, Piquard F, Geny B
Lien Pubmed
Résumé
Left ventricle (LV) transmural gradient in mitochondrial respiration has been recently reported. However, to date, the physiological mechanisms involved in the lower endocardium mitochondrial respiration chain capacity still remain to be determined. Since, nitric oxide (NO) synthase expression in the heart has spatial heterogeneity and might impair mitochondrial function, we investigated a potential association between LV transmural NO and mitochondrial function gradient.
Mots clés
energetic gradient, heart, mitochondria, nitric oxide, oxidative stress, transmural
Référence
Front Physiol. 2016 ;7:331