Pan-cancer predictions of transcription factors mediating aberrant DNA methylation.
Fiche publication
Date publication
mars 2022
Journal
Epigenetics & chromatin
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARDET Anaïs, Dr WEBER Mickaël
Tous les auteurs :
Detilleux D, Spill YG, Balaramane D, Weber M, Bardet AF
Lien Pubmed
Résumé
Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently emerged as being able to shape DNA methylation patterns.
Mots clés
Bioinformatics, Cancer, DNA methylation, Transcription factors
Référence
Epigenetics Chromatin. 2022 Mar 24;15(1):10