Efficacy of haematopoietic stem cell boost as a rescue for poor graft function after haematopoietic stem cell transplantation: A multicentre retrospective study on behalf of the Francophone Society for Bone Marrow Transplantation and Cell Therapy (SFGM-TC
Fiche publication
Date publication
mars 2023
Journal
British journal of haematology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BILGER Karin, Pr RUBIO Marie Thérèse , Dr POCHON Cécile, Dr PAGLIUCA Simona
Tous les auteurs :
Gaffet M, Wiedemann A, Dalle JH, Bilger K, Forcade E, Robin M, Cornillon J, Labussière-Wallet H, Ceballos P, Bulabois CE, Loschi M, Orvain C, Rubio MT, Neven B, Pagliuca S, Pochon C
Lien Pubmed
Résumé
Haematopoietic stem cell reinjection may be a curative option for poor graft function after haematopoietic stem cell transplantation; however, literature supporting its use remains limited. We conducted a multicentre retrospective study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy, including 55 patients. We demonstrated response rates of nearly 40% and two-year survival of more than 60% in the context of an otherwise deadly complication and we observed that the timing of injection and the degree of cytopenia are strongly associated with outcomes. This study shows the feasibility of the procedure informing on its epidemiology, outcomes and prognostic factors, setting the stage for future guidelines.
Mots clés
allo-HSCT, boost, cytopenia, haematopoietic stem cell, poor graft function
Référence
Br J Haematol. 2023 03 27;: