Mu opioid receptor-positive neurons in the dorsal raphe nucleus are impaired by morphine abstinence.
Fiche publication
Date publication
juin 2023
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LUTZ Pierre-Eric, Dr DARCQ Emmanuel
Tous les auteurs :
Welsch L, Colantonio E, Falconnier C, Champagnol-DiLiberti C, Allain F, Ben Hamida S, Darcq E, Lutz PE, Kieffer BL
Lien Pubmed
Résumé
Chronic opioid exposure leads to hedonic deficits and enhanced vulnerability to addiction, which are observed and even strengthen after a period of abstinence, but the underlying circuit mechanisms are poorly understood. In this study, we test the hypothesis that neurons expressing mu opioid receptors (MORs) in the dorsal raphe nucleus (DRN) are involved in addiction vulnerability associated with morphine abstinence, using both molecular and behavioral approaches.
Mots clés
addiction-related behaviors, chronic morphine, mu opioid signaling, opto-intracranial self-stimulation, vTRAP-seq
Référence
Biol Psychiatry. 2023 06 29;: