Relationship between plasma tissue Factor Pathway Inhibitor (TFPI) levels, thrombin generation and clinical risk of bleeding in patients with severe haemophilia A or B.
Fiche publication
Date publication
avril 2024
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NGUYEN Philippe
Tous les auteurs :
Tardy-Poncet B, Montmartin A, Chambost H, Lienhart A, Frotscher B, Morange PE, Falaise C, Collange F, Dargaud Y, Toussaint-Hacquard M, Ardillon L, Wibaut B, Jeanpierre E, Nguyen P, Volot F, Tardy B
Lien Pubmed
Résumé
Bleeding severity in severe haemophilic patients, with low thrombin generation (TG) capacity, can vary widely between patients, possibly reflecting differences in tissue factor pathway inhibitor (TFPI) level.
Mots clés
severe haemophilia A, severe haemophilia B, thrombin generation and bleeding rate, tissue factor pathway inhibitor (TFPI)
Référence
Haemophilia. 2024 04 22;: