The use of supramolecular systems in biomedical applications for antimicrobial properties, biocompatibility, and drug delivery.
Fiche publication
Date publication
mai 2024
Journal
Biomedical materials (Bristol, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe
Tous les auteurs :
Li Y, Vrana NE, Letellier B, Lavalle P, Guilbaud-Chéreau C
Lien Pubmed
Résumé
Supramolecular chemistry is versatile for developing stimuli-responsive, dynamic and multifunctional structures. In the context of biomedical engineering applications, supramolecular assemblies are particularly useful as coatings for they can closely mimic the natural structure and organisation of the extracellular matrix (ECM), they can also fabricate other complex systems like drug delivery systems and bioinks. In the current context of growing medical device-associated complications and the developments in the controlled drug delivery and regenerative medicine fields,supramolecular assemblies are becoming an indispensable part of the biomedical engineering arsenal. This review covers the different supramolecular assemblies in different biomedical applications with a specific focus on antimicrobial coatings, coatings that enhance biocompatibility, surface modifications on implantable medical devices, systems that promote therapeutic efficiency in cancer therapy, and the development in bioinks. The introduced supramolecularsystems include multilayer coating by polyelectrolytes, polymers incorporated with nanoparticles, coating simulation of ECM, and drug delivery systems. A perspective on the application of supramolecular systems is also included.
Mots clés
antimicrobial, biocompatible, drug delivery, nanoparticles, polyelectrolyte coating, supramolecular coating
Référence
Biomed Mater. 2024 05 10;: