Natural polymers for the microencapsulation of cells.
Fiche publication
Date publication
novembre 2014
Journal
Journal of the Royal Society, Interface
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Gasperini L, Mano JF, Reis RL
Lien Pubmed
Résumé
The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an attractive procedure for many biomedical and biotechnological applications, such as xenotransplantation, maintenance of stem cell phenotype and bioprinting of three-dimensional scaffolds for tissue engineering and regenerative medicine. In this review, we focus on naturally derived polymers that can form hydrogels under mild conditions and that are thus capable of entrapping cells within controlled volumes. Our emphasis will be on polysaccharides and proteins, including agarose, alginate, carrageenan, chitosan, gellan gum, hyaluronic acid, collagen, elastin, gelatin, fibrin and silk fibroin. We also discuss the technologies commonly employed to encapsulate cells in these hydrogels, with particular attention on microencapsulation.
Mots clés
cell encapsulation, microencapsulation, natural polymers
Référence
J R Soc Interface. 2014 Nov 6;11(100):20140817