Pathophysiology of cutaneous T-cell lymphomas: Perspective from A French Referral Centre.
Fiche publication
Date publication
mai 2024
Journal
Immunology letters
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
Masson A, Lazaridou I, Moins-Teisserenc H, Ram-Wolff C, Giustiniani J, Bagot M, Battistella M, Bensussan A
Lien Pubmed
Résumé
Cutaneous T-cell lymphomas (CTCL) are a diverse group of malignant blood disorders characterized by initial skin infiltration, and sometimes, tumor spreading to lymph nodes, blood, and viscera. Mycosis fungoides is the most common form. Sézary syndrome is a distinctive form of CTCL marked by a significant presence of circulating tumor cells in peripheral blood. These diseases are characterized by the plasticity and heterogeneity of the tumor cells in the different tissue compartments, and a difficulty in identifying these tumor cells for diagnostic purposes and therapeutic monitoring. Progress has been made in the understanding of the pathophysiology of these diseases in recent years, and we provide here a review of these advancements.
Mots clés
CCR4, CCR8, KIR3DL2, Mycosis fungoides, Sézary syndrome, Tumor microenvironment ·
Référence
Immunol Lett. 2024 05 25;:106871