Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment.
Fiche publication
Date publication
mai 2024
Journal
Biochemistry. Biokhimiia
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEMIDOV Oleg
Tous les auteurs :
Pukhalskaia TV, Yurakova TR, Bogdanova DA, Demidov ON
Lien Pubmed
Résumé
Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and the most abundant population of immune cells infiltrating a tumor. TAMs can largely determine direction of anti-tumor immune response by promoting it or, conversely, contribute to formation of an immunosuppressive TME that allows tumors to evade immune control. Through interactions with tumor cells or other cells in the microenvironment and, as a result of action of anti-cancer therapy, macrophages can enter senescence. In this review, we have attempted to summarize information available in the literature on the role of senescent macrophages in tumors. With the recent development of senolytic therapeutic strategies aimed at removing senescent cells from an organism, it seems important to discuss functions of the senescent macrophages and potential role of the senolytic drugs in reprogramming TAMs to enhance anti-tumor immune response and improve efficacy of cancer treatment.
Mots clés
CD206, CXCR1, immunosuppression, p16INK4, p21cip1, senescent cells, tumor microenvironment
Référence
Biochemistry (Mosc). 2024 05;89(5):839-852