Temporal and spatial heterogeneity of HER2 status in metastatic colorectal cancer.
Fiche publication
Date publication
juin 2024
Journal
Diagnostic pathology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BORG Christophe, Mr MONNIEN Franck, Dr LAKKIS Zaher, Dr SELMANI Zohair, Pr BIBEAU Frédéric , Dr MOLIMARD Chloé
Tous les auteurs :
D'Angelo F, Monnien F, Overs A, Pem I, Dor F, Abad M, Felix S, Selmani Z, Lakkis Z, Borg C, Doussot A, Bibeau F, Molimard C
Lien Pubmed
Résumé
HER2-targeted therapies have recently emerged as an option in the management of metastatic colorectal cancer (mCRC) overexpressing HER2. However, data regarding HER2 status in primary CRC and its corresponding liver metastases are limited, potentially influencing clinical decisions. Therefore, the aim of this study was to compare the HER2 status in primary CRC and paired liver metastases.
Mots clés
Colorectal cancer, HER2, Liver metastasis, Tumor heterogeneity
Référence
Diagn Pathol. 2024 06 22;19(1):88