Concomitant decrease of E- and A-FABP expression predicts worse survival in urothelial bladder cancer patients.
Fiche publication
Date publication
juillet 2024
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LASCOMBE Isabelle, Mr MONNIEN Franck, Dr FAUCONNET Sylvie, Pr KLEINCLAUSS François
Tous les auteurs :
Saizonou I, Lascombe I, Monnien F, Bedgedjian I, Kleinclauss F, Algros MP, Fauconnet S
Lien Pubmed
Résumé
Non-muscle invasive bladder cancers (NMIBC) pTa-pT1 are depicted by a high risk of recurrence and/or progression with an unpredictable clinical evolution. Our aim was to identify, from the original resection specimen, tumors that will progress to better manage patients. We previously showed that A-FABP (Adipocyte- Fatty Acid Binding Protein) loss predicted NMIBC progression. Here we determined by immunohistochemistry the prognostic value of E-FABP (Epidermal-Fatty Acid Binding Protein) expression in 210 tumors (80 pTa, 75 pT1, 55 pT2-T4). Thus, E-FABP low expression was correlated with a high grade/stage, the presence of metastatic lymph nodes, and visceral metastases (p < 0.001). Unlike A-FABP in NMIBC, E-FABP low expression was not associated with RFS or PFS in Kaplan-Meier analysis. But patients of the overall cohort with a high E-FABP expression had a longer mOS (53.8 months vs. 29.3 months, p = 0.029). The immunohistochemical analysis on the same NMIBC tissue sections revealed that when A-FABP is absent, a high E-FABP expression is detected. E-FABP could compensate A-FABP loss. Interestingly, patients, whose original tumor presents both low E-FABP and negative A-FABP, had the worse survival, those maintaining the expression of both markers had better survival. To conclude, the combined evaluation of A- and E-FABP expression allowed to stratify patients with urothelial carcinoma for optimizing treatment and follow-up.
Mots clés
Humans, Urinary Bladder Neoplasms, pathology, Fatty Acid-Binding Proteins, metabolism, Male, Female, Aged, Prognosis, Middle Aged, Biomarkers, Tumor, metabolism, Aged, 80 and over, Kaplan-Meier Estimate, Immunohistochemistry
Référence
Sci Rep. 2024 07 4;14(1):15390