Biosourced Au(III) Complexes from D-Xylose: Synthesis and Biological Evaluation.
Fiche publication
Date publication
octobre 2024
Journal
ChemMedChem
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEVY Jérôme
Tous les auteurs :
Pascual LMH, Devy J, Colin M, Chazée L, Guillaneuf A, Marin B, Plantier-Royon R, Gatard S
Lien Pubmed
Résumé
A series of xylose-based ligands was obtained using a convenient approach, in a few steps from D-xylose. The complexation properties of these ligands towards Au3+ cations have been studied through different methods (multinuclear NMR, mass spectrometry, elemental analysis). The biological properties (antibacterial and anti-tumoral) of all the isolated xyloside Au(III) complexes were investigated in vitro. The xyloside Au(III) complexes gave the highest activities against E. coli(vs P. aeruginosa, S. aureus and S. epidermidis). The study also revealed that the nature of the sugar may play an important role in determining the selectivity of the antibacterial effect. Preliminary anti-tumoral evaluations showed that one complex containing a polyamine chain, exhibited interesting anti-proliferative activities on breast tumor cell lines MDA-MB-231 and BT-20. The anti-migratory effect of this complex also showed an average 35% reduction in cell migration on the same two cancer cell lines.
Mots clés
xylose * gold * complex * antitumor * antibacterial
Référence
ChemMedChem. 2024 10 21;:e202400565