Size and crystallinity effects on enzymatic activity and anti-inflammatory properties of cysteine-assisted Prussian blue nanozymes.
Fiche publication
Date publication
octobre 2024
Journal
Journal of colloid and interface science
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MENARD-MOYON Cécilia, Dr BIANCO Alberto
Tous les auteurs :
He Y, Bianco A, Ménard-Moyon C
Lien Pubmed
Résumé
Prussian blue nanoparticles (PB NPs) exhibit multiple enzymatic activities, such as superoxide dismutase-like, catalase-like, and peroxidase-like activities, which enable them to effectively scavenge reactive oxygen species (ROS) and demonstrate anti-inflammatory effects. To further enhance the enzymatic activity of PB NPs, it is crucial to explore the relationship between their physicochemical properties, such as size and crystallinity, and their enzymatic performance. In this study, PB NPs were synthesized using different pH levels and varying concentrations of cysteine (Cys) as a stabilizer. As the size decreases, crystallinity is gradually reduced, and defects increase. Cys-PB NPs with a smaller size and lower crystallinity exhibited high peroxidase-like activity, effectively reducing inflammation and scavenging intracellular ROS in vitro. Additionally, the stability of Cys-PB NPs plays a critical role in their anti-inflammatory properties, with higher stability favouring anti-inflammatory effect.
Mots clés
Biomedical, Catalase, Inorganic nanoparticles, Peroxidase, Reactive oxygen species, Scavenger, Superoxide dismutase
Référence
J Colloid Interface Sci. 2024 10 3;679(Pt A):930-938