Geoffroy M, Lemesle M, Kleinclauss A, Mazerbourg S, Batista L, Barberi-Heyob M, Bastogne T, Boireau W, Rouleau A, Dupommier D, Boisbrun M, Comoy C, Flament S, Grillier-Vuissoz I, Kuntz S

Int J Mol Sci. 2022 06 20;23(12):

New desulfured troglitazone derivatives: Improved synthesis and biological evaluation.

Dupommier D, Muller C, Comoy C, Mazerbourg S, Bordessa A, Piquard E, Pawlak M, Piquard F, Martin H, De Fays E, Grandemange S, Flament S, Boisbrun M

Eur J Med Chem. 2019 Dec 4;187:111939

Synthesis and evaluation of new designed multiple ligands directed towards both peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor.

Meyer M, Foulquier S, Dupuis F, Flament S, Grimaud L, Henrion D, Lartaud I, Monard G, Grillier-Vuissoz I, Boisbrun M

Eur J Med Chem. 2018 Aug 31;158:334-352

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells.

Berthe A, Zaffino M, Muller C, Foulquier F, Houdou M, Schulz C, Bost F, De Fay E, Mazerbourg S, Flament S

Breast Cancer Res. Treat.. 2018 Jul 3;:

Biotinylation enhances the anticancer effects of 15d‑PGJ2 against breast cancer cells.

Colin C, Meyer M, Cerella C, Kleinclauss A, Monard G, Boisbrun M, Diederich M, Flament S, Grillier-Vuissoz I, Kuntz S

Int. J. Oncol.. 2018 Mar 28;:

Pro-apoptotic effect of Δ2-TGZ in "claudin-1-low" triple-negative breast cancer cells: involvement of claudin-1.

Geoffroy M, Kleinclauss A, Grandemange S, Hupont S, Boisbrun M, Flament S, Grillier-Vuissoz I, Kuntz S

Breast Cancer Res. Treat.. 2017 Jul;:

Δ2-Troglitazone promotes cytostatic rather than pro-apoptotic effects in breast cancer cells cultured in high serum conditions.

Berthe A, Flament S, Grandemange S, Zaffino M, Boisbrun M, Mazerbourg S

Cell Cycle. 2016 Dec;15(24):3402-3412

Reprofiling of Troglitazone Towards More Active and Less Toxic Derivatives: A New Hope for Cancer Treatment?

Mazerbourg S, Kuntz S, Grillier-Vuissoz I, Berthe A, Geoffroy M, Flament S, Bordessa A, Boisbrun M

Curr Top Med Chem. 2016 ;16(19):2115-24

Sex Reversal in Amphibians.

Flament S

Sex Dev. 2016 ;10(5-6):267-278

PPARgamma-inactive Delta2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells.

Colin-Cassin C, Yao X, Cerella C, Chbicheb S, Kuntz S, Mazerbourg S, Boisbrun M, Chapleur Y, Diederich M, Flament S, Grillier-Vuissoz I

Mol Carcinog. 2015 May;54(5):393-404

From ERalpha66 to ERalpha36: a generic method for validating a prognosis marker of breast tumor progression.

Chamard-Jovenin C, Jung AC, Chesnel A, Abecassis J, Flament S, Ledrappier S, Macabre C, Boukhobza T, Dumond H

BMC Syst Biol. 2015 Jun 17;9(1):28

Energy restriction mimetic agents to target cancer cells: comparison between 2-deoxyglucose and thiazolidinediones.

Kuntz S, Mazerbourg S, Boisbrun M, Cerella C, Diederich M, Grillier-Vuissoz I, Flament S

Biochem Pharmacol. 2014 Nov 1;92(1):102-11

Optimization of troglitazone derivatives as potent anti-proliferative agents: towards more active and less toxic compounds.

Bordessa A, Colin-Cassin C, Grillier-Vuissoz I, Kuntz S, Mazerbourg S, Husson G, Vo M, Flament S, Martin H, Chapleur Y, Boisbrun M

Eur J Med Chem. 2014 Aug 18;83:129-40

Synthesis and Anti-Proliferative Activity of New Biphenyle-Benzylidenethiazolidine-2,4-dione Bis-Adducts Containing Various Heterocyclic Cores.

Meyer M, Kuntz S, Grillier-Vuissoz I, Martin H, Richert L, Flament S, Chapleur Y, Boisbrun M

Lett Drug Des Discov. 2014 Mar;11(3):256-64.

Mullerian inhibiting substance in the caudate amphibian Pleurodeles waltl.

Al-Asaad I, Chardard D, di Clemente N, Picard JY, Dumond H, Chesnel A, Flament S

Endocrinology. 2013 Oct;154(10):3931-6

An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism.

Ajj H, Chesnel A, Pinel S, Plenat F, Flament S, Dumond H

PLoS One. 2013 Apr 23;8(4):e61758

Synthesis of new troglitazone derivatives: anti-proliferative activity in breast cancer cell lines and preliminary toxicological study.

Salamone S, Colin C, Grillier-Vuissoz I, Kuntz S, Mazerbourg S, Flament S, Martin H, Richert L, Chapleur Y, Boisbrun M

Eur J Med Chem. 2012 May;51:206-15

Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERalpha36 induction.

Wallacides A, Chesnel A, Ajj H, Chillet M, Flament S, Dumond H

Mol Cell Endocrinol. 2012 Mar 5;350(1):61-71

Busulfan-mediated germ cell depletion does not alter gonad differentiation in the urodele amphibian Pleurodeles waltl.

Al-Asaad I, Dumond H, Chardard D, Chesnel A, Flament S

Sex Dev. 2012;6(4):188-200

EGR1 expression: a calcium and ERK1/2 mediated PPARgamma-independent event involved in the antiproliferative effect of 15-deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells.

Chbicheb S, Yao X, Rodeau JL, Salamone S, Boisbrun M, Thiel G, Spohn D, Grillier-Vuissoz I, Chapleur Y, Flament S, Mazerbourg S

Biochem Pharmacol. 2011 May 1;81(9):1087-97

Temporal and spatial SOX9 expression patterns in the course of gonad development of the caudate amphibian Pleurodeles waltl.

Dumond H, Al-Asaad I, Chesnel A, Chardard D, Boizet-Bonhoure B, Flament S, Kuntz S

J Exp Zool B Mol Dev Evol. 2011 May 15;316B(3):199-211

New troglitazone derivatives devoid of PPARgamma agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines.

Colin C, Salamone S, Grillier-Vuissoz I, Boisbrun M, Kuntz S, Lecomte J, Chapleur Y, Flament S

Breast Cancer Res Treat. 2010 Nov;124(1):101-10

Evidence for a conserved role of retinoic acid in urodele amphibian meiosis onset.

Wallacides A, Chesnel A, Chardard D, Flament S, Dumond H

Dev Dyn. 2009 Jun;238(6):1389-98.

Crosstalk between adenosine receptor (A(2A) isoform) and ER alpha mediates ethanol action in MCF-7 breast cancer cells

Etique N, Grillier-Vuissoz I, Lecomte J, Flament S

Oncol Rep. 2009 Apr;21(4):977-81.

Lifelong testicular differentiation in Pleurodeles waltl (Amphibia, Caudata).

Flament S, Dumond H, Chardard D, Chesnel A

Reprod Biol Endocrinol. 2009 Mar 5;7:21.

Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines.

Lecomte J, Flament S, Salamone S, Boisbrun M, Mazerbourg S, Chapleur Y, Grillier-Vuissoz I

Breast Cancer Res Treat. 2008 Dec;112(3):437-51

Female-enriched expression of ERalpha during gonad differentiation of the urodele amphibian Pleurodeles waltl.

Ko CI, Chesnel A, Mazerbourg S, Kuntz S, Flament S, Chardard D

Gen Comp Endocrinol. 2008 Apr 1;156(2):234-45

Freemartin in the amphibian Pleurodeles waltl: parabiosis between individuals from opposite sex triggers both germ and somatic cells alterations during female gonad development.

Dumond H, Maufroid JP, Ko CI, Chardard D, Chesnel A, Flament S

Mol Reprod Dev. 2008 Mar;75(3):439-49.

Sexual development of the urodele amphibian Pleurodeles waltl.

Dumond H, Kuntz S, Chesnel A, Ko CI, Wallacides A, Chardard D, Flament S

Sex Dev. 2008;2(2):104-14

Ethanol-induced ligand-independent activation of ER alpha mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells

Etique N, Flament S, Lecomte J, Grillier-Vuissoz I

Int J Oncol. 2007 Dec;31(6):1509-18.

Intracellular acidification delays hormonal G2/M transition and inhibits G2/M transition triggered by thiophosphorylated MAPK in Xenopus oocytes.

Sellier C, Bodart JF, Flament S, Baert F, Gannon J, Vilain JP

J Cell Biochem. 2006 May 15;98(2):287-300.

Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF-7 human breast cancer cells.

Etique N, Grillier-Vuissoz I, Flament S

Oncol Rep. 2006 Mar;15(3):603-8.

Differential roles of p39Mos-Xp42Mpk1 cascade proteins on Raf1 phosphorylation and spindle morphogenesis in Xenopus oocytes.

Bodart JF, Baert FY, Sellier C, Duesbery NS, Flament S, Vilain JP

Dev Biol. 2005 Jul 15;283(2):373-83.

Differential expression of P450 aromatase during gonadal sex differentiation and sex reversal of the newt Pleurodeles waltl.

Kuntz S, Chesnel A, Duterque-Coquillaud M, Grillier-Vuissoz I, Callier M, Dournon C, Flament S, Chardard D

J. Steroid Biochem. Mol. Biol.. 2003 Jan;84(1):89-100

Steroids, aromatase and sex differentiation of the newt Pleurodeles waltl.

Kuntz S, Chardard D, Chesnel A, Grillier-Vuissoz I, Flament S

Cytogenet Genome Res. 2003;101(3-4):283-8.

Xkid chromokinesin is required for the meiosis I to meiosis II transition in Xenopus laevis oocytes.

Perez LH, Antonio C, Flament S, Vernos I, Nebreda AR

Nat Cell Biol. 2002 Oct;4(10):737-42.

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