Mme THIBAULT-CARPENTIER Christelle

Fiche personne

Coordonnées

IGBMC
1 rue Laurent Fries
BP 10142
67404 ILLKIRCH

03 88 65 34 26

thibault@igbmc.fr

Territoire

Alsace

Affiliation

IGBMC - Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)

Équipes/plateformes

GenomEast

Projets

Analyse par transcriptomique spatiale du dynamisme du paysage immunitaire dans le microenvironnement de carcinomes épidermoïdes de la tête et du cou chez des patients bénéficiant d’une immunothérapie (ImmuneSpace)

2023 - Porteur du projet : Dr JUNG Alain - Partenaire : Pr CHENARD Marie-Pierre , Dr MARTIN Sophie , Mme THIBAULT-CARPENTIER Christelle , Dr BURGY Mickaël

Publications

TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma.

Helleux A, Davidson G, Lallement A, Hourani FA, Haller A, Michel I, Fadloun A, Thibault-Carpentier C, Su X, Lindner V, Tricard T, Lang H, Tannir NM, Davidson I, Malouf GG

EMBO Mol Med. 2025 03 27;:

p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironment.

Yanushko D, German Falcon B, El Bizri R, Pervizou D, Dolgos R, Keime C, Ye T, Thibault-Carpentier C, Le Magnen C, Henri S, Laverny G, Metzger D

Cell Death Dis. 2025 01 26;16(1):46

Mesenchymal-like tumor cells and myofibroblastic cancer-associated fibroblasts are associated with progression and immunotherapy response of clear-cell renal cell carcinoma.

Davidson G, Helleux A, Vano YA, Lindner V, Fattori A, Cerciat M, Elaidi RT, Verkarre V, Sun CM, Chevreau C, Bennamoun M, Lang H, Tricard T, Fridman WH, Sautes-Fridman C, Su X, Plassard D, Keime C, Thibault-Carpentier C, Barthélémy P, Oudard SM, Davidson I, Malouf GG

Cancer Res. 2023 06 19;:

Nivolumab, nivolumab-ipilimumab, and VEGFR-tyrosine kinase inhibitors as first-line treatment for metastatic clear-cell renal cell carcinoma (BIONIKK): a biomarker-driven, open-label, non-comparative, randomised, phase 2 trial.

Vano YA, Elaidi R, Bennamoun M, Chevreau C, Borchiellini D, Pannier D, Maillet D, Gross-Goupil M, Tournigand C, Laguerre B, Barthélémy P, Coquan E, Gravis G, Houede N, Cancel M, Huillard O, Beuzeboc P, Fournier L, Méjean A, Cathelineau X, Doumerc N, Paparel P, Bernhard JC, de la Taille A, Bensalah K, Tricard T, Waeckel T, Pignot G, Braychenko E, Caruso S, Sun CM, Verkarre V, Lacroix G, Moreira M, Meylan M, Bougouïn A, Phan L, Thibault-Carpentier C, Zucman-Rossi J, Fridman WH, Sautès-Fridman C, Oudard S

Lancet Oncol. 2022 Apr 4;:

Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.

Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S

J Exp Med. 2021 Oct 4;218(10):

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma.

Rabé M, Dumont S, Álvarez-Arenas A, Janati H, Belmonte-Beitia J, Calvo GF, Thibault-Carpentier C, Séry Q, Chauvin C, Joalland N, Briand F, Blandin S, Scotet E, Pecqueur C, Clairambault J, Oliver L, Perez-Garcia V, Nadaradjane A, Cartron PF, Gratas C, Vallette FM

Cell Death Dis. 2020 Jan 6;11(1):19

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production.

Piccand J, Vagne C, Blot F, Meunier A, Beucher A, Strasser P, Lund ML, Ghimire S, Nivlet L, Lapp C, Petersen N, Engelstoft MS, Thibault-Carpentier C, Keime C, Correa SJ, Schreiber V, Molina N, Schwartz TW, De Arcangelis A, Gradwohl G

Mol Metab. 2019 Nov;29:24-39

Responses to climatic and pathogen threats differ in biodynamic and conventional vines.

Soustre-Gacougnolle I, Lollier M, Schmitt C, Perrin M, Buvens E, Lallemand JF, Mermet M, Henaux M, Thibault-Carpentier C, Dembelé D, Steyer D, Clayeux C, Moneyron A, Masson JE

Sci Rep. 2018 Nov 15;8(1):16857

MITF-high and MITF-low cells and a novel subpopulation expressing genes of both cell states contribute to intra and inter-tumoral heterogeneity of primary melanoma.

Ennen M, Keime C, Gambi G, Kieny A, Coassolo S, Thibault-Carpentier C, Margerin-Schaller F, Davidson G, Vagne C, Lipsker D, Davidson I

Clin. Cancer Res.. 2017 Aug;:

The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate.

Martinot E, Sèdes L, Baptissart M, Holota H, Rouaisnel B, Damon-Soubeyrand C, De Haze A, Saru JP, Thibault-Carpentier C, Keime C, Lobaccaro JA, Baron S, Benoit G, Caira F, Beaudoin C, Volle DH

Stem Cell Reports. 2017 Jul 11;9(1):315-328

Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.

Freyermuth F, Rau F, Kokunai Y, Linke T, Sellier C, Nakamori M, Kino Y, Arandel L, Jollet A, Thibault C, Philipps M, Vicaire S, Jost B, Udd B, Day JW, Duboc D, Wahbi K, Matsumura T, Fujimura H, Mochizuki H, Deryckere F, Kimura T, Nukina N, Ishiura S, Lacroix V, Campan-Fournier A, Navratil V, Chautard E, Auboeuf D, Horie M, Imoto K, Lee KY, Swanson MS, Lopez de Munain A, Inada S, Itoh H, Nakazawa K, Ashihara T, Wang E, Zimmer T, Furling D, Takahashi MP, Charlet-Berguerand N

Nat Commun. 2016 Apr;7:11067

The tumor suppressor Ikaros shapes the repertoire of notch target genes in T cells.

Geimer Le Lay AS, Oravecz A, Mastio J, Jung C, Marchal P, Ebel C, Dembele D, Jost B, Le Gras S, Thibault C, Borggrefe T, Kastner P, Chan S

Sci Signal. 2014 Mar 18;7(317):ra28

Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.

Koutsopoulos OS, Kretz C, Weller CM, Roux A, Mojzisova H, Bohm J, Koch C, Toussaint A, Heckel E, Stemkens D, Ter Horst SA, Thibault C, Koch M, Mehdi SQ, Bijlsma EK, Mandel JL, Vermot J, Laporte J

Eur J Hum Genet. 2013 Jun;21(6):637-42

Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in fragile X-associated tremor/ataxia syndrome.

Sellier C, Freyermuth F, Tabet R, Tran T, He F, Ruffenach F, Alunni V, Moine H, Thibault C, Page A, Tassone F, Willemsen R, Disney MD, Hagerman PJ, Todd PK, Charlet-Berguerand N

Cell Rep. 2013 Mar 28;3(3):869-80

Transcriptome Analysis for Notch3 Target Genes Identifies Grip2 as a Novel Regulator of Myogenic Response in the Cerebrovasculature.

Fouillade C, Baron-Menguy C, Domenga-Denier V, Thibault C, Takamiya K, Huganir R, Joutel A

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):76-86

Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.

Franco-Montoya ML, Boucherat O, Thibault C, Chailley-Heu B, Incitti R, Delacourt C, Bourbon JR

Physiol Genomics. 2011 Nov 7;43(21):1226-40

Tripartite motif 24 (Trim24/Tif1alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Raralpha) inhibition

Tisserand J, Khetchoumian K, Thibault C, Dembele D, Chambon P, Losson R

J Biol Chem. 2011 Sep 23;286(38):33369-79

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Fugier C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de Munain AL, Sergeant N, Laquerriere A, Thibault C, Deryckere F, Auboeuf D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I, Bassez G, Laporte J, Furling D, Charlet-Berguerand N

Nat Med. 2011 Jun;17(6):720-5

SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas.

Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembele D, Martinet N, Thibault C, Huelsken J, Brambilla E, du Manoir S

PLoS One. 2010 Jan 29;5(1):e8960.

Transcriptome analysis identifies genes with enriched expression in the mouse central extended amygdala.

Becker JA, Befort K, Blad C, Filliol D, Ghate A, Dembele D, Thibault C, Koch M, Muller J, Lardenois A, Poch O, Kieffer BL

Neuroscience. 2008 Oct 28;156(4):950-65

Bcl2, a transcriptional target of p38alpha, is critical for neuronal commitment of mouse embryonic stem cells.

Trouillas M, Saucourt C, Duval D, Gauthereau X, Thibault C, Dembele D, Feraud O, Menager J, Rallu M, Pradier L, Boeuf H

Cell Death Differ. 2008 Sep;15(9):1450-9

Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala.

Befort K, Filliol D, Ghate A, Darcq E, Matifas A, Muller J, Lardenois A, Thibault C, Dembele D, Le Merrer J, Becker JA, Poch O, Kieffer BL

Eur J Neurosci. 2008 Jun;27(11):2973-84.

Transcriptome analysis of bull semen with extreme nonreturn rate: use of suppression-subtractive hybridization to identify functional markers for fertility.

Lalancette C, Thibault C, Bachand I, Caron N, Bissonnette N

Biol Reprod. 2008 Apr;78(4):618-35

Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor.

Befort K, Filliol D, Darcq E, Ghate A, Matifas A, Lardenois A, Muller J, Thibault C, Dembele D, Poch O, Kieffer BL

Ann N Y Acad Sci. 2008;1129:175-84.

Gene expression profiling in lung fibroblasts reveals new players in alveolarization.

Boucherat O, Franco-Montoya ML, Thibault C, Incitti R, Chailley-Heu B, Delacourt C, Bourbon JR

Physiol Genomics. 2007 Dec 19;32(1):128-41

Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.

Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M, Zucman-Rossi J, Cammas F, Lerouge T, Thibault C, Metzger D, Chambon P, Losson R

Nat. Genet.. 2007 Dec;39(12):1500-6

Transcriptomic analysis of the sulfate starvation response of Pseudomonas aeruginosa.

Tralau T, Vuilleumier S, Thibault C, Campbell BJ, Hart CA, Kertesz MA

J Bacteriol. 2007 Oct;189(19):6743-50

Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes.

Rodius S, Indra G, Thibault C, Pfister V, Georges-Labouesse E

J Cell Physiol. 2007 Aug;212(2):439-49.

Pitfalls of homozygosity mapping: an extended consanguineous Bardet-Biedl syndrome family with two mutant genes (BBS2, BBS10), three mutations, but no triallelism.

Laurier V, Stoetzel C, Muller J, Thibault C, Corbani S, Jalkh N, Salem N, Chouery E, Poch O, Licaire S, Danse JM, Amati-Bonneau P, Bonneau D, Megarbane A, Mandel JL, Dollfus H

Eur J Hum Genet. 2006 Nov;14(11):1195-203