Montserrat-Gomez M, Gogl G, Carrasco K, Betzi S, Durbesson F, Cousido-Siah A, Kostmann C, Essig DJ, Strømgaard K, Østergaard S, Morelli X, Trave G, Vincentelli R, Bailly E, Borg JP

Biochim Biophys Acta Proteins Proteom. 2023 12 22;:140989

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family.

Zambo B, Gogl G, Morlet B, Eberling P, Negroni L, Moine H, Travé G

FEBS J. 2023 11 9;:

The Human PDZome 2.0: Characterization of a New Resource to Test for PDZ Interactions by Yeast Two-Hybrid.

Castro-Cruz M, Lembo F, Borg JP, Travé G, Vincentelli R, Zimmermann P

Membranes (Basel). 2023 08 17;13(8):

Evidence for direct interaction between the oncogenic proteins E6 and E7 of high-risk Human Papillomavirus (HPV).

Lim J, Lilie H, Kalbacher H, Roos N, Frecot DI, Feige M, Conrady M, Votteler T, Cousido-Siah A, Bartoli GC, Iftner T, Trave G, Simon C

J Biol Chem. 2023 06 22;:104954

ProFeatMap: a highly customizable tool for 2D feature representation of protein sets.

Bich G, Monsellier E, Travé G, Nominé Y

Bioinform Adv. 2023 03 9;3(1):vbad022

Native holdup (nHU) to measure binding affinities from cell extracts.

Zambo B, Morlet B, Negroni L, Trave G, Gogl G

Sci Adv. 2022 12 21;8(51):eade3828

The Cooperative Folding of Annexin A2 Relies on a Transient Non-Native Intermediate.

Hollås H, Ramirez J, Nominé Y, Kostmann C, Toto A, Gianni S, Travé G, Vedeler A

Biophys J. 2022 11 1;:

Quantitative fragmentomics allow affinity mapping of interactomes.

Gogl G, Zambo B, Kostmann C, Cousido-Siah A, Morlet B, Durbesson F, Negroni L, Eberling P, Jané P, Nominé Y, Zeke A, Østergaard S, Monsellier É, Vincentelli R, Travé G

Nat Commun. 2022 09 17;13(1):5472

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.

Poirson J, Suarez IP, Straub ML, Cousido-Siah A, Peixoto P, Hervouet E, Foster A, Mitschler A, Mukobo N, Chebaro Y, Garcin D, Recberlik S, Gaiddon C, Altschuh D, Nominé Y, Podjarny A, Trave G, Masson M

J Virol. 2022 Apr 27;:e0187521

Promiscuity mapping of the S100 protein family using a high-throughput holdup assay.

Simon MA, Bartus É, Mag B, Boros E, Roszjár L, Gógl G, Travé G, Martinek TA, Nyitray L

Sci Rep. 2022 Apr 7;12(1):5904

A scalable strategy to solve structures of PDZ domains and their complexes.

Cousido-Siah A, Carneiro L, Kostmann C, Ecsedi P, Nyitray L, Trave G, Gogl G

Acta Crystallogr D Struct Biol. 2022 Apr 1;78(Pt 4):509-516

Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.

Gogl G, Tugaeva KV, Eberling P, Kostmann C, Trave G, Sluchanko NN

Nat Commun. 2021 03 15;12(1):1677

A Computational Protocol to Analyze PDZ/PBM Affinity Data Obtained by High-Throughput Holdup Assay.

Jané P, Chiron L, Bich G, Travé G, Nominé Y

Methods Mol Biol. 2021 ;2256:61-74

Conformational editing of intrinsically disordered protein by α-methylation.

Bauer V, Schmidtgall B, Gógl G, Dolenc J, Osz J, Nominé Y, Kostmann C, Cousido-Siah A, Mitschler A, Rochel N, Travé G, Kieffer B, Torbeev V

Chem Sci. 2020 Nov 4;12(3):1080-1089

Structure of high-risk papillomavirus type 31 E6 oncogenic protein and characterization of E6/E6AP/p53 complex formation.

Conrady MC, Suarez I, Gogl G, Frecot DI, Bonhoure A, Kostmann C, Cousido-Siah A, Mitschler A, Lim J, Masson M, Iftner T, Stubenrauch F, Trave G, Simon C

J Virol. 2020 Oct 28;:

Benchtop holdup assay for quantitative affinity-based analysis of sequence determinants of protein-motif interactions.

Bonhoure A, Forster A, Babah KO, Gógl G, Eberling P, Kostmann C, Volkmer R, Mancilla VT, Travé G, Nominé Y

Anal. Biochem.. 2020 May 16;:113772

Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.

Gogl G, Jane P, Caillet-Saguy C, Kostmann C, Bich G, Cousido-Siah A, Nyitray L, Vincentelli R, Wolff N, Nomine Y, Sluchanko NN, Trave G

Structure. 2020 Apr 6;:

Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase.

Jané P, Gógl G, Kostmann C, Bich G, Girault V, Caillet-Saguy C, Eberling P, Vincentelli R, Wolff N, Travé G, Nominé Y

PLoS One. 2020 ;15(12):e0244613

A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth.

Celegato M, Messa L, Goracci L, Mercorelli B, Bertagnin C, Spyrakis F, Suarez I, Cousido-Siah A, Travé G, Banks L, Cruciani G, Palù G, Loregian A

Cancer Lett.. 2019 Nov 3;:

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

Gógl G, Biri-Kovács B, Durbesson F, Jane P, Nomine Y, Kostmann C, Bilics V, Simon M, Reményi A, Vincentelli R, Trave G, Nyitray L

J. Mol. Biol.. 2019 Feb 3;:

High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay.

Duhoo Y, Girault V, Turchetto J, Ramond L, Durbesson F, Fourquet P, Nominé Y, Cardoso V, Sequeira AF, Brás JLA, Fontes CMGA, Travé G, Wolff N, Vincentelli R

Methods Mol. Biol.. 2019 ;2025:439-476

One-step affinity purification of fusion proteins with optimal monodispersity and biological activity: application to aggregation-prone HPV E6 proteins.

Bonhoure A, Demenge A, Kostmann C, San José L, De la Cal E, Armisen P, Nominé Y, Travé G

Microb. Cell Fact.. 2018 Dec 1;17(1):191

Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β.

Ainouze M, Rochefort P, Parroche P, Roblot G, Tout I, Briat F, Zannetti C, Marotel M, Goutagny N, Auron P, Traverse-Glehen A, Lunel-Potencier A, Golfier F, Masson M, Robitaille A, Tommasino M, Carreira C, Walzer T, Henry T, Zanier K, Trave G, Hasan UA

PLoS Pathog.. 2018 Aug 8;14(8):e1007158

Structural Insights in Multifunctional Papillomavirus Oncoproteins.

Suarez I, Trave G

Viruses. 2018 01 15;10(1):

Mapping the interactome of HPV E6 and E7 oncoproteins with the Ubiquitin-Proteasome System.

Poirson J, Biquand E, Straub ML, Cassonnet P, Nominé Y, Jones L, van der Werf S, Travé G, Zanier K, Jacob Y, Demeret C, Masson M

FEBS J.. 2017 Aug;:

HPV-mediated inactivation of tumor suppressor p53.

Travé G, Zanier K

Cell Cycle. 2016 Sep;15(17):2231-2

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.

Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, Travé G, Zanier K

Nature. 2016 Jan;529(7587):541-5

Artificial microRNAs against the viral E6 protein provoke apoptosis in HPV positive cancer cells.

Bonetta AC, Mailly L, Robinet E, Trave G, Masson M, Deryckere F

Biochem Biophys Res Commun. 2015 Aug 1. pii: S0006-291X(15)30375-2

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

Vincentelli R, Luck K, Poirson J, Polanowska J, Abdat J, Blemont M, Turchetto J, Iv F, Ricquier K, Straub ML, Forster A, Cassonnet P, Borg JP, Jacob Y, Masson M, Nomine Y, Reboul J, Wolff N, Charbonnier S, Trave G

Nat Methods. 2015 Aug;12(8):787-93

Spot peptide arrays and SPR measurements: throughput and quantification in antibody selectivity studies.

Vernet T, Choulier L, Nomine Y, Bellard L, Baltzinger M, Trave G, Altschuh D

J Mol Recognit. 2015 May 11

Targeting the Two Oncogenic Functional Sites of the HPV E6 Oncoprotein with a High-Affinity Bivalent Ligand.

Ramirez J, Poirson J, Foltz C, Chebaro Y, Schrapp M, Meyer A, Bonetta A, Forster A, Jacob Y, Masson M, Deryckere F, Trave G

Angew Chem Int Ed Engl. 2015 May 27

Disorder-to-order transition of MAGI-1 PDZ1 C-terminal extension upon peptide binding: thermodynamic and dynamic insights.

Ramirez J, Recht R, Charbonnier S, Ennifar E, Atkinson RA, Trave G, Nomine Y, Kieffer B

Biochemistry. 2015 Feb 17;54(6):1327-37

Antibody Binding Selectivity: Alternative Sets of Antigen Residues Entail High-Affinity Recognition.

Nominé Y, Choulier L, Travé G, Vernet T, Altschuh D

PLoS ONE. 2015 ;10(12):e0143374

Design of a PDZbody, a bivalent binder of the E6 protein from human papillomavirus.

Karlsson OA, Ramirez J, Oberg D, Malmqvist T, Engstrom A, Friberg M, Chi CN, Widersten M, Trave G, Nilsson MT, Jemth P

Sci Rep. 2015 Mar 23;5:9382

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides.

Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, Trave G, Lohrey C, Hoppe-Seyler K, Hoppe-Seyler F

PLoS One. 2015 Jul 7;10(7):e0132339

Effect of serine phosphorylation and Ser25 phospho-mimicking mutations on nuclear localisation and ligand interactions of annexin A2.

Grindheim AK, Hollas H, Ramirez J, Saraste J, Trave G, Vedeler A

J Mol Biol. 2014 Jun 26;426(13):2486-99

Production and characterization of a retinoic acid receptor RARgamma construction encompassing the DNA binding domain and the disordered N-terminal proline rich domain.

Martinez-Zapien D, Delsuc MA, Trave G, Lutzing R, Rochette-Egly C, Kieffer B

Protein Expr Purif. 2014 Mar;95:113-20

An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein.

Belyaeva TA, Nicol C, Cesur O, Trave G, Blair GE, Stonehouse NJ

Cancers (Basel). 2014 Jul 24;6(3):1553-69

The E6AP binding pocket of the HPV16 E6 oncoprotein provides a docking site for a small inhibitory peptide unrelated to E6AP, indicating druggability of E6.

Zanier K, Stutz C, Kintscher S, Reinz E, Sehr P, Bulkescher J, Hoppe-Seyler K, Trave G, Hoppe-Seyler F

PLoS One. 2014 Nov 10;9(11):e112514

Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, Poussin-Courmontagne P, Cura V, Brimer N, Babah KO, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Trave G

Science. 2013 Feb 8;339(6120):694-8

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.

Neveu G, Cassonnet P, Vidalain PO, Rolloy C, Mendoza J, Jones L, Tangy F, Muller M, Demeret C, Tafforeau L, Lotteau V, Rabourdin-Combe C, Trave G, Dricot A, Hill DE, Vidal M, Favre M, Jacob Y

Methods. 2012 Dec;58(4):349-59

Thermal stability of chicken brain alpha-spectrin repeat 17: a spectroscopic study.

Brenner AK, Kieffer B, Trave G, Froystein NA, Raae AJ

J Biomol NMR. 2012 Jun;53(2):71-83

Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53.

Zanier K, ould M'hamed ould Sidi A, Boulade-Ladame C, Rybin V, Chappelle A, Atkinson A, Kieffer B, Trave G

Structure. 2012 Apr 4;20(4):604-17

Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6.

Sidi AO, Babah KO, Brimer N, Nomine Y, Romier C, Kieffer B, Pol SV, Trave G, Zanier K

Protein Expr Purif. 2011 Nov;80(1):8-16

PDZ-peptide complexes: as exciting as ever.

Trave G

Structure. 2011 Oct 12;19(10):1350-1.

Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1.

Fournane S, Charbonnier S, Chapelle A, Kieffer B, Orfanoudakis G, Trave G, Masson M, Nomine Y

J Mol Recognit. 2011 Jul-Aug;24(4):511-23

Phage display can select over-hydrophobic sequences that may impair prediction of natural domain-peptide interactions.

Luck K, Trave G

Bioinformatics. 2011 Apr 1;27(7):899-902

How viruses hijack cell regulation.

Davey NE, Trave G, Gibson TJ

Trends Biochem Sci. 2011 Mar;36(3):159-69

The structural and dynamic response of MAGI-1 PDZ1 with noncanonical domain boundaries to the binding of human papillomavirus E6.

Charbonnier S, Nomine Y, Ramirez J, Luck K, Chapelle A, Stote RH, Trave G, Kieffer B, Atkinson RA

J Mol Biol. 2011 Mar 11;406(5):745-63

Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain.

Bernard X, Robinson P, Nomine Y, Masson M, Charbonnier S, Ramirez-Ramos JR, Deryckere F, Trave G, Orfanoudakis G

PLoS One. 2011;6(10):e25981

Putting into practice domain-linear motif interaction predictions for exploration of protein networks.

Luck K, Fournane S, Kieffer B, Masson M, Nomine Y, Trave G

PLoS One. 2011;6(11):e25376

E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo.

Zanier K, Ruhlmann C, Melin F, Masson M, Ould M'hamed Ould Sidi A, Bernard X, Fischer B, Brino L, Ristriani T, Rybin V, Baltzinger M, Vande Pol S, Hellwig P, Schultz P, Trave G

J Mol Biol. 2010 Feb 12;396(1):90-104

Prevalence of intrinsic disorder in the hepatitis C virus ARFP/Core+1/S protein.

Boumlic A, Nomine Y, Charbonnier S, Dalagiorgou G, Vassilaki N, Kieffer B, Trave G, Mavromara P, Orfanoudakis G

FEBS J. 2010 Feb;277(3):774-89

Degradation of p53 by human Alphapapillomavirus E6 proteins shows a stronger correlation with phylogeny than oncogenicity.

Fu L, Van Doorslaer K, Chen Z, Ristriani T, Masson M, Trave G, Burk RD

PLoS One. 2010 Sep 17;5(9). pii: e12816.

ELM: the status of the 2010 eukaryotic linear motif resource.

Gould CM, Diella F, Via A, Puntervoll P, Gemund C, Chabanis-Davidson S, Michael S, Sayadi A, Bryne JC, Chica C, Seiler M, Davey NE, Haslam N, Weatheritt RJ, Budd A, Hughes T, Pas J, Rychlewski L, Trave G, Aasland R, Helmer-Citterich M, Linding R, Gibson TJ

Nucleic Acids Res. 2010 Jan;38(Database issue):D167-80

Identification of unusual E6 and E7 proteins within avian papillomaviruses: cellular localization, biophysical characterization, and phylogenetic analysis.

Van Doorslaer K, Sidi AO, Zanier K, Rybin V, Deryckere F, Rector A, Burk RD, Lienau EK, van Ranst M, Trave G

J Virol. 2009 Sep;83(17):8759-70

A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells.

Ristriani T, Fournane S, Orfanoudakis G, Trave G, Masson M

Oncogene. 2009 Feb 5;28(5):762-72

Defining the minimal interacting regions of the tight junction protein MAGI-1 and HPV16 E6 oncoprotein for solution structure studies.

Charbonnier S, Stier G, Orfanoudakis G, Kieffer B, Atkinson RA, Trave G

Protein Expr Purif. 2008 Jul;60(1):64-73

Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation.

Michael S, Trave G, Ramu C, Chica C, Gibson TJ

Bioinformatics. 2008 Feb 15;24(4):453-7

Understanding eukaryotic linear motifs and their role in cell signaling and regulation.

Diella F, Haslam N, Chica C, Budd A, Michael S, Brown NP, Trave G, Gibson TJ

Front Biosci. 2008 May 1;13:6580-603.

The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV.

Aukrust I, Hollas H, Strand E, Evensen L, Trave G, Flatmark T, Vedeler A

J Mol Biol. 2007 May 18;368(5):1367-78

Formation of well-defined soluble aggregates upon fusion to MBP is a generic property of E6 proteins from various human papillomavirus species.

Zanier K, Nomine Y, Charbonnier S, Ruhlmann C, Schultz P, Schweizer J, Trave G

Protein Expr Purif. 2007 Jan;51(1):59-70

Engineering, biophysical characterisation and binding properties of a soluble mutant form of annexin A2 domain IV that adopts a partially folded conformation.

Aukrust I, Evensen L, Hollas H, Berven F, Atkinson RA, Trave G, Flatmark T, Vedeler A

J Mol Biol. 2006 Oct 20;363(2):469-81

NMR in the SPINE Structural Proteomics project.

Ab E, Atkinson AR, Banci L, Bertini I, Ciofi-Baffoni S, Brunner K, Diercks T, Dotsch V, Engelke F, Folkers GE, Griesinger C, Gronwald W, Gunther U, Habeck M, de Jong RN, Kalbitzer HR, Kieffer B, Leeflang BR, Loss S, Luchinat C, Marquardsen T, Moskau D, Neidig KP, Nilges M, Piccioli M, Pierattelli R, Rieping W, Schippmann T, Schwalbe H, Trave G, Trenner J, Wohnert J, Zweckstetter M, Kaptein R

Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1150-61

Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis.

Nomine Y, Masson M, Charbonnier S, Zanier K, Ristriani T, Deryckere F, Sibler AP, Desplancq D, Atkinson RA, Weiss E, Orfanoudakis G, Kieffer B, Trave G

Mol Cell. 2006 Mar 3;21(5):665-78.