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Recherche
Mots clés : Bioinformatique,Génomique,Facteurs de transcription,Méthylation de l'ADN
Thématique de recherche :
Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors (TFs) to regulatory elements through the recognition of specific DNA sequence motifs. Additionally, the physical access of TFs to DNA can be modulated by epigenetic regulation, such as DNA methylation, nucleosome positioning and histone modifications. Failure to maintain this tight regulation of gene expression results in developmental defects and various diseases including cancer. We use both computational and experimental approaches and integrate genomic data to study TF binding and its regulation in cellular systems.
Projets
Identification des facteurs de transcriptions conduisant à une méthylation abberante de l'ADN dans les cellules cancéreuses
2017 - Porteur du projet : Dr BARDET Anaïs
Publications
MethyLasso: a segmentation approach to analyze DNA methylation patterns and identify differentially methylated regions from whole-genome datasets.
Balaramane D, Spill YG, Weber M, Bardet AF
Nucleic Acids Res. 2024 10 18;:
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma.
Sundaramoorthy S, Colombo DF, Sanalkumar R, Broye L, Balmas Bourloud K, Boulay G, Cironi L, Stamenkovic I, Renella R, Kuttler F, Turcatti G, Rivera MN, Mühlethaler-Mottet A, Bardet AF, Riggi N
JCI Insight. 2024 07 22;9(14):
Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells.
Al Adhami H, Vallet J, Schaal C, Schumacher P, Bardet AF, Dumas M, Chicher J, Hammann P, Daujat S, Weber M
Nucleic Acids Res. 2023 02 11;:
