Pr ROUX Stéphane

Fiche personne

Coordonnées

Institut UTINAM - UMR CNRS 6213
UFR des Sciences et Techniques
16 route de Gray
25030 BESANCON Cedex

03 81 66 62 99

Territoire

Franche-Comté

Statut

Enseignant-Chercheur

Affiliation

Institut UTINAM (Univers, Temps-fréquence, Interfaces, Nanostructures, Atmosphère et environnement, Molécules) (UTINAM)

Équipes/plateformes

Equipe UMR 6213 - Equipe "Nanoparticules, Contaminants, Membranes"

Projets

Nanostructures à base d’or pour la radiothérapie interne (IRRO)

2024 - Porteur du projet : Pr ROUX Stéphane - Partenaire : Pr DENAT Franck , Dr COLLIN Bertrand

Nanoparticules multimodales excitables par rayons X, de la conception à la validation préclinique (e-NanoRX)

2016 - Porteur du projet : Dr PINEL Sophie - Partenaire : Pr BARBERI-HEYOB Muriel , Pr BASTOGNE Thierry , Dr DEVY Jérôme , Dr FROCHOT Céline , Pr ROUX Stéphane

Nanohybrides à base de nanotubes de titanates et de nanoparticules d'or pour la radiosensibilisation de tumeurs prostatiques (NanoRadioPro)

2015 - Porteur du projet : Pr MILLOT Nadine - Partenaire : Dr MIRJOLET Céline , Pr ROUX Stéphane

Publications

Increase of OH radical yields due to the decomposition of hydrogen peroxide by gold nanoparticles under X-ray irradiation.

Okazaki Y, Kusumoto T, Roux S, Hirayama R, Fromm M, Bazzi R, Kodaira S, Kataoka J

RSC Adv. 2024 03 20;14(14):9509-9513

Quantitative, precise and multi-wavelength evaluation of the light-to-heat conversion efficiency for nanoparticular photothermal agents with calibrated photoacoustic spectroscopy.

Lucas T, Linger C, Naillon T, Hashemkhani M, Abiven L, Viana B, Chaneac C, Laurent G, Bazzi R, Roux S, Becharef S, Avveduto G, Gazeau F, Gateau J

Nanoscale. 2023 10 17;:

Evaluation of Radiosensitization and Cytokine Modulation by Differentially PEGylated Gold Nanoparticles in Glioblastoma Cells.

Kerr BN, Duffy D, McInerney CE, Hutchinson A, Dabaja I, Bazzi R, Roux S, Prise KM, Butterworth KT

Int J Mol Sci. 2023 06 12;24(12):

Radiosensitization with Gadolinium Chelate-Coated Gold Nanoparticles Prevents Aggressiveness and Invasiveness in Glioblastoma.

Durand M, Chateau A, Jubréaux J, Devy J, Paquot H, Laurent G, Bazzi R, Roux S, Richet N, Reinhard-Ruch A, Chastagner P, Pinel S

Int J Nanomedicine. 2023 01 13;18:243-261

Quantitative Comparison of the Light-to-Heat Conversion Efficiency in Nanomaterials Suitable for Photothermal Therapy.

Paściak A, Marin R, Abiven L, Pilch-Wróbel A, Misiak M, Xu W, Prorok K, Bezkrovnyi O, Marciniak Ł, Chanéac C, Gazeau F, Bazzi R, Roux S, Viana B, Lehto VP, Jaque D, Bednarkiewicz A

ACS Appl Mater Interfaces. 2022 07 18;:

Two step promotion of a hot tumor immune environment by gold decorated iron oxide nanoflowers and light-triggered mild hyperthermia.

Nicolas-Boluda A, Laurent G, Bazzi R, Roux S, Donnadieu E, Gazeau F

Nanoscale. 2021 Nov 9;:

Characterization and biodistribution of Au nanoparticles loaded in PLGA nanocarriers using an original encapsulation process.

Laurent G, Benbalit C, Chrétien C, Dupuis C, Pellequer Y, Bazzi R, Thakare VS, Denat F, Roux S, Béduneau A

Colloids Surf B Biointerfaces. 2021 May 23;205:111875

The detrimental invasiveness of glioma cells controlled by gadolinium chelate-coated gold nanoparticles.

Durand M, Lelievre E, Chateau A, Berquand A, Laurent G, Carl P, Roux S, Chazee L, Bazzi R, Eghiaian F, Jubreaux J, Ronde P, Barberi-Heyob M, Chastagner P, Devy J, Pinel S

Nanoscale. 2021 May 12;:

A Proof-of-Concept Study on the Therapeutic Potential of Au Nanoparticles Radiolabeled with the Alpha-Emitter Actinium-225.

Salvanou EA, Stellas D, Tsoukalas C, Mavroidi B, Paravatou-Petsotas M, Kalogeropoulos N, Xanthopoulos S, Denat F, Laurent G, Bazzi R, Roux S, Bouziotis P

Pharmaceutics. 2020 Feb 21;12(2):

Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors.

Loiseau A, Boudon J, Oudot A, Moreau M, Boidot R, Chassagnon R, Saïd NM, Roux S, Mirjolet C, Millot N

Cancers (Basel). 2019 Dec 6;11(12):

Uptake and excretion dynamics of gold nanoparticles in cancer cells and fibroblasts.

Ivosev V, Jimenez-Sanchez G, Porcel E, Yang X, González Vargas CR, Abi Haidar D, Bazzi R, Stefancikova L, Roux S, Lacombe S

Nanotechnology. 2019 Nov 29;:

Quality control of gold nanoparticles as pharmaceutical ingredients.

Pallotta A, Boudier A, Creusot B, Brun E, Sicard-Roselli C, Bazzi R, Roux S, Clarot I

Int J Pharm. 2019 Oct 5;569:118583

Fluorescent Radiosensitizing Gold Nanoparticles.

Jiménez Sánchez G, Maury P, Stefancikova L, Campion O, Laurent G, Chateau A, Bouraleh Hoch F, Boschetti F, Denat F, Pinel S, Devy J, Porcel E, Lacombe S, Bazzi R, Roux S

Int J Mol Sci. 2019 Sep 18;20(18):

Ultrasmall theranostic gadolinium-based nanoparticles improve high-grade rat glioma survival.

Dufort S, Appelboom G, Verry C, Barbier EL, Lux F, Bräuer-Krisch E, Sancey L, Chang SD, Zhang M, Roux S, Tillement O, Le Duc G

J Clin Neurosci. 2019 Sep;67:215-219

Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging.

Thakare V, Tran VL, Natuzzi M, Thomas E, Moreau M, Romieu A, Collin B, Courteau A, Vrigneaud JM, Louis C, Roux S, Boschetti F, Tillement O, Lux F, Denat F

RSC Adv. 2019 Aug 8;9(43):24811-24815

Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy.

Pagáčová E, Štefančíková L, Schmidt-Kaler F, Hildenbrand G, Vičar T, Depeš D, Lee JH, Bestvater F, Lacombe S, Porcel E, Roux S, Wenz F, Kopečná O, Falková I, Hausmann M, Falk M

Int J Mol Sci. 2019 Jan 30;20(3):

The contribution of hydrogen peroxide to the radiosensitizing effect of gold nanoparticles.

Khalil TT, Bazzi R, Roux S, Fromm M

Colloids Surf B Biointerfaces. 2018 Dec 17;175:606-613

AGuIX from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.

Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P, Barberi-Heyob M, Frochot C, Verry C, Balosso J, Evans M, Sidi-Boumedine J, Janier M, Butterworth K, McMahon S, Prise K, Aloy MT, Ardail D, Rodriguez-Lafrasse C, Porcel E, Lacombe S, Berbeco R, Allouch A, Perfettini JL, Chargari C, Deutsch E, Le Duc G, Tillement O

Br J Radiol. 2018 Sep 18;:20180365

One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles.

Tran VL, Thakare V, Rossetti F, Baudouin A, Ramniceanu G, Doan BT, Mignet N, Comby-Zerbino C, Antoine R, Dugourd P, Boschetti F, Denat F, Louis C, Roux S, Doussineau T, Tillement O, Lux F

J Mater Chem B. 2018 Aug 7;6(29):4821-4834

Granulocyte Colony-Stimulating Factor Nanocarriers for Stimulation of the Immune System (Part I): Synthesis and Biodistribution Studies.

De Crozals G, Kryza D, Sánchez GJ, Roux S, Mathé D, Taleb J, Dumontet C, Janier M, Chaix C

Bioconjug. Chem.. 2018 Mar 21;29(3):795-803

Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/Cu PET Imaging.

Tran VL, Thakare V, Natuzzi M, Moreau M, Oudot A, Vrigneaud JM, Courteau A, Louis C, Roux S, Boschetti F, Denat F, Tillement O, Lux F

Contrast Media Mol Imaging. 2018 ;2018:7938267

Preclinical evaluation of gold-DTDTPA nanoparticles as theranostic agents in prostate cancer radiotherapy.

Butterworth KT, Nicol JR, Ghita M, Rosa S, Chaudhary P, McGarry CK, McCarthy HO, Jimenez-Sanchez G, Bazzi R, Roux S, Tillement O, Coulter JA, Prise KM

Nanomedicine (Lond). 2016 08;11(16):2035-47

The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors.

Dufort S, Le Duc G, Salomé M, Bentivegna V, Sancey L, Bräuer-Krisch E, Requardt H, Lux F, Coll JL, Perriat P, Roux S, Tillement O

Sci Rep. 2016 07 14;6:29678

Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization.

Laurent G, Bernhard C, Dufort S, Jiménez Sánchez G, Bazzi R, Boschetti F, Moreau M, Vu TH, Collin B, Oudot A, Herath N, Requardt H, Laurent S, Vander Elst L, Muller R, Dutreix M, Meyer M, Brunotte F, Perriat P, Lux F, Tillement O, Le Duc G, Denat F, Roux S

Nanoscale. 2016 Jun;8(23):12054-65

Enhanced chemiluminescence-based detection on gold substrate after electrografting of diazonium precursor-coated gold nanoparticles.

Houmed Adabo A, Zeggari R, Mohamed Saïd N, Bazzi R, Elie-Caille C, Marquette C, Martini M, Tillement O, Perriat P, Chaix C, Boireau W, Roux S

J Colloid Interface Sci. 2016 Apr;467:271-9

Initial in vitro and in vivo assessment of Au@DTDTPA-RGD nanoparticles for Gd-MRI and 68Ga-PET dual modality imaging.

Tsoukalas C, Laurent G, Jiménez Sánchez G, Tsotakos T, Bazzi R, Stellas D, Anagnostopoulos C, Moulopoulos L, Koutoulidis V, Paravatou-Petsotas M, Xanthopoulos S, Roux S, Bouziotis P

EJNMMI Phys. 2015 Dec;2(Suppl 1):A89

Gadolinium-based nanoparticles for theranostic MRI-radiosensitization.

Lux F, Sancey L, Bianchi A, Crémillieux Y, Roux S, Tillement O

Nanomedicine (Lond). 2015 ;10(11):1801-15

The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy.

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Cremillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O

Br J Radiol. 2014 Sep;87(1041):20140134

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