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Front Immunol. 2024 08 7;15:1437961

Using immunogenic cell death to improve anticancer efficacy of immune checkpoint inhibitors: From basic science to clinical application.

Ghiringhelli F, Rébé C

Immunol Rev. 2023 08 18;:

Associating immunotherapy and targeted therapies: facts and hopes.

Ladoire S, Rébé C, Ghiringhelli F

Clin Cancer Res. 2022 11 29;:

Tumor Immunogenic Cell Death as a Mediator of Intratumor CD8 T-Cell Recruitment.

Roussot N, Ghiringhelli F, Rébé C

Cells. 2022 11 18;11(22):

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors.

Kieu TL, Pierre L, Derangère V, Perrey S, Truntzer C, Jalil A, Causse S, Groetz E, Dumont A, Guyard L, Arnould L, de Barros JP, Apetoh L, Rébé C, Limagne E, Jourdan T, Demizieux L, Masson D, Thomas C, Ghiringhelli F, Rialland M

Cell Death Dis. 2022 09 2;13(9):758

Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses.

Bruchard M, Geindreau M, Perrichet A, Truntzer C, Ballot E, Boidot R, Racoeur C, Barsac E, Chalmin F, Hibos C, Baranek T, Paget C, Ryffel B, Rébé C, Paul C, Végran F, Ghiringhelli F

Nat Immunol. 2022 Feb;23(2):262-274

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells.

Limagne E, Nuttin L, Thibaudin M, Jacquin E, Aucagne R, Bon M, Revy S, Barnestein R, Ballot E, Truntzer C, Derangère V, Fumet JD, Latour C, Rébé C, Bellaye PS, Kaderbhaï CG, Spill A, Collin B, Callanan MB, Lagrange A, Favier L, Coudert B, Arnould L, Ladoire S, Routy B, Joubert P, Ghiringhelli F

Cancer Cell. 2022 Jan 17;:

Follicular helper-T cells restore CD8-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy.

Niogret J, Berger H, Rebe C, Mary R, Ballot E, Truntzer C, Thibaudin M, Derangère V, Hibos C, Hampe L, Rageot D, Accogli T, Joubert P, Routy B, Harker J, Vegran F, Ghiringhelli F, Chalmin F

J Immunother Cancer. 2021 Jun;9(6):

Can the hyperthermia-mediated Heat Shock Factor (HSF) /Heat Shock Protein (HSP) 70 pathway dampen the cytokine storm during SARS-CoV-2 infection?

Rébé C, Ghiringhelli F, Garrido C

Br J Pharmacol. 2020 Dec 11;:

Understanding Inflammasomes and PD-1/PD-L1 Crosstalk to Improve Cancer Treatment Efficiency.

Perrichet A, Ghiringhelli F, Rébé C

Cancers (Basel). 2020 Nov 27;12(12):

Angiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockers.

Medjebar S, Truntzer C, Perrichet A, Limagne E, Fumet JD, Richard C, Elkrief A, Routy B, Rébé C, Ghiringhelli F

Oncoimmunology. 2020 Oct 27;9(1):1836766

Ndiaye M, Rébé C, Pilot T, Ilie A, Ghiringhelli F

Rev. Neurol. (Paris). 2020 Sep;176S:S45

Interleukin-1β and Cancer.

Rébé C, Ghiringhelli F

Cancers (Basel). 2020 Jul 4;12(7):

Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages.

Ménégaut L, Thomas C, Jalil A, Julla JB, Magnani C, Ceroi A, Basmaciyan L, Dumont A, Le Goff W, Mathew MJ, Rébé C, Dérangère V, Laubriet A, Crespy V, Pais de Barros JP, Steinmetz E, Venteclef N, Saas P, Lagrost L, Masson D

Cell Rep. 2020 May 19;31(7):107665

Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.

Pilot T, Fratti A, Thinselin C, Perrichet A, Demontoux L, Limagne E, Derangère V, Ilie A, Ndiaye M, Jacquin E, Garrido C, Ghiringhelli F, Chalmin F, Rébé C

J Immunother Cancer. 2020 May;8(1):

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction.

Chevriaux A, Pilot T, Derangère V, Simonin H, Martine P, Chalmin F, Ghiringhelli F, Rébé C

Front Cell Dev Biol. 2020 ;8:167

Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study.

Chanteloup G, Cordonnier M, Isambert N, Bertaut A, Hervieu A, Hennequin A, Luu M, Zanetta S, Coudert B, Bengrine L, Desmoulins I, Favier L, Lagrange A, Pages PB, Gutierrez I, Lherminier J, Avoscan L, Jankowski C, Rébé C, Chevriaux A, Padeano MM, Coutant C, Ladoire S, Causeret S, Arnould L, Charon-Barra C, Cottet V, Blanc J, Binquet C, Bardou M, Garrido C, Gobbo J

J Extracell Vesicles. 2020 ;9(1):1766192

Platinum Derivatives Effects on Anticancer Immune Response.

Rébé C, Demontoux L, Pilot T, Ghiringhelli F

Biomolecules. 2019 Dec 20;10(1):

Heat Shock Proteins and Inflammasomes.

Martine P, Rébé C

Int J Mol Sci. 2019 Sep 12;20(18):

STAT3, a Master Regulator of Anti-Tumor Immune Response.

Rébé C, Ghiringhelli F

Cancers (Basel). 2019 Aug 30;11(9):

Hypotonic stress enhances colon cancer cell death induced by platinum derivatives and immunologically improves anti-tumor efficacy of intraperitoneal chemotherapy.

Demontoux L, Derangère V, Pilot T, Thinselin C, Chevriaux A, Chalmin F, Bouyer F, Ghiringhelli F, Rébé C

Int. J. Cancer. 2019 Jul 25;:

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment.

Dumont A, de Rosny C, Kieu TL, Perrey S, Berger H, Fluckiger A, Muller T, Pais de Barros JP, Pichon L, Hichami A, Thomas C, Rébé C, Ghiringhelli F, Rialland M

Cell Death Dis. 2019 Jun 19;10(7):485

Anti-MEK and Anti-EGFR mAbs in RAS-Mutant Metastatic Colorectal Cancer: Case Series and Rationale.

Ledys F, Derangère V, Réda M, Guion JF, Milliex R, Roux V, Limagne E, Arnould L, Bengrine L, Ghiringhelli F, Rébé C

Adv Ther. 2019 Apr 12;:

HSP70 is a negative regulator of NLRP3 inflammasome activation.

Martine P, Chevriaux A, Derangère V, Apetoh L, Garrido C, Ghiringhelli F, Rébé C

Cell Death Dis. 2019 Mar 15;10(4):256

Correction: Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Khan NA, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(4):e0176574

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway.

Zeriouh W, Nani A, Belarbi M, Dumont A, de Rosny C, Aboura I, Ghanemi FZ, Murtaza B, Patoli D, Thomas C, Apetoh L, Rébé C, Delmas D, Akhtar Khan N, Ghiringhelli F, Rialland M, Hichami A

PLoS ONE. 2017 ;12(2):e0170823

Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα.

Fluckiger A, Dumont A, Derangère V, Rébé C, de Rosny C, Causse S, Thomas C, Apetoh L, Hichami A, Ghiringhelli F, Rialland M

Oncogene. 2016 Sep;35(35):4611-22

Liver X receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRbeta subcellular localization.

Courtaut F, Derangere V, Chevriaux A, Ladoire S, Cotte AK, Arnould L, Boidot R, Rialland M, Ghiringhelli F, Rebe C

Oncotarget. 2015 Sep 29;6(29):26651-62

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

Bruchard M, Rebe C, Derangere V, Togbe D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Vegran F, Ghiringhelli F

Nat Immunol. 2015 Aug;16(8):859-70

Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells.

Derangere V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, Causse SZ, Limagne E, Vegran F, Ladoire S, Simon B, Boireau W, Hichami A, Apetoh L, Mignot G, Ghiringhelli F, Rebe C

Cell Death Differ. 2014 Dec;21(12):1914-24

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.

Vegran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, Chalmin F, Rebe C, Derangere V, Ryffel B, Kato M, Prevost-Blondel A, Ghiringhelli F, Apetoh L

Nat Immunol. 2014 Aug;15(8):758-66

SOCS3 transactivation by PPARgamma prevents IL-17-driven cancer growth.

Berger H, Vegran F, Chikh M, Gilardi F, Ladoire S, Bugaut H, Mignot G, Chalmin F, Bruchard M, Derangere V, Chevriaux A, Rebe C, Ryffel B, Pot C, Hichami A, Desvergne B, Ghiringhelli F, Apetoh L

Cancer Res. 2013 Jun 15;73(12):3578-90

Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth.

Hervieu A, Rébé C, Végran F, Chalmin F, Bruchard M, Vabres P, Apetoh L, Ghiringhelli F, Mignot G

J. Invest. Dermatol.. 2013 Feb;133(2):499-508

Bleomycin exerts ambivalent antitumor immune effect by triggering both immunogenic cell death and proliferation of regulatory T cells.

Bugaut H, Bruchard M, Berger H, Derangère V, Odoul L, Euvrard R, Ladoire S, Chalmin F, Végran F, Rébé C, Apetoh L, Ghiringhelli F, Mignot G

PLoS ONE. 2013 ;8(6):e65181

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.

Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Végran F, Boireau W, Simon B, Ryffel B, Connat JL, Kanellopoulos J, Martin F, Rébé C, Apetoh L, Ghiringhelli F

Nat. Med.. 2013 Jan;19(1):57-64

Immunomodulation and anti-inflammatory roles of polyphenols as anticancer agents.

Ghiringhelli F, Rebe C, Hichami A, Delmas D

Anticancer Agents Med Chem. 2012 Oct 1;12(8):852-73.

Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression.

Chalmin F, Mignot G, Bruchard M, Chevriaux A, Vegran F, Hichami A, Ladoire S, Derangere V, Vincent J, Masson D, Robson SC, Eberl G, Pallandre JR, Borg C, Ryffel B, Apetoh L, Rebe C, Ghiringhelli F

Immunity. 2012 Mar 23;36(3):362-73

Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape.

Ghiringhelli F, Bruchard M, Chalmin F, Rebe C

J Biomed Biotechnol. 2012;2012:473712

Tumor exosome-mediated MDSC activation.

Mignot G, Chalmin F, Ladoire S, Rebe C, Ghiringhelli F

Am J Pathol. 2011 Mar;178(3):1403-4; author reply 1404-5.

Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy.

Ladoire S, Arnould L, Mignot G, Coudert B, Rebe C, Chalmin F, Vincent J, Bruchard M, Chauffert B, Martin F, Fumoleau P, Ghiringhelli F

Breast Cancer Res Treat. 2011 Jan;125(1):65-72

5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity.

Vincent J, Mignot G, Chalmin F, Ladoire S, Bruchard M, Chevriaux A, Martin F, Apetoh L, Rebe C, Ghiringhelli F

Cancer Res. 2010 Apr 15;70(8):3052-61

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, Boireau W, Rouleau A, Simon B, Lanneau D, De Thonel A, Multhoff G, Hamman A, Martin F, Chauffert B, Solary E, Zitvogel L, Garrido C, Ryffel B, Borg C, Apetoh L, Rebe C, Ghiringhelli F

J Clin Invest. 2010 Feb 1;120(2):457-71