Scekic-Zahirovic J, Benetton C, Brunet A, Ye X, Logunov E, Douchamps V, Megat S, Andry V, Kan VWY, Stuart-Lopez G, Gilet J, Guillot SJ, Dirrig-Grosch S, Gorin C, Trombini M, Dieterle S, Sinniger J, Fischer M, René F, Gunes Z, Kessler P, Dupuis L, Pradat PF, Goumon Y, Goutagny R, Marchand-Pauvert V, Liebscher S, Rouaux C

Sci Transl Med. 2024 03 13;16(738):eadg3665

Impact of Neurons on Patient-Derived Cardiomyocytes Using Organ-On-A-Chip and iPSC Biotechnologies.

Bernardin AA, Colombani S, Rousselot A, Andry V, Goumon Y, Delanoë-Ayari H, Pasqualin C, Brugg B, Jacotot ED, Pasquié JL, Lacampagne A, Meli AC

Cells. 2022 11 25;11(23):

Assessment of plasma Catestatin in COVID-19 reveals a hitherto unknown inflammatory activity with impact on morbidity-mortality.

Schneider F, Le Borgne P, Herbrecht JE, Danion F, Solis M, Hellé S, Betscha C, Clere-Jehl R, Lefebvre F, Castelain V, Goumon Y, Metz-Boutigue MH

Front Immunol. 2022 09 29;13:985472

Functional brain-wide network mapping during acute stress exposure in rats: Interaction between the lateral habenula and cortical, amygdalar, hypothalamic and monoaminergic regions.

Durieux L, Herbeaux K, Borcuk C, Hildenbrand C, Andry V, Goumon Y, Barbelivien A, Mathis C, Bataglia D, Majchrzak M, Lecourtier L

Eur J Neurosci. 2022 08 22;:

Hippocampal Cannabinoid 1 Receptors Are Modulated Following Cocaine Self-administration in Male Rats.

De Sa Nogueira D, Bourdy R, Alcala-Vida R, Filliol D, Andry V, Goumon Y, Zwiller J, Romieu P, Merienne K, Olmstead MC, Befort K

Mol Neurobiol. 2022 Jan 15;:

Central metabolism as a potential origin of sex differences in morphine antinociception but not in the induction of antinociceptive tolerance in mice.

Gabel F, Hovhannisyan V, Andry V, Goumon Y

Br J Pharmacol. 2022 Jan 5;:

Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells.

Streit L, Moog S, Hugel S, Rame M, Tanguy E, Andry V, Schmid HA, Brunaud L, Bihain F, Nominé-Criqui C, Goumon Y, Lacomme S, Lomazzi S, Vix M, Mutter D, Vitale N, Ory S, Gasman S

Cancer Lett. 2021 Oct 9;:

Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system.

de Sa Nogueira D, Bourdy R, Filliol D, Awad G, Andry V, Goumon Y, Olmstead MC, Befort K

Appetite. 2021 09 1;164:105258

The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach.

Bourdy R, Hertz A, Filliol D, Andry V, Goumon Y, Mendoza J, Olmstead MC, Befort K

Eur J Nutr. 2021 Jun 24;:

Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice.

Letellier B, Kremer M, Becker LJ, Andry V, Goumon Y, Leboulleux Q, Hener P, Inquimbert P, Couqueberg N, Waltisperger E, Yalcin I, Mouthon F, Droguerre M, Charvériat M, Barrot M

Pain. 2021 Mar 24;:

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.

Wahis J, Baudon A, Althammer F, Kerspern D, Goyon S, Hagiwara D, Lefevre A, Barteczko L, Boury-Jamot B, Bellanger B, Abatis M, Da Silva Gouveia M, Benusiglio D, Eliava M, Rozov A, Weinsanto I, Knobloch-Bollmann HS, Kirchner MK, Roy RK, Wang H, Pertin M, Inquimbert P, Pitzer C, Siemens J, Goumon Y, Boutrel B, Lamy CM, Decosterd I, Chatton JY, Rouach N, Young WS, Stern JE, Poisbeau P, Stoop R, Darbon P, Grinevich V, Charlet A

Nat Neurosci. 2021 Feb 15;:

Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain.

Kamoun N, Gazzo G, Goumon Y, Andry V, Yalcin I, Poisbeau P

Neuropharmacology. 2020 Nov 16;182:108407

Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis.

Carmon O, Laguerre F, Riachy L, Delestre-Delacour C, Wang Q, Tanguy E, Jeandel L, Cartier D, Thahouly T, Haeberlé AM, Fouillen L, Rezazgui O, Schapman D, Haefelé A, Goumon Y, Galas L, Renard PY, Alexandre S, Vitale N, Anouar Y, Montero-Hadjadje M

FASEB J.. 2020 Mar 29;:

A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain.

Hilfiger L, Zhao Q, Kerspern D, Inquimbert P, Andry V, Goumon Y, Darbon P, Hibert M, Charlet A

Sci Rep. 2020 Feb 20;10(1):3017

Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice .

Gabel F, Aubry AS, Hovhannisyan V, Chavant V, Weinsanto I, Maduna T, Darbon P, Goumon Y

Front Oncol. 2020 ;10:25

A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System.

Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel JM, Hurlemann R, Herpertz SC, Pitzer C, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A, Grinevich V

Neuron. 2019 May 13;:

Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation.

Melchior M, Juif PE, Gazzo G, Petit-Demoulière N, Chavant V, Lacaud A, Goumon Y, Charlet A, Lelièvre V, Poisbeau P

Pain. 2018 Dec;159(12):2630-2640

A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline.

Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Théroux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M

J. Neurosci.. 2018 Nov 14;38(46):9934-9954

Stable Isotope-Labelled Morphine to Study in vivo Central and Peripheral Morphine Glucuronidation and Brain Transport in Tolerant Mice.

Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y

Br. J. Pharmacol.. 2018 Jul 26;:

Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod.

Itzhacki J, Clesse D, Goumon Y, Van Someren EJ, Mendoza J

Brain Struct Funct. 2018 Jul;223(6):2641-2652

Morphine Binds Creatine Kinase B and Inhibits Its Activity.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Delalande F, Marquette A, Chavant V, Gabel F, Cianferani S, Charlet A, Parat MO, Goumon Y

Front Cell Neurosci. 2018 ;12:464

Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide.

Roeckel LA, Utard V, Reiss D, Mouheiche J, Maurin H, Robé A, Audouard E, Wood JN, Goumon Y, Simonin F, Gaveriaux-Ruff C

Sci Rep. 2017 Sep;7(1):10406

Sleep Deprivation and Caffeine Treatment Potentiate Photic Resetting of the Master Circadian Clock in a Diurnal Rodent.

Jha PK, Bouâouda H, Gourmelen S, Dumont S, Fuchs F, Goumon Y, Bourgin P, Kalsbeek A, Challet E

J. Neurosci.. 2017 04 19;37(16):4343-4358

Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro.

Khabbazi S, Nassar ZD, Goumon Y, Parat MO

Sci Rep. 2016 08 12;6:31572

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.

Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana Del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demoulière N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V

Neuron. 2016 Mar 16;89(6):1291-1304

Neurophysiological responses to unpleasant stimuli (acute electrical stimulations and emotional pictures) are increased in patients with schizophrenia.

Duval CZ, Goumon Y, Kemmel V, Kornmeier J, Dufour A, Andlauer O, Vidailhet P, Poisbeau P, Salvat E, Muller A, Mensah-Nyagan AG, Schmidt-Mutter C, Giersch A

Sci Rep. 2016 Mar 3;6:22542

The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation .

Khabbazi S, Xie N, Pu W, Goumon Y, Parat MO

Front Pharmacol. 2016 ;7:441

Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.

Khabbazi S, Goumon Y, Parat MO

Sci Rep. 2015 Jun 16;5:11389

Defective response inhibition and collicular noradrenaline enrichment in mice with duplicated retinotopic map in the superior colliculus.

Mathis C, Savier E, Bott JB, Clesse D, Bevins N, Sage-Ciocca D, Geiger K, Gillet A, Laux-Biehlmann A, Goumon Y, Lacaud A, Lelièvre V, Kelche C, Cassel JC, Pfrieger FW, Reber M

Brain Struct Funct. 2015 ;220(3):1573-84

Endogenous morphine-6-glucuronide (M6G) is present in the plasma of patients: validation of a specific anti-M6G antibody for clinical and basic research.

Laux-Biehlmann A, Chung H, Mouheiche J, Veriepe J, Delalande F, Lamshoft M, Welters ID, Soldevila S, Bazin H, Lamarque L, Van Dorsselaer A, Poisbeau P, Schneider F, Goumon Y, Garnero P

Biofactors. 2014 Jan-Feb;40(1):113-20

CTIP2 is a negative regulator of P-TEFb.

Cherrier T, Le Douce V, Eilebrecht S, Riclet R, Marban C, Dequiedt F, Goumon Y, Paillart JC, Mericskay M, Parlakian A, Bausero P, Abbas W, Herbein G, Kurdistani SK, Grana X, Van Driessche B, Schwartz C, Candolfi E, Benecke AG, Van Lint C, Rohr O

Proc. Natl. Acad. Sci. U.S.A.. 2013 Jul;110(31):12655-60

Localization of endogenous morphine-like compounds in the mouse spinal cord.

Laux A, Delalande F, Mouheiche J, Stuber D, Van Dorsselaer A, Bianchi E, Bezard E, Poisbeau P, Goumon Y

J Comp Neurol. 2012 May 1;520(7):1547-61.

Endogenous morphine-like compound immunoreactivity increases in parkinsonism.

Charron G, Doudnikoff E, Laux A, Berthet A, Porras G, Canron MH, Barroso-Chinea P, Li Q, Qin C, Nosten-Bertrand M, Giros B, Delalande F, Van Dorsselaer A, Vital A, Goumon Y, Bezard E

Brain. 2011 Aug;134(Pt 8):2321-38

Mapping of endogenous morphine-like compounds in the adult mouse brain: Evidence of their localization in astrocytes and GABAergic cells.

Laux A, Muller AH, Miehe M, Dirrig-Grosch S, Deloulme JC, Delalande F, Stuber D, Sage D, Van Dorsselaer A, Poisbeau P, Aunis D, Goumon Y

J Comp Neurol. 2011 Aug 15;519(12):2390-416

Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine.

Charlet A, Muller AH, Laux A, Kemmel V, Schweitzer A, Deloulme JC, Stuber D, Delalande F, Bianchi E, Van Dorsselaer A, Aunis D, Andrieux A, Poisbeau P, Goumon Y

Mol Pain. 2010 Dec 20;6:96.

Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils.

Glattard E, Welters ID, Lavaux T, Muller AH, Laux A, Zhang D, Schmidt AR, Delalande F, Laventie BJ, Dirrig-Grosch S, Colin DA, Van Dorsselaer A, Aunis D, Metz-Boutigue MH, Schneider F, Goumon Y

PLoS One. 2010 Jan 20;5(1):e8791.

Characterization of human and bovine phosphatidylethanolamine-binding protein (PEBP/RKIP) interactions with morphine and morphine-glucuronides determined by noncovalent mass spectrometry.

Atmanene C, Laux A, Glattard E, Muller A, Schoentgen F, Metz-Boutigue MH, Aunis D, Van Dorsselaer A, Stefano GB, Sanglier-Cianferani S, Goumon Y

Med Sci Monit. 2009 Jul;15(7):BR178-87.

Identification of morphine-6-glucuronide in chromaffin cell secretory granules.

Goumon Y, Muller A, Glattard E, Marban C, Gasnier C, Strub JM, Chasserot-Golaz S, Rohr O, Stefano GB, Welters ID, Van Dorsselaer A, Schoentgen F, Aunis D, Metz-Boutigue MH

J Biol Chem. 2006 Mar 24;281(12):8082-9