Détail - canceropole-wordpress

Cholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties.

Kwarteng DO, Wolf A, Langdon M, Kassas N, Vitale N, Kooijman EE

J Lipid Res. 2025 01 27;:100749

Phospholipid Scramblase-1 controls efficient neurotransmission and synaptic vesicle retrieval at cerebellar synapses.

Caputo M, Ivanova D, Chasserot-Golaz S, Doussau F, Haeberlé AM, Royer C, Ozkan S, Ecard J, Vitale N, Cousin MA, Tóth P, Gasman S, Ory S

J Neurosci. 2024 06 5;:

Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes.

Okafor M, Champomier O, Raibaut L, Ozkan S, El Kholti N, Ory S, Chasserot-Golaz S, Gasman S, Hureau C, Faller P, Vitale N

Front Mol Biosci. 2024 04 5;11:1355963

The DDHD2-STXBP1 interaction mediates long-term memory via generation of saturated free fatty acids.

Akefe IO, Saber SH, Matthews B, Venkatesh BG, Gormal RS, Blackmore DG, Alexander S, Sieriecki E, Gambin Y, Bertran-Gonzalez J, Vitale N, Humeau Y, Gaudin A, Ellis SA, Michaels AA, Xue M, Cravatt B, Joensuu M, Wallis TP, Meunier FA

EMBO J. 2024 02 5;:

[Hormone secretion in pheochromocytoma: A dangerous story of poorly controlled vesicular exocytosis].

Streit L, Tanguy É, Brunaud L, Tóth P, Vitale N, Ory S, Gasman S

Med Sci (Paris). 2023 12;39(12):928-930

Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis.

Iyer DR, Venkatraman J, Tanguy E, Vitale N, Mahapatra NR

Cell Mol Life Sci. 2023 08 29;80(9):271

V-ATPase modulates exocytosis in neuroendocrine cells through the activation of the ARNO-Arf6-PLD pathway and the synthesis of phosphatidic acid.

Wang Q, Wolf A, Ozkan S, Richert L, Mely Y, Chasserot-Golaz S, Ory S, Gasman S, Vitale N

Front Mol Biosci. 2023 04 7;10:1163545

A Role for the V0 Sector of the V-ATPase in Neuroexocytosis: Exogenous V0d Blocks Complexin and SNARE Interactions with V0c.

Lévêque C, Maulet Y, Wang Q, Rame M, Rodriguez L, Mochida S, Sangiardi M, Youssouf F, Iborra C, Seagar M, Vitale N, El Far O

Cells. 2023 02 26;12(5):

Development of Cu(ii)-specific peptide shuttles capable of preventing Cu-amyloid beta toxicity and importing bioavailable Cu into cells.

Okafor M, Gonzalez P, Ronot P, El Masoudi I, Boos A, Ory S, Chasserot-Golaz S, Gasman S, Raibaut L, Hureau C, Vitale N, Faller P

Chem Sci. 2022 10 19;13(40):11829-11840

Parkin coordinates mitochondrial lipid remodeling to execute mitophagy.

Lin CC, Yan J, Kapur MD, Norris KL, Hsieh CW, Huang,Vitale N, Lim KL, Guan Z, Wang XF, Chi JT, Yang WY, Yao TP

EMBO Rep. 2022 10 18;:e55191

Phospholipase D and cancer metastasis: A focus on exosomes.

Wolf A, Tanguy E, Wang Q, Gasman S, Vitale N

Adv Biol Regul. 2022 10 14;:100924

ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites.

Guyard V, Monteiro-Cardoso VF, Omrane M, Sauvanet C, Houcine A, Boulogne C, Ben Mbarek K, Vitale N, Faklaris O, El Khallouki N, Thiam AR, Giordano F

J Cell Biol. 2022 09 5;221(9):

Dysfunction of calcium-regulated exocytosis at a single-cell level causes catecholamine hypersecretion in patients with pheochromocytoma.

Houy S, Streit L, Drissa I, Rame M, Decraene C, Moog S, Brunaud L, Lanoix J, Chelbi R, Bihain F, Lacomme S, Lomazzi S, Campoli P, Vix M, Mutter D, Paramithiotis E, Dubessy C, Vitale N, Ory S, Gasman S

Cancer Lett. 2022 06 6;:215765

Phospholipase D1-generated phosphatidic acid modulates secretory granule trafficking from biogenesis to compensatory endocytosis in neuroendocrine cells.

Tanguy E, Wolf A, Wang Q, Chasserot-Golaz S, Ory S, Gasman S, Vitale N

Adv Biol Regul. 2021 Nov 26;:100844

Somatostatin analogue pasireotide (SOM230) inhibits catecholamine secretion in human pheochromocytoma cells.

Streit L, Moog S, Hugel S, Rame M, Tanguy E, Andry V, Schmid HA, Brunaud L, Bihain F, Nominé-Criqui C, Goumon Y, Lacomme S, Lomazzi S, Vix M, Mutter D, Vitale N, Ory S, Gasman S

Cancer Lett. 2021 Oct 9;:

A Lipidomics Approach to Measure Phosphatidic Acid Species in Subcellular Membrane Fractions Obtained from Cultured Cells.

Kassas N, Fouillen L, Gasman S, Vitale N

Bio Protoc. 2021 Jun 20;11(12):e4066

Protocol for electron microscopy ultrastructural localization of the fusogenic lipid phosphatidic acid on plasma membrane sheets from chromaffin cells.

Tanguy E, Thahouly T, Royer C, Demais V, Gasman S, Chasserot-Golaz S, Vitale N

STAR Protoc. 2021 Jun 18;2(2):100464

Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes.

Ghoroghi S, Mary B, Larnicol A, Asokan N, Klein A, Osmani N, Busnelli I, Delalande F, Paul N, Halary S, Gros F, Fouillen L, Haeberle AM, Royer C, Spiegelhalter C, André-Grégoire G, Mittelheisser V, Detappe A, Murphy K, Timpson P, Carapito R, Blot-Chabaud M, Gavard J, Carapito C, Vitale N, Lefebvre O, Goetz JG, Hyenne V

Elife. 2021 Jan 6;10:

Bovine Chromaffin Cells: Culture and Fluorescence Assay for Secretion.

Thahouly T, Tanguy E, Raherindratsara J, Bader MF, Chasserot-Golaz S, Gasman S, Vitale N

Methods Mol Biol. 2021 ;2233:169-179

Measurements of Compensatory Endocytosis by Antibody Internalization and Quantification of Endocytic Vesicle Distribution in Adrenal Chromaffin Cells.

Ceridono M, Chasserot-Golaz S, Vitale N, Gasman S, Ory S

Methods Mol Biol. 2021 ;2233:43-51

Transmission Electron Microscopy and Tomography on Plasma Membrane Sheets to Study Secretory Docking.

Delavoie F, Royer C, Gasman S, Vitale N, Chasserot-Golaz S

Methods Mol Biol. 2021 ;2233:301-309

Phosphatidic acid: Mono- and poly-unsaturated forms regulate distinct stages of neuroendocrine exocytosis.

Tanguy E, Wolf A, Montero-Hadjadje M, Gasman S, Bader MF, Vitale N

Adv Biol Regul. 2020 Nov 28;:100772

Annexin A2 Egress during Calcium-Regulated Exocytosis in Neuroendocrine Cells.

Gabel M, Royer C, Thahouly T, Calco V, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S

Cells. 2020 Sep 9;9(9):

Mono- and Poly-unsaturated Phosphatidic Acid Regulate Distinct Steps of Regulated Exocytosis in Neuroendocrine Cells.

Tanguy E, Costé de Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberlé AM, Raherindratsara J, Fouillen L, Renard PY, Montero-Hadjadje M, Chasserot-Golaz S, Ory S, Gasman S, Bader MF, Vitale N

Cell Rep. 2020 Aug 18;32(7):108026

The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways.

Gubar O, Croisé P, Kropyvko S, Gryaznova T, Toth P, Blangy A, Vitale N, Rynditch A, Gasman S, Ory S

J. Cell. Sci.. 2020 Jul 31;:

Hormones Secretion and Rho GTPases in Neuroendocrine Tumors.

Streit L, Brunaud L, Vitale N, Ory S, Gasman S

Cancers (Basel). 2020 Jul 10;12(7):

High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.

Dugail I, Amri EZ, Vitale N

Biochimie. 2020 Jul 7;:

Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.

Guillen-Chable F, Corona UR, Pereira-Santana A, Bayona A, Rodríguez-Zapata LC, Aquino C, Šebestová L, Vitale N, Hozak P, Castano E

Cells. 2020 May 6;9(5):

The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells.

Shi W, Ye B, Rame M, Wang Y, Ciocca D, Reibel Foisset S, Peng J, Qi S, Vitale N, Luo H, Wu J

J. Biol. Chem.. 2020 Apr 22;:

Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis.

Carmon O, Laguerre F, Riachy L, Delestre-Delacour C, Wang Q, Tanguy E, Jeandel L, Cartier D, Thahouly T, Haeberlé AM, Fouillen L, Rezazgui O, Schapman D, Haefelé A, Goumon Y, Galas L, Renard PY, Alexandre S, Vitale N, Anouar Y, Montero-Hadjadje M

FASEB J.. 2020 Mar 29;:

Phosphatidic acid metabolism regulates neuroendocrine secretion but is not under the direct control of lipins.

Baneux C, Tanguy E, Thahouly T, Vitale A, Chasserot-Golaz S, Bader MF, Gasman S, Vitale N

IUBMB Life. 2020 Jan 22;:

The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways.

Gubar O, Croisé P, Kropyvko S, Gryaznova T, Toth P, Blangy A, Vitale N, Rynditch A, Gasman S, Ory S

J Cell Sci. 2020 Jan 1;:

αII-spectrin controls calcium-regulated exocytosis in neuroendocrine chromaffin cells through neuronal Wiskott-Aldrich Syndrome protein interaction.

Houy S, Nicolas G, Momboisse F, Malacombe M, Bader MF, Vitale N, Lecomte MC, Ory S, Gasman S

IUBMB Life. 2019 Dec 20;:

EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells.

Shi W, Wang Y, Peng J, Qi S, Vitale N, Kaneda N, Murata T, Luo H, Wu J

J. Biol. Chem.. 2019 Apr 26;294(17):6871-6887

Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis.

Tanguy E, Tran Nguyen AP, Kassas N, Bader MF, Grant NJ, Vitale N

J. Immunol.. 2019 Apr 3;:

Effects of phospholipase D during cultured osteoblast mineralization and bone formation.

Abdallah D, Skafi N, Hamade E, Borel M, Reibel S, Vitale N, El Jamal A, Bougault C, Laroche N, Vico L, Badran B, Hussein N, Magne D, Buchet R, Brizuela L, Mebarek S

J. Cell. Biochem.. 2019 Apr;120(4):5923-5935

Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.

Skafi N, Abdallah D, Soulage C, Reibel S, Vitale N, Hamade E, Faour W, Magne D, Badran B, Hussein N, Buchet R, Brizuela L, Mebarek S

J. Cell. Physiol.. 2019 Apr;234(4):4825-4839

Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells.

Gabel M, Delavoie F, Royer C, Tahouly T, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S

Biochim Biophys Acta Mol Cell Res. 2019 Jan 2;:

Of local translation control and lipid signaling in neurons.

Moine H, Vitale N

Adv Biol Regul. 2019 Jan;71:194-205

Phosphatidic Acid: From Pleiotropic Functions to Neuronal Pathology.

Tanguy E, Wang Q, Moine H, Vitale N

Front Cell Neurosci. 2019 ;13:2

Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease.

Tanguy E, Wang Q, Vitale N

Handb Exp Pharmacol. 2018 Dec 21;:

Cholesterol and the journey of extracellular vesicles.

Pfrieger FW, Vitale N

J. Lipid Res.. 2018 12;59(12):2255-2261

The caveolae-associated coiled-coil protein, NECC2, regulates insulin signalling in Adipocytes.

Trávez A, Rabanal-Ruiz Y, López-Alcalá J, Molero-Murillo L, Díaz-Ruiz A, Guzmán-Ruiz R, Catalán V, Rodríguez A, Frühbeck G, Tinahones FJ, Gasman S, Vitale N, Jiménez-Gómez Y, Malagón MM

J. Cell. Mol. Med.. 2018 Aug 30;:

Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells.

Chopard C, Tong PBV, Tóth P, Schatz M, Yezid H, Debaisieux S, Mettling C, Gross A, Pugnière M, Tu A, Strub JM, Mesnard JM, Vitale N, Beaumelle B

Nat Commun. 2018 06 8;9(1):2251

Protein⁻Phospholipid Interaction Motifs: A Focus on Phosphatidic Acid.

Tanguy E, Kassas N, Vitale N

Biomolecules. 2018 04 23;8(2):

Phosphatidylinositol (4,5)-bisphosphate-mediated pathophysiological effect of HIV-1 Tat protein.

Beaumelle B, Tóth P, Malak OA, Chopard C, Loussouarn G, Vitale N

Biochimie. 2017 Oct;141:80-85

Lipid remodeling in neuroendocrine secretion.

Gasman S, Vitale N

Biol. Cell. 2017 Sep;:

Meeting after meeting: 20 years of discoveries by the members of the Exocytosis-Endocytosis Club.

Niedergang F, Gasman S, Vitale N, Desnos C, Lamaze C

Biol. Cell. 2017 Jul;:

Comparative Characterization of Phosphatidic Acid Sensors and Their Localization during Frustrated Phagocytosis.

Kassas N, Tanguy E, Thahouly T, Fouillen L, Heintz D, Chasserot-Golaz S, Bader MF, Grant NJ, Vitale N

J. Biol. Chem.. 2017 Mar;292(10):4266-4279

Dietary arachidonic acid as a risk factor for age-associated neurodegenerative diseases: Potential mechanisms.

Thomas MH, Pelleieux S, Vitale N, Olivier JL

Biochimie. 2016 Nov;130:168-177

Fragile X syndrome: Are signaling lipids the missing culprits?

Tabet R, Vitale N, Moine H

Biochimie. 2016 Nov;130:188-194

Lipidomics and functional lipid biology.

Schaller H, Vitale N

Biochimie. 2016 Nov;130:1-3

Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.

Tabet R, Moutin E, Becker JA, Heintz D, Fouillen L, Flatter E, Krężel W, Alunni V, Koebel P, Dembélé D, Tassone F, Bardoni B, Mandel JL, Vitale N, Muller D, Le Merrer J, Moine H

Proc. Natl. Acad. Sci. U.S.A.. 2016 06;113(26):E3619-28

Lipids implicated in the journey of a secretory granule: from biogenesis to fusion.

Tanguy E, Carmon O, Wang Q, Jeandel L, Chasserot-Golaz S, Montero-Hadjadje M, Vitale N

J. Neurochem.. 2016 Jun;137(6):904-12

Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.

Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S

J Cell Biol. 2015 Aug 31;210(5):785-800

Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells.

Houy S, Estay-Ahumada C, Croise P, Calco V, Haeberle AM, Bailly Y, Billuart P, Vitale N, Bader MF, Ory S, Gasman S

J Neurosci. 2015 Aug 5;35(31):11045-55

ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.

Pelletán LE, Suhaiman L, Vaquer CC, Bustos MA, De Blas GA, Vitale N, Mayorga LS, Belmonte SA

J. Biol. Chem.. 2015 Apr 10;290(15):9823-41

Phosphatidic acid in neuronal development: a node for membrane and cytoskeleton rearrangements.

Ammar MR, Kassas N, Bader MF, Vitale N

Biochimie. 2014 Dec;107 Pt A:51-7

Lack of the presynaptic RhoGAP protein oligophrenin1 leads to cognitive disabilities through dysregulation of the cAMP/PKA signalling pathway.

Khelfaoui M, Gambino F, Houbaert X, Ragazzon B, Muller C, Carta M, Lanore F, Srikumar BN, Gastrein P, Lepleux M, Zhang CL, Kneib M, Poulain B, Reibel-Foisset S, Vitale N, Chelly J, Billuart P, Luthi A, Humeau Y

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130160

The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid.

Ammar MR, Humeau Y, Hanauer A, Nieswandt B, Bader MF, Vitale N

J Neurosci. 2013 Dec 11;33(50):19470-9

[HIV-associated cognitive disorders: tat perturbs neurosecretion].

Tryoen-Toth P, Beaumelle B, Bader MF, Vitale N

Med Sci (Paris). 2013 Dec;29(12):1069-70

HIV-1 Tat protein perturbs diacylglycerol production at the plasma membrane of neurosecretory cells during exocytosis.

Vitale N, Beaumelle B, Bader MF, Tryoen-Toth P

Commun Integr Biol. 2013 Sep 1;6(5):e25145

Ephrin B1 maintains apical adhesion of neural progenitors.

Arvanitis DN, Béhar A, Tryoen-Tóth P, Bush JO, Jungas T, Vitale N, Davy A

Development. 2013 May;140(10):2082-92

HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate.

Tryoen-Toth P, Chasserot-Golaz S, Tu A, Gherib P, Bader MF, Beaumelle B, Vitale N

J Cell Sci. 2013 Jan 15;126(Pt 2):454-63

Lipids in Regulated Exocytosis: What are They Doing?

Ammar MR, Kassas N, Chasserot-Golaz S, Bader MF, Vitale N

Front Endocrinol (Lausanne). 2013 Sep 17;4:125

The long coiled-coil protein NECC2 is associated to caveolae and modulates NGF/TrkA signaling in PC12 cells.

Diaz-Ruiz A, Rabanal-Ruiz Y, Travez A, Gracia-Navarro F, Cruz-Garcia D, Montero-Hadjadje M, Anouar Y, Gasman S, Vitale N, Vazquez-Martinez R, Malagon MM

PLoS One. 2013 Sep 6;8(9):e73668

Genetically encoded probes for phosphatidic acid.

Kassas N, Tryoen-Toth P, Corrotte M, Thahouly T, Bader MF, Grant NJ, Vitale N

Methods Cell Biol. 2012;108:445-59.

Lipid dynamics in exocytosis.

Chasserot-Golaz S, Coorssen JR, Meunier FA, Vitale N

Cell. Mol. Neurobiol.. 2010 Nov;30(8):1335-42

Melittin promotes exocytosis in neuroendocrine cells through the activation of phospholipase A.

Vitale N, Thierse D, Bader MF

Regul Pept. 2010 Nov 30;165(1):111-6

The Rho guanine nucleotide exchange factors Intersectin 1L and beta-Pix control calcium-regulated exocytosis in neuroendocrine PC12 cells.

Momboisse F, Ory S, Ceridono M, Calco V, Vitale N, Bader MF, Gasman S

Cell Mol Neurobiol. 2010 Nov;30(8):1327-33

Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA.

Corrotte M, Nyguyen AP, Harlay ML, Vitale N, Bader MF, Grant NJ

J Immunol. 2010 Sep 1;185(5):2942-50

IL1RAPL1 controls inhibitory networks during cerebellar development in mice.

Gambino F, Kneib M, Pavlowsky A, Skala H, Heitz S, Vitale N, Poulain B, Khelfaoui M, Chelly J, Billuart P, Humeau Y

Eur. J. Neurosci.. 2009 Oct;30(8):1476-86

Phospholipase D in calcium-regulated exocytosis: lessons from chromaffin cells.

Bader MF, Vitale N

Biochim Biophys Acta. 2009 Sep;1791(9):936-41

X-linked mental retardation: focus on synaptic function and plasticity.

Humeau Y, Gambino F, Chelly J, Vitale N

J. Neurochem.. 2009 Apr;109(1):1-14

betaPIX-activated Rac1 stimulates the activation of phospholipase D, which is associated with exocytosis in neuroendocrine cells.

Momboisse F, Lonchamp E, Calco V, Ceridono M, Vitale N, Bader MF, Gasman S

J Cell Sci. 2009 Mar 15;122(Pt 6):798-806.

ARF6 regulates the synthesis of fusogenic lipids for calcium-regulated exocytosis in neuroendocrine cells.

Begle A, Tryoen-Toth P, de Barry J, Bader MF, Vitale N

J Biol Chem. 2009 Feb 20;284(8):4836-45

Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells.

Disse J, Vitale N, Bader MF, Gerke V

Blood. 2009 Jan;113(4):973-80

The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.

Zeniou-Meyer M, Begle A, Bader MF, Vitale N

Ann N Y Acad Sci. 2009 Jan;1152:201-8.

The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.

Zeniou-Meyer M, Liu Y, Begle A, Olanish M, Hanauer A, Becherer U, Rettig J, Bader MF, Vitale N

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8434-9

SNARE-catalyzed fusion events are regulated by Syntaxin1A-lipid interactions.

Lam AD, Tryoen-Toth P, Tsai B, Vitale N, Stuenkel EL

Mol. Biol. Cell. 2008 Feb;19(2):485-97

Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage.

Zeniou-Meyer M, Zabari N, Ashery U, Chasserot-Golaz S, Haeberle AM, Demais V, Bailly Y, Gottfried I, Nakanishi H, Neiman AM, Du G, Frohman MA, Bader MF, Vitale N

J Biol Chem. 2007 Jul 27;282(30):21746-57