Harmouch E, Seitlinger J, Chaddad H, Ubeaud-Sequier G, Barths J, Saidu S, Désaubry L, Grandemange S, Massfelder T, Fuhrmann G, Fioretti F, Dontenwill M, Benkirane-Jessel N, Idoux-Gillet Y

Sci Rep. 2020 Aug 13;10(1):13750

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1.

Hassan S, Peluso J, Chalhoub S, Idoux Gillet Y, Benkirane-Jessel N, Rochel N, Fuhrmann G, Ubeaud-Sequier G

PLoS One. 2020 ;15(10):e0240676

The synthetic flavagline FL3 spares normal human skin cells from its cytotoxic effect via an activation of Bad.

Emhemmed F, Azouaou SA, Hassan S, Lefevbre R, Désaubry L, Muller CD, Fuhrmann G

Toxicol In Vitro. 2019 Apr 24;:

Combining 2D angiogenesis and 3D osteosarcoma microtissues to improve vascularization.

Chaddad H, Kuchler-Bopp S, Fuhrmann G, Gegout H, Ubeaud-Sequier G, Schwinté P, Bornert F, Benkirane-Jessel N, Idoux-Gillet Y

Exp. Cell Res.. 2017 11 15;360(2):138-145

Pro-differentiating effects of a synthetic flavagline on human teratocarcinomal cancer stem-like cells.

Emhemmed F, Ali Azouaou S, Zhao Q, Appert-Collin A, Bennasroune A, Schini-Kerth VB, Muller CD, Désaubry L, Fuhrmann G

Cell Biol. Toxicol.. 2016 Dec;:

Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix.

Appert-Collin A, Bennasroune A, Jeannesson P, Terryn C, Fuhrmann G, Morjani H, Dedieu S

Cell Adh Migr. 2016 Jul;:1-11

Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells.

Ali Azouaou S, Emhemmed F, Idris-Khodja N, Lobstein A, Schini-Kerth V, Muller CD, Fuhrmann G

Invest New Drugs. 2015 Feb;33(1):64-74

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.

Emhemmed F, Ali Azouaou S, Thuaud F, Schini-Kerth V, Desaubry L, Muller CD, Fuhrmann G

Biochem Pharmacol. 2014 May 15;89(2):185-96

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.

Sharif T, Alhosin M, Auger C, Minker C, Kim JH, Etienne-Selloum N, Bories P, Gronemeyer H, Lobstein A, Bronner C, Fuhrmann G, Schini-Kerth VB

PLoS One. 2012;7(3):e32526

Selective proapoptotic activity of polyphenols from red wine on teratocarcinoma cell, a model of cancer stem-like cell.

Sharif T, Auger C, Bronner C, Alhosin M, Klein T, Etienne-Selloum N, Schini-Kerth VB, Fuhrmann G

Invest New Drugs. 2011 Apr;29(2):239-47

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C

Cell Signal. 2011 Jan;23(1):152-60

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties.

Alhosin M, Sharif T, Mousli M, Etienne-Selloum N, Fuhrmann G, Schini-Kerth VB, Bronner C

J Exp Clin Cancer Res. 2011 Apr 15;30:41.

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1.

Alhosin M, Abusnina A, Achour M, Sharif T, Muller C, Peluso J, Chataigneau T, Lugnier C, Schini-Kerth VB, Bronner C, Fuhrmann G

Biochem Pharmacol. 2010 May 1;79(9):1251-60

Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1.

Sharif T, Auger C, Alhosin M, Ebel C, Achour M, Etienne-Selloum N, Fuhrmann G, Bronner C, Schini-Kerth VB

Eur J Cancer. 2010 Mar;46(5):983-94

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Dr FUHRMANN Guy

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Effets anticancéreux pro-différenciateurs de la flavagline synthétique FL3 sur les cellules souches cancéreuses humaines

Effets anticancéreux pro-différenciateurs de la flavagline synthétique FL3 sur les cellules souches cancéreuses humaines

Effets anticancéreux de la flavagline synthétique FL3 sur les cellules souches tératocarcinomales humaines

Publications

Flavagline synthetic derivative induces senescence in glioblastoma cancer cells without being toxic to healthy astrocytes.