Dr COMPE Emmanuel

Fiche personne

Coordonnées

IGBMC
1 rue Laurent Fries
BP 10142
67404 ILLKIRCH Cedex

Territoire

Alsace

Statut

Chercheur

Affiliation

IGBMC - Institut de génétique et de biologie moléculaire et cellulaire (IGBMC)

Équipes/plateformes

Equipe Equipe "Genomique fonctionnelle et cancer / Expression et réparation du génome"

Projets

Cancers cutanés et défauts transcriptionnels dans des maladies de la réparation

2013 - Porteur du projet : Dr COMPE Emmanuel

Publications

Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability.

Berico P, Nogaret M, Cigrang M, Lallement A, Vand-Rajabpour F, Flores-Yanke A, Gambi G, Davidson G, Seno L, Obid J, Vokshi BH, Le Gras S, Mengus G, Ye T, Cordero CF, Dalmasso M, Compe E, Bertolotto C, Hernando E, Davidson I, Coin F

Cell Rep. 2023 11 2;42(11):113363

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.

Sandoz J, Cigrang M, Zachayus A, Catez P, Donnio LM, Elly C, Nieminuszczy J, Berico P, Braun C, Alekseev S, Egly JM, Niedzwiedz W, Giglia-Mari G, Compe E, Coin F

Nat Commun. 2023 01 20;14(1):341

Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions.

Compe E, Pangou E, Le May N, Elly C, Braun C, Hwang JH, Coin F, Sumara I, Choi KW, Egly JM

Sci Adv. 2022 08 19;8(33):eabp9457

Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells.

Costanzo F, Martínez Diez M, Santamaría Nuñez G, Díaz-Hernandéz JI, Genes Robles CM, Díez Pérez J, Compe E, Ricci R, Li TK, Coin F, Martínez Leal JF, Garrido-Martin EM, Egly JM

EMBO Mol Med. 2022 Mar 9;:e14841

HR-Bac, a toolbox based on homologous recombination for expression, screening and production of multiprotein complexes using the baculovirus expression system.

Kolesnikova O, Zachayus A, Pichard S, Osz J, Rochel N, Rossolillo P, Kolb-Cheynel I, Troffer-Charlier N, Compe E, Bensaude O, Berger I, Poterszman A

Sci Rep. 2022 02 7;12(1):2030

CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma.

Berico P, Cigrang M, Davidson G, Braun C, Sandoz J, Legras S, Vokshi BH, Slovic N, Peyresaubes F, Gene Robles CM, Egly JM, Compe E, Davidson I, Coin F

EMBO Rep. 2021 Jul 23;:e51683

Reduced levels of prostaglandin I synthase: a distinctive feature of the cancer-free trichothiodystrophy.

Lombardi A, Arseni L, Carriero R, Compe E, Botta E, Ferri D, Uggè M, Biamonti G, Peverali FA, Bione S, Orioli D

Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):

The Long Road to Understanding RNAPII Transcription Initiation and Related Syndromes.

Compe E, Egly JM

Annu Rev Biochem. 2021 Jun 20;90:193-219

A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression.

Pangou E, Bielska O, Guerber L, Schmucker S, Agote-Arán A, Ye T, Liao Y, Puig-Gamez M, Grandgirard E, Kleiss C, Liu Y, Compe E, Zhang Z, Aebersold R, Ricci R, Sumara I

Cell Rep. 2021 May 18;35(7):109129

Dysregulation of LXR responsive genes contribute to ichthyosis in trichothiodystrophy.

Hashimoto S, Takanari H, Compe E, Egly JM

J. Dermatol. Sci.. 2020 Jan 24;:

TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription.

Compe E, Genes CM, Braun C, Coin F, Egly JM

Nat Commun. 2019 May 7;10(1):2084

Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.

Santamaría Nuñez G, Robles CM, Giraudon C, Martínez-Leal JF, Compe E, Coin F, Aviles P, Galmarini CM, Egly JM

Mol. Cancer Ther.. 2016 Oct;15(10):2399-2412

Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.

Compe E, Egly JM

Annu. Rev. Biochem.. 2016 Jun;85:265-90

TFIIH subunit alterations causing xeroderma pigmentosum and trichothiodystrophy specifically disturb several steps during transcription.

Singh A, Compe E, Le May N, Egly JM

Am J Hum Genet. 2015 Feb 5;96(2):194-207

TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.

Arseni L, Lanzafame M, Compe E, Fortugno P, Afonso-Barroso A, Peverali FA, Lehmann AR, Zambruno G, Egly JM, Stefanini M, Orioli D

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1499-504

Dynamic partnership between TFIIH, PGC-1alpha and SIRT1 is impaired in trichothiodystrophy.

Traboulsi H, Davoli S, Catez P, Egly JM, Compe E

PLoS Genet. 2014 Oct 23;10(10):e1004732

Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.

Zhou X, Khan SG, Tamura D, Ueda T, Boyle J, Compe E, Egly JM, DiGiovanna JJ, Kraemer KH

Eur J Hum Genet. 2013 Aug;21(8):831-7

XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.

Orioli D, Compe E, Nardo T, Mura M, Giraudon C, Botta E, Arrigoni L, Peverali FA, Egly JM, Stefanini M

Hum Mol Genet. 2013 Mar 15;22(6):1061-73

XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients.

Ito S, Kuraoka I, Chymkowitch P, Compe E, Takedachi A, Ishigami C, Coin F, Egly JM, Tanaka K

Mol Cell. 2007 Apr 27;26(2):231-43.

Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.

Compe E, Drane P, Laurent C, Diderich K, Braun C, Hoeijmakers JH, Egly JM

Mol Cell Biol. 2005 Jul;25(14):6065-76.

Selective regulation of vitamin D receptor-responsive genes by TFIIH.

Drané P, Compe E, Catez P, Chymkowitch P, Egly JM

Mol. Cell. 2004 Oct;16(2):187-97

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