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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity.

Cigrang M, Obid J, Nogaret M, Seno L, Ye T, Davidson G, Catez P, Berico P, Capelli C, Marechal C, Zachayus A, Elly C, Guillen Navarro MJ, Martinez Diez M, Santamaria Nunez G, Li TK, Compe E, Avilés P, Davidson I, Egly JM, Cuevas C, Coin F

Nat Commun. 2025 01 8;16(1):512

Transcription: friend or foe of genome stability.

Compe E, Orioli D

FEBS Lett. 2025 01;599(2):143-146

Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability.

Berico P, Nogaret M, Cigrang M, Lallement A, Vand-Rajabpour F, Flores-Yanke A, Gambi G, Davidson G, Seno L, Obid J, Vokshi BH, Le Gras S, Mengus G, Ye T, Cordero CF, Dalmasso M, Compe E, Bertolotto C, Hernando E, Davidson I, Coin F

Cell Rep. 2023 11 2;42(11):113363

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