Goto A, Okado K, Martins N, Cai H, Barbier V, Lamiable O, Troxler L, Santiago E, Kuhn L, Paik D, Silverman N, Holleufer A, Hartmann R, Liu J, Peng T, Hoffmann JA, Meignin C, Daeffler L, Imler JL

Immunity. 2018 Aug 21;49(2):225-234.e4

Efficient Detection of Long dsRNA and Using the dsRNA Binding Domain from FHV B2 Protein.

Monsion B, Incarbone M, Hleibieh K, Poignavent V, Ghannam A, Dunoyer P, Daeffler L, Tilsner J, Ritzenthaler C

Front Plant Sci. 2018 ;9:70

Innate and intrinsic antiviral immunity in Drosophila.

Mussabekova A, Daeffler L, Imler JL

Cell. Mol. Life Sci.. 2017 06;74(11):2039-2054

Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.

Lamiable O, Kellenberger C, Kemp C, Troxler L, Pelte N, Boutros M, Marques JT, Daeffler L, Hoffmann JA, Roussel A, Imler JL

Proc. Natl. Acad. Sci. U.S.A.. 2016 Jan 19;113(3):698-703

Drosophila C virus systemic infection leads to intestinal obstruction.

Chtarbanova S, Lamiable O, Lee KZ, Galiana D, Troxler L, Meignin C, Hetru C, Hoffmann JA, Daeffler L, Imler JL

J. Virol.. 2014 Dec;88(24):14057-69

Generation of an adenovirus-parvovirus chimera with enhanced oncolytic potential.

El-Andaloussi N, Bonifati S, Kaufmann JK, Mailly L, Daeffler L, Deryckere F, Nettelbeck DM, Rommelaere J, Marchini A

J Virol. 2012 Oct;86(19):10418-31

Through its nonstructural protein NS1, parvovirus H-1 induces apoptosis via accumulation of reactive oxygen species.

Hristov G, Kramer M, Li J, El-Andaloussi N, Mora R, Daeffler L, Zentgraf H, Rommelaere J, Marchini A

J Virol. 2010 Jun;84(12):5909-22

Vesicular egress of non-enveloped lytic parvoviruses depends on gelsolin functioning.

Bar S, Daeffler L, Rommelaere J, Nuesch JP

PLoS Pathog. 2008 Aug 15;4(8):e1000126.

Phosphorylation on Ser106 modulates the cellular functions of the SHOX homeodomain protein.

Marchini A, Daeffler L, Marttila T, Schneider KU, Blaschke RJ, Schnolzer M, Rommelaere J, Rappold G

J Mol Biol. 2006 Jan 20;355(3):590-603

Inhibition of GTPase activity of Gi proteins and decreased agonist affinity at M2 muscarinic acetylcholine receptors by spermine and methoctramine.

Daeffler L, Chahdi A, Gies JP, Landry Y

Br. J. Pharmacol.. 1999 Jun;127(4):1021-9

Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors.

Daeffler L, Schmidlin F, Gies JP, Landry Y

Br. J. Pharmacol.. 1999 Mar;126(5):1246-52

Interleukin-1beta induces bradykinin B2 receptor gene expression through a prostanoid cyclic AMP-dependent pathway in human bronchial smooth muscle cells.

Schmidlin F, Scherrer D, Daeffler L, Bertrand C, Landry Y, Gies JP

Mol. Pharmacol.. 1998 Jun;53(6):1009-15

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Dr DAEFFLER Laurent

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Projets

Modification du microenvironnement tumoral de l'adénocarcinome pancréatique par un virus oncolytique (MOMENTUM)

Publications

Oncolytic Rodent Protoparvoviruses Evade a TLR- and RLR-Independent Antiviral Response in Transformed Cells.

Invading viral DNA triggers dsRNA synthesis by RNA polymerase II to activate antiviral RNA interference in Drosophila.

Wide spectrum and high frequency of genomic structural variation, including transposable elements, in large double-stranded DNA viruses.

Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study.

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila.