Lin X, Gupta D, Vaitsiankova A, Bhandari SK, Leung KSK, Menolfi D, Lee BJ, Russell HR, Gershik S, Huang X, Gu W, McKinnon PJ, Dantzer F, Rothenberg E, Tomkinson AE, Zha S

Mol Cell. 2024 10 4;:

Enhancing Cisplatin Drug Sensitivity through PARP3 Inhibition: The Influence on PDGF and G-Coupled Signal Pathways in Cancer.

Varol A, Klauck SM, Dantzer F, Efferth T

Chem Biol Interact. 2024 06 1;:111094

PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine.

Bencsics M, Bányai B, Ke H, Csépányi-Kömi R, Sasvári P, Dantzer F, Hanini N, Benkő R, Horváth EM

Front Immunol. 2023 06 30;14:1135410

Purification of Recombinant Human PARG and Activity Assays.

Amé JC, Dantzer F

Methods Mol Biol. 2023 ;2609:399-418

Purification of Recombinant Human PARP-3.

Amé JC, Nguekeu-Zebase L, Harwood D, Yildirim Z, Roegel L, Boos A, Dantzer F

Methods Mol Biol. 2023 ;2609:419-441

PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells.

Nguekeu-Zebaze L, Hanini N, Noll A, Wadier N, Amé JC, Roegel L, Dantzer F

Sci Rep. 2022 09 15;12(1):15534

Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss.

Kelleher AM, Setlem R, Dantzer F, DeMayo FJ, Lydon JP, Kraus WL

Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):

Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice.

Galindo-Campos MA, Lutfi N, Bonnin S, Martínez C, Velasco-Hernandez T, García-Hernández V, Martin-Caballero J, Ampurdanés C, Gimeno R, Colomo L, Roue G, Guilbaud G, Dantzer F, Navarro P, Murga M, Fernandez-Capetillo O, Bigas A, Menendez P, Sale J, Yélamos J

Blood. 2021 Aug 6;:

ADP-ribosyltransferases, an update on function and nomenclature.

Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M

FEBS J. 2021 Jul 29;:

Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.

Rodriguez-Vargas JM, Martin-Hernandez K, Wang W, Kunath N, Suganthan R, Amé JC, Oliver FJ, Ye J, Bjørås M, Dantzer F

Cell Death Dis. 2020 Nov 6;11(11):954

Coordinated signals from PARP-1 and PARP-2 are required to establish a proper T cell immune response to breast tumors in mice.

Moreno-Lama L, Galindo-Campos MA, Martínez C, Comerma L, Vazquez I, Vernet-Tomas M, Ampurdanés C, Lutfi N, Martin-Caballero J, Dantzer F, Quintela-Fandino M, Ali SO, Jimeno J, Yélamos J

Oncogene. 2020 Jan 30;:

Therapeutic considerations of PARP in stem cell biology: relevance in cancer and beyond.

Zeniou M, Nguekeu-Zebaze L, Dantzer F

Biochem. Pharmacol.. 2019 Jun 13;:

PARP3 comes to light as a prime target in cancer therapy.

Rodriguez-Vargas JM, Nguekeu-Zebaze L, Dantzer F

Cell Cycle. 2019 May 16;:

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.

Galindo-Campos MA, Bedora-Faure M, Farrés J, Lescale C, Moreno-Lama L, Martínez C, Martín-Caballero J, Ampurdanés C, Aparicio P, Dantzer F, Cerutti A, Deriano L, Yélamos J

Cell Death Differ.. 2019 Apr 17;:

PARP1 and Poly(ADP-ribosyl)ation Signaling during Autophagy in Response to Nutrient Deprivation.

Rodríguez-Vargas JM, Oliver-Pozo FJ, Dantzer F

Oxid Med Cell Longev. 2019 ;2019:2641712

PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers.

Beck C, Rodriguez-Vargas JM, Boehler C, Robert I, Heyer V, Hanini N, Gauthier LR, Tissier A, Schreiber V, Elofsson M, Reina San Martin B, Dantzer F

Cell Death Differ.. 2018 Nov 15;:

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage.

Chen Q, Kassab MA, Dantzer F, Yu X

Nat Commun. 2018 Aug 13;9(1):3233

PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.

Dörsam B, Seiwert N, Foersch S, Stroh S, Nagel G, Begaliew D, Diehl E, Kraus A, McKeague M, Minneker V, Roukos V, Reißig S, Waisman A, Moehler M, Stier A, Mangerich A, Dantzer F, Kaina B, Fahrer J

Proc. Natl. Acad. Sci. U.S.A.. 2018 Apr 24;115(17):E4061-E4070

PARP2 deficiency affects invariant-NKT-cell maturation and protects mice from Concanavalin A-induced liver injury.

Filliol A, Piquet-Pellorce C, Dion S, Genet V, Lucas-Clerc C, Dantzer F, Samson M

Am. J. Physiol. Gastrointest. Liver Physiol.. 2017 Jul;:ajpgi.00436.2016

Expanding functions of ADP-ribosylation in the maintenance of genome integrity.

Martin-Hernandez K, Rodriguez-Vargas JM, Schreiber V, Dantzer F

Semin. Cell Dev. Biol.. 2017 Mar;63:92-101

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas.

Navarro J, Gozalbo-López B, Méndez AC, Dantzer F, Schreiber V, Martínez C, Arana DM, Farrés J, Revilla-Nuin B, Bueno MF, Ampurdanés C, Galindo-Campos MA, Knobel PA, Segura-Bayona S, Martin-Caballero J, Stracker TH, Aparicio P, Del Val M, Yélamos J

Sci Rep. 2017 Feb;7:41962

Purification of Recombinant Human PARG and Activity Assays.

Amé JC, Héberlé É, Camuzeaux B, Dantzer F, Schreiber V

Methods Mol. Biol.. 2017 ;1608:395-413

Purification of Recombinant Human PARP-3.

Amé JC, Camuzeaux B, Dantzer F, Schreiber V

Methods Mol. Biol.. 2017 ;1608:373-394

Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice.

Robert I, Gaudot L, Yélamos J, Noll A, Wong HK, Dantzer F, Schreiber V, Reina-San-Martin B

Eur. J. Immunol.. 2017 Jan;:

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.

Rodríguez-Vargas JM, Rodríguez MI, Majuelos-Melguizo J, García-Diaz Á, González-Flores A, López-Rivas A, Virág L, Illuzzi G, Schreiber V, Dantzer F, Oliver FJ

Cell Death Differ.. 2016 Dec;23(12):2007-2018

Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.

Ghosh R, Roy S, Kamyab J, Dantzer F, Franco S

DNA Repair (Amst.). 2016 Sep;45:56-62

PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis.

Karicheva O, Rodriguez-Vargas JM, Wadier N, Martin-Hernandez K, Vauchelles R, Magroun N, Tissier A, Schreiber V, Dantzer F

Oncotarget. 2016 Sep;7(39):64109-64123

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, Freund JN, Domon-Dell C

Cancer Lett.. 2016 May;374(2):208-15

A PARP1-ERK2 synergism is required for the induction of LTP.

Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M

Sci Rep. 2016 Apr;6:24950

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency.

Noll A, Illuzzi G, Amé JC, Dantzer F, Schreiber V

Cancer Cell Int.. 2016 ;16:53

[From poly(ADP-ribose) discovery to PARP inhibitors in cancer therapy].

Schreiber V, Illuzzi G, Heberle E, Dantzer F

Bull Cancer. 2015 Sep 15. pii: S0007-4551(15)00243-X

Parp3 negatively regulates immunoglobulin class switch recombination.

Robert I, Gaudot L, Rogier M, Heyer V, Noll A, Dantzer F, Reina-San-Martin B

PLoS Genet.. 2015 May;11(5):e1005240

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

Farres J, Llacuna L, Martin-Caballero J, Martinez C, Lozano JJ, Ampurdanes C, Lopez-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernandez-Capetillo O, Yelamos J

Cell Death Differ. 2014 Dec 12

Poly(ADP-ribose) polymerases in double-strand break repair: focus on PARP1, PARP2 and PARP3.

Beck C, Robert I, Reina-San-Martin B, Schreiber V, Dantzer F

Exp Cell Res. 2014 Nov 15;329(1):18-25

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.

Cerutti R, Pirinen E, Lamperti C, Marchet S, Sauve AA, Li W, Leoni V, Schon EA, Dantzer F, Auwerx J, Viscomi C, Zeviani M

Cell Metab. 2014 Jun 3;19(6):1042-9

Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions.

De Vos M, El Ramy R, Quenet D, Wolf P, Spada F, Magroun N, Babbio F, Schreiber V, Leonhardt H, Bonapace IM, Dantzer F

J Biol Chem. 2014 Jun 6;289(23):16223-38

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.

Illuzzi G, Fouquerel E, Ame JC, Noll A, Rehmet K, Nasheuer HP, Dantzer F, Schreiber V

Nucleic Acids Res. 2014;42(12):7776-92

Functional aspects of PARylation in induced and programmed DNA repair processes: preserving genome integrity and modulating physiological events.

Robert I, Karicheva O, Reina San Martin B, Schreiber V, Dantzer F

Mol Aspects Med. 2013 Dec;34(6):1138-52

The expanding role of PARPs in the establishment and maintenance of heterochromatin.

Dantzer F, Santoro R

FEBS J. 2013 Aug;280(15):3508-18

Parp-2 is required to maintain hematopoiesis following sublethal gamma-irradiation in mice.

Farres J, Martin-Caballero J, Martinez C, Lozano JJ, Llacuna L, Ampurdanes C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yelamos J

Blood. 2013 Jul 4;122(1):44-54

Cell death associated with abnormal mitosis observed by confocal imaging in live cancer cells.

Castiel A, Visochek L, Mittelman L, Zilberstein Y, Dantzer F, Izraeli S, Cohen-Armon M

J Vis Exp. 2013 Aug 21;(78):e50568

The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.

Legrand AJ, Choul-Li S, Spriet C, Idziorek T, Vicogne D, Drobecq H, Dantzer F, Villeret V, Aumercier M

PLoS One. 2013;8(2):e55883

New readers and interpretations of poly(ADP-ribosyl)ation.

Kalisch T, Ame JC, Dantzer F, Schreiber V

Trends Biochem Sci. 2012 Sep;37(9):381-90

The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art.

De Vos M, Schreiber V, Dantzer F

Biochem Pharmacol. 2012 Jul 15;84(2):137-46

Decreasing Poly(ADP-Ribose) Polymerase Activity Restores DeltaF508 CFTR Trafficking.

Anjos SM, Robert R, Waller D, Zhang DL, Balghi H, Sampson HM, Ciciriello F, Lesimple P, Carlile GW, Goepp J, Liao J, Ferraro P, Phillipe R, Dantzer F, Hanrahan JW, Thomas DY

Front Pharmacol. 2012;3:165

Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.

Rodriguez MI, Gonzalez-Flores A, Dantzer F, Collard J, de Herreros AG, Oliver FJ

Oncogene. 2011 Oct 20;30(42):4365-72

[PARP inhibitors: significant progress in cancer therapy].

Dantzer F, Noel G, Schreiber V

Bull Cancer. 2011 Mar 1;98(3):277-90.

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.

Castiel A, Visochek L, Mittelman L, Dantzer F, Izraeli S, Cohen-Armon M

BMC Cancer. 2011 Sep 26;11:412.

Phenotypic characterization of Parp-1 and Parp-2 deficient mice and cells.

Boehler C, Gauthier L, Yelamos J, Noll A, Schreiber V, Dantzer F

Methods Mol Biol. 2011;780:313-36.

Purification of recombinant poly(ADP-ribose) polymerases.

Ame JC, Kalisch T, Dantzer F, Schreiber V

Methods Mol Biol. 2011;780:135-52.

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice.

Nicolas L, Martinez C, Baro C, Rodriguez M, Baroja-Mazo A, Sole F, Flores JM, Ampurdanes C, Dantzer F, Martin-Caballero J, Aparicio P, Yelamos J

Oncogene. 2010 May 13;29(19):2877-83

Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.

El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F

Cell Mol Life Sci. 2009 Oct;66(19):3219-34

Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.

Quenet D, Mark M, Govin J, van Dorsselear A, Schreiber V, Khochbin S, Dantzer F

Exp Cell Res. 2009 Oct 1;315(16):2824-34

Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks.

Kotoglou P, Kalaitzakis A, Vezyraki P, Tzavaras T, Michalis LK, Dantzer F, Jung JU, Angelidis C

Cell Stress Chaperones. 2009 Jul;14(4):391-406

Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.

Ambrose HE, Willimott S, Beswick RW, Dantzer F, de Murcia JM, Yelamos J, Wagner SD

Immunology. 2009 Jun;127(2):178-86

Radiation-induced mitotic catastrophe in PARG-deficient cells

Ame JC, Fouquerel E, Gauthier LR, Biard D, Boussin FD, Dantzer F, de Murcia G, Schreiber V

J Cell Sci. 2009 Jun 15;122(Pt 12):1990-2002

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.

Robert I, Dantzer F, Reina-San-Martin B

J Exp Med. 2009 May 11;206(5):1047-56

A selective eradication of human nonhereditary breast cancer cells by phenanthridine-derived polyADP-ribose polymerase inhibitors.

Inbar-Rozensal D, Castiel A, Visochek L, Castel D, Dantzer F, Izraeli S, Cohen-Armon M

Breast Cancer Res. 2009;11(6):R78

Detection of the nuclear poly(ADP-ribose)-metabolizing enzymes and activities in response to DNA damage.

Ame JC, Hakme A, Quenet D, Fouquerel E, Dantzer F, Schreiber V

Methods Mol Biol. 2009;464:267-83.

The role of poly(ADP-ribosyl)ation in epigenetic events.

Quenet D, El Ramy R, Schreiber V, Dantzer F

Int J Biochem Cell Biol. 2009 Jan;41(1):60-5

The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.

Hakme A, Wong HK, Dantzer F, Schreiber V

EMBO Rep. 2008 Nov;9(11):1094-100

The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha.

Quenet D, Gasser V, Fouillen L, Cammas F, Sanglier-Cianferani S, Losson R, Dantzer F

FASEB J. 2008 Nov;22(11):3853-65

Dynamic relocalization of hOGG1 during the cell cycle is disrupted in cells harbouring the hOGG1-Cys326 polymorphic variant.

Luna L, Rolseth V, Hildrestrand GA, Otterlei M, Dantzer F, Bjoras M, Seeberg E

Nucleic Acids Res. 2005 Mar 30;33(6):1813-24. Print 2005.

Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

Dantzer F, Giraud-Panis MJ, Jaco I, Ame JC, Schultz I, Blasco M, Koering CE, Gilson E, Menissier-de Murcia J, de Murcia G, Schreiber V

Mol Cell Biol. 2004 Feb;24(4):1595-607.

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