Meedt E, Weber D, Bonifacius A, Eiz-Vesper B, Maecker-Kolhoff B, Delecluse S, Delecluse HJ, Lorenz M, Schwarz K, Meedt ST, Braess J, Herr W, Holler E, Edinger M, Wolff D

Clin Infect Dis. 2023 03 8;:

Latent Membrane Protein 1 and macrophage-derived TNFα synergistically activate and mobilize invadopodia to drive invasion of nasopharyngeal carcinoma.

Tang WC, Tsao SW, Jones GE, Liu X, Tsai MH, Delecluse HJ, Dai W, You C, Zhang J, Huang SCM, Leung MM, Liu T, Ching YP, Chen H, Lo KW, Li X, Tsang CM

J Pathol. 2022 11 24;:

BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1.

Delage L, Lambert M, Bardel E, Kundlacz C, Chartoire D, Conchon A, Peugnet AL, Gorka L, Auberger P, Jacquel A, Soussain C, Destaing O, Delecluse HJ, Delecluse S, Merabet S, Traverse-Glehen A, Salles GA, Bachy E, Billaud M, Ghesquieres H, Genestier L, Rouault JP, Sujobert P

Blood. 2022 11 14;:

The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth.

Li Z, Baccianti F, Delecluse S, Tsai MH, Shumilov A, Cheng X, Ma S, Hoffmann I, Poirey R, Delecluse HJ

Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):

Metagenomic analysis of primary colorectal carcinomas and their metastases identifies potential microbial risk factors.

Marongiu L, Landry JJM, Rausch T, Abba ML, Delecluse S, Delecluse HJ, Allgayer H

Mol Oncol. 2021 Jul 30;:

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy.

Lechner M, Schartinger VH, Steele CD, Nei WL, Ooft ML, Schreiber LM, Pipinikas CP, Chung GT, Chan YY, Wu F, To KF, Tsang CM, Pearce W, Morelli D, Philpott M, Masterson L, Nibhani R, Wells G, Bell CG, Koller J, Delecluse S, Yip YL, Liu J, Forde CT, Forster MD, Jay A, Dudás J, Krapp A, Wan S, Uprimny C, Sprung S, Haybaeck J, Fenton TR, Chester K, Thirlwell C, Royle G, Marafioti T, Gupta R, Indrasari SR, Herdini C, Slim MAM, Indrawati I, Sutton L, Fles R, Tan B, Yeong J, Jain A, Han S, Wang H, Loke KSH, He W, Xu R, Jin H, Cheng Z, Howard D, Hwang PH, Le QT, Tay JK, West RB, Tsao SW, Meyer T, Riechelmann H, Oppermann U, Delecluse HJ, Willems SM, Chua MLK, Busson P, Lo KW, Wollmann G, Pillay N, Vanhaesebroeck B, Lund VJ

Nat Commun. 2021 01 5;12(1):117

Rapid identification and characterization of infected cells in blood during chronic active Epstein-Barr virus infection.

Fournier B, Boutboul D, Bruneau J, Miot C, Boulanger C, Malphettes M, Pellier I, Dunogué B, Terrier B, Suarez F, Blanche S, Castelle M, Winter S, Delecluse HJ, Molina T, Picard C, Ehl S, Moshous D, Galicier L, Barlogis V, Fischer A, Neven B, Latour S

J. Exp. Med.. 2020 Nov 2;217(11):

Identification and cloning of a new western Epstein-Barr virus strain that replicates efficiently in primary B cells.

Delecluse S, Poirey R, Zeier M, Schnitzler P, Behrends U, Tsai MH, Delecluse HJ

J. Virol.. 2020 Feb 26;:

PD-1 Blockade Aggravates Epstein-Barr Virus Post-Transplant Lymphoproliferative Disorder in Humanized Mice Resulting in Central Nervous System Involvement and CD4 T Cell Dysregulations.

Volk V, Theobald SJ, Danisch S, Khailaie S, Kalbarczyk M, Schneider A, Bialek-Waldmann J, Krönke N, Deng Y, Eiz-Vesper B, Dragon AC, von Kaisenberg C, Lienenklaus S, Bleich A, Keck J, Meyer-Hermann M, Klawonn F, Hammerschmidt W, Delecluse HJ, Münz C, Feuerhake F, Stripecke R

Front Oncol. 2020 ;10:614876

Epstein-Barr virus ncRNA from a nasopharyngeal carcinoma induces an inflammatory response that promotes virus production.

Li Z, Tsai MH, Shumilov A, Baccianti F, Tsao SW, Poirey R, Delecluse HJ

Nat Microbiol. 2019 Sep 9;:

A single phosphoacceptor residue in BGLF3 is essential for transcription of Epstein-Barr virus late genes.

Li J, Walsh A, Lam TT, Delecluse HJ, El-Guindy A

PLoS Pathog.. 2019 Aug;15(8):e1007980

Progress in EBV Vaccines.

van Zyl DG, Mautner J, Delecluse HJ

Front Oncol. 2019 ;9:104

Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs.

Delecluse S, Yu J, Bernhardt K, Haar J, Poirey R, Tsai MH, Kiblawi R, Kopp-Schneider A, Schnitzler P, Zeier M, Dreger P, Wuchter P, Bulut OC, Behrends U, Delecluse HJ

PLoS ONE. 2019 ;14(9):e0222847

The Epstein-Barr virus induces the expression of the LPAM-1 integrin in B-cells and .

Delecluse S, Tsai MH, Shumilov A, Bencun M, Arrow S, Beshirova A, Cottignies-Calamarte A, Lasitschka F, Bulut OC, Münz C, Zeier M, Behrends U, Delecluse HJ

J. Virol.. 2018 Dec 12;:

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice.

van Zyl DG, Tsai MH, Shumilov A, Schneidt V, Poirey R, Schlehe B, Fluhr H, Mautner J, Delecluse HJ

PLoS Pathog.. 2018 Dec 6;14(12):e1007464

Antigen-armed antibodies against B-cell malignancies.

Ilecka M, van Zyl DG, Delecluse HJ

Oncotarget. 2018 Nov 2;9(86):35601-35602

Antibodies conjugated with viral antigens elicit a cytotoxic T cell response against primary CLL ex vivo.

Schneidt V, Ilecka M, Dreger P, van Zyl DG, Fink S, Mautner J, Delecluse HJ

Leukemia. 2018 Jun 20;:

Translational profiling of B cells infected with the Epstein-Barr virus reveals 5' leader ribosome recruitment through upstream open reading frames.

Bencun M, Klinke O, Hotz-Wagenblatt A, Klaus S, Tsai MH, Poirey R, Delecluse HJ

Nucleic Acids Res.. 2018 Apr 6;46(6):2802-2819

Epstein-Barr virus strain heterogeneity impairs human T-cell immunity.

Cirac A, Stützle S, Dieckmeyer M, Adhikary D, Moosmann A, Körber N, Bauer T, Witter K, Delecluse HJ, Behrends U, Mautner J

Cancer Immunol. Immunother.. 2018 Apr;67(4):663-674

Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.

Gupta S, Ylä-Anttila P, Callegari S, Tsai MH, Delecluse HJ, Masucci MG

PLoS Pathog.. 2018 Jan;14(1):e1006852

Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression.

McHugh D, Caduff N, Barros MHM, Rämer PC, Raykova A, Murer A, Landtwing V, Quast I, Styles CT, Spohn M, Fowotade A, Delecluse HJ, Papoudou-Bai A, Lee YM, Kim JM, Middeldorp J, Schulz TF, Cesarman E, Zbinden A, Capaul R, White RE, Allday MJ, Niedobitek G, Blackbourn DJ, Grundhoff A, Münz C

Cell Host Microbe. 2017 Jul;22(1):61-73.e7

Leflunomide/teriflunomide inhibit Epstein-barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.

Bilger A, Plowshay J, Ma S, Nawandar D, Barlow EA, Romero-Masters JC, Bristol JA, Li Z, Tsai MH, Delecluse HJ, Kenney SC

Oncotarget. 2017 May;:

Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential.

Ma SD, Tsai MH, Romero-Masters JC, Ranheim EA, Huebner SM, Bristol JA, Delecluse HJ, Kenney SC

J. Virol.. 2017 Apr;91(7):

Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.

Shumilov A, Tsai MH, Schlosser YT, Kratz AS, Bernhardt K, Fink S, Mizani T, Lin X, Jauch A, Mautner J, Kopp-Schneider A, Feederle R, Hoffmann I, Delecluse HJ

Nat Commun. 2017 Feb;8:14257

The biological properties of different Epstein-Barr virus strains explain their association with various types of cancers.

Tsai MH, Lin X, Shumilov A, Bernhardt K, Feederle R, Poirey R, Kopp-Schneider A, Pereira B, Almeida R, Delecluse HJ

Oncotarget. 2017 Feb;8(6):10238-10254

Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency.

Dheekollu J, Malecka K, Wiedmer A, Delecluse HJ, Chiang AK, Altieri DC, Messick TE, Lieberman PM

Oncotarget. 2017 Jan;8(5):7248-7264

The Epstein-Barr virus DNA load in the peripheral blood of transplant recipients does not accurately reflect the burden of infected cells.

Fink S, Tsai MH, Schnitzler P, Zeier M, Dreger P, Wuchter P, Bulut OC, Behrends U, Delecluse HJ

Transpl. Int.. 2017 Jan;30(1):57-67

Fbxo28 promotes mitotic progression and regulates topoisomerase IIα-dependent DNA decatenation.

Kratz AS, Richter KT, Schlosser YT, Schmitt M, Shumilov A, Delecluse HJ, Hoffmann I

Cell Cycle. 2016 Dec;15(24):3419-3431

The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.

McKenzie J, Lopez-Giraldez F, Delecluse HJ, Walsh A, El-Guindy A

PLoS Pathog.. 2016 Nov;12(11):e1006008

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

Ma SD, Xu X, Jones R, Delecluse HJ, Zumwalde NA, Sharma A, Gumperz JE, Kenney SC

PLoS Pathog.. 2016 May;12(5):e1005642

The expression of a viral microRNA is regulated by clustering to allow optimal B cell transformation.

Haar J, Contrant M, Bernhardt K, Feederle R, Diederichs S, Pfeffer S, Delecluse HJ

Nucleic Acids Res.. 2016 Feb;44(3):1326-41

A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog.

Bernhardt K, Haar J, Tsai MH, Poirey R, Feederle R, Delecluse HJ

PLoS Pathog.. 2016 Jan;12(1):e1005405

Modulation of MicroRNA Cluster miR-183-96-182 Expression by Epstein-Barr Virus Latent Membrane Protein 1.

Oussaief L, Fendri A, Chane-Woon-Ming B, Poirey R, Delecluse HJ, Joab I, Pfeffer S

J Virol. 2015 Dec 1;89(23):12178-88

The Epstein-Barr Virus BART miRNA Cluster of the M81 Strain Modulates Multiple Functions in Primary B Cells.

Lin X, Tsai MH, Shumilov A, Poirey R, Bannert H, Middeldorp JM, Feederle R, Delecluse HJ

PLoS Pathog.. 2015 Dec;11(12):e1005344

Epstein-Barr Virus BZLF1-Mediated Down-regulation of Pro-inflammatory Factors is Essential for Optimal Lytic Viral Replication.

Li Y, Long X, Huang L, Yang M, Yuan Y, Wang Y, Delecluse HJ, Kuang E

J Virol. 2015 Nov 4. pii: JVI.01921-15.

Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells.

Yu X, Ilecka M, Bartlett EJ, Schneidt V, Bhat R, Mautner J, Feederle R, Delecluse HJ

Blood. 2015 Mar;125(10):1601-10

Epstein-Barr Virus: From the Detection of Sequence Polymorphisms to the Recognition of Viral Types.

Feederle R, Klinke O, Kutikhin A, Poirey R, Tsai MH, Delecluse HJ

Curr Top Microbiol Immunol. 2015;390:119-48

KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

Klinke OK, Mizani T, Baldwin G, Bancel B, Devouassoux-Shisheboran M, Scoazec JY, Bringuier PP, Feederle R, Jauch A, Hinderhofer K, Taniere P, Delecluse HJ

PLoS One. 2015 Jun 23;10(6):e0130149

Telomerase Activity Impacts on Epstein-Barr Virus Infection of AGS Cells.

Rac J, Haas F, Schumacher A, Middeldorp JM, Delecluse HJ, Speck RF, Bernasconi M, Nadal D

PLoS One. 2015 Apr 9;10(4):e0123645

A locus encompassing the Epstein-Barr virus bglf4 kinase regulates expression of genes encoding viral structural proteins.

El-Guindy A, Lopez-Giraldez F, Delecluse HJ, McKenzie J, Miller G

PLoS Pathog. 2014 Aug 28;10(8):e1004307

Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.

Antsiferova O, Muller A, Ramer PC, Chijioke O, Chatterjee B, Raykova A, Planas R, Sospedra M, Shumilov A, Tsai MH, Delecluse HJ, Munz C

PLoS Pathog. 2014 Aug 28;10(8):e1004333

Genetics of Epstein-Barr virus microRNAs.

Klinke O, Feederle R, Delecluse HJ

Semin Cancer Biol. 2014 Jun;26:52-9

Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection.

Chijioke O, Muller A, Feederle R, Barros MH, Krieg C, Emmel V, Marcenaro E, Leung CS, Antsiferova O, Landtwing V, Bossart W, Moretta A, Hassan R, Boyman O, Niedobitek G, Delecluse HJ, Capaul R, Munz C

Cell Rep. 2013 Dec 26;5(6):1489-98

Spontaneous lytic replication and epitheliotropism define an Epstein-Barr virus strain found in carcinomas.

Tsai MH, Raykova A, Klinke O, Bernhardt K, Gartner K, Leung CS, Geletneky K, Sertel S, Munz C, Feederle R, Delecluse HJ

Cell Rep. 2013 Oct 31;5(2):458-70

A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo.

Wahl A, Linnstaedt SD, Esoda C, Krisko JF, Martinez-Torres F, Delecluse HJ, Cullen BR, Garcia JV

J Virol. 2013 May;87(10):5437-46

An Epstein-Barr virus mutant produces immunogenic defective particles devoid of viral DNA.

Pavlova S, Feederle R, Gartner K, Fuchs W, Granzow H, Delecluse HJ

J Virol. 2013 Feb;87(4):2011-22

Epidemiology and morbidity of Epstein-Barr virus infection in pediatric renal transplant recipients: a multicenter, prospective study.

Hocker B, Fickenscher H, Delecluse HJ, Bohm S, Kusters U, Schnitzler P, Pohl M, John U, Kemper MJ, Fehrenbach H, Wigger M, Holder M, Schroder M, Billing H, Fichtner A, Feneberg R, Sander A, Kopf-Shakib S, Susal C, Tonshoff B

Clin Infect Dis. 2013 Jan;56(1):84-92

Essential role of Rta in lytic DNA replication of Epstein-Barr virus.

El-Guindy A, Ghiassi-Nejad M, Golden S, Delecluse HJ, Miller G

J Virol. 2013 Jan;87(1):208-23

The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion.

Hernando H, Shannon-Lowe C, Islam AB, Al-Shahrour F, Rodriguez-Ubreva J, Rodriguez-Cortez VC, Javierre BM, Mangas C, Fernandez AF, Parra M, Delecluse HJ, Esteller M, Lopez-Granados E, Fraga MF, Lopez-Bigas N, Ballestar E

Genome Biol. 2013 Jan 15;14(1):R3

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